Evaluation of Some Micronutrients among Sickle Cell Disease Patients in Benin City, Edo State, Nigeria.
Sickle cell disease (SCD) is an inherited disorder of haemoglobin caused by a single nucleotide substitution of thymidine for adenine (GAG-GTG) of the β-chain that results in the amino acid valine instead of glutamic acid. This congenital haemoglobin mutation alters this balance and creates a pro-ox...
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Hammer Head Production Limited
2016-07-01
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| Series: | Sokoto Journal of Medical Laboratory Science |
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| Online Access: | https://sokjmls.com.ng/index.php/SJMLS/article/view/386 |
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| author | Digban, A.K., Okogun, G.R.A., Adu, M.E.* and Jemikalajah, J.D. |
| author_facet | Digban, A.K., Okogun, G.R.A., Adu, M.E.* and Jemikalajah, J.D. |
| author_sort | Digban, A.K., Okogun, G.R.A., Adu, M.E.* and Jemikalajah, J.D. |
| collection | DOAJ |
| description | Sickle cell disease (SCD) is an inherited disorder of haemoglobin caused by a single nucleotide substitution of thymidine for adenine (GAG-GTG) of the β-chain that results in the amino acid valine instead of glutamic acid. This congenital haemoglobin mutation alters this balance and creates a pro-oxidant and micronutrient reactive milieu. This study investigated some micronutrients status of sickle cell patients. A total of one hundred (100) participants were recruited for this study which consists of fifty (50) sickle cell subjects and fifty (50) apparently healthy age -matched individuals were monitored as control. Blood samples were collected by venepuncture and some micronutrients (Iron, Zinc, Manganese, cobalt, Calcium and Magnesium) were analyzed using Atomic Absorption Spectrophotometer. All parameters were significantly decreased in sickle cell patients when compared with apparently controls (p<0.05). Considering the results obtained in this study, it could be inferred that sickle cell subjects are predisposed to nutritional deficiencies. We therefore advocate routine assessment of micronutrients in sickle cell patients. It may be necessary to routinely provide nutritional supplements for sickle cell disease patients in Nigeria. |
| format | Article |
| id | doaj-art-d4d941c3a5bd48e9895a54cb7057a0c2 |
| institution | OA Journals |
| issn | 2536-7153 |
| language | English |
| publishDate | 2016-07-01 |
| publisher | Hammer Head Production Limited |
| record_format | Article |
| series | Sokoto Journal of Medical Laboratory Science |
| spelling | doaj-art-d4d941c3a5bd48e9895a54cb7057a0c22025-08-20T01:49:11ZengHammer Head Production LimitedSokoto Journal of Medical Laboratory Science2536-71532016-07-0111386Evaluation of Some Micronutrients among Sickle Cell Disease Patients in Benin City, Edo State, Nigeria.Digban, A.K., Okogun, G.R.A., Adu, M.E.* and Jemikalajah, J.D.Sickle cell disease (SCD) is an inherited disorder of haemoglobin caused by a single nucleotide substitution of thymidine for adenine (GAG-GTG) of the β-chain that results in the amino acid valine instead of glutamic acid. This congenital haemoglobin mutation alters this balance and creates a pro-oxidant and micronutrient reactive milieu. This study investigated some micronutrients status of sickle cell patients. A total of one hundred (100) participants were recruited for this study which consists of fifty (50) sickle cell subjects and fifty (50) apparently healthy age -matched individuals were monitored as control. Blood samples were collected by venepuncture and some micronutrients (Iron, Zinc, Manganese, cobalt, Calcium and Magnesium) were analyzed using Atomic Absorption Spectrophotometer. All parameters were significantly decreased in sickle cell patients when compared with apparently controls (p<0.05). Considering the results obtained in this study, it could be inferred that sickle cell subjects are predisposed to nutritional deficiencies. We therefore advocate routine assessment of micronutrients in sickle cell patients. It may be necessary to routinely provide nutritional supplements for sickle cell disease patients in Nigeria.https://sokjmls.com.ng/index.php/SJMLS/article/view/386micronutrients, sickle cell disease, benin city, edo state, nigeria |
| spellingShingle | Digban, A.K., Okogun, G.R.A., Adu, M.E.* and Jemikalajah, J.D. Evaluation of Some Micronutrients among Sickle Cell Disease Patients in Benin City, Edo State, Nigeria. Sokoto Journal of Medical Laboratory Science micronutrients, sickle cell disease, benin city, edo state, nigeria |
| title | Evaluation of Some Micronutrients among Sickle Cell Disease Patients in Benin City, Edo State, Nigeria. |
| title_full | Evaluation of Some Micronutrients among Sickle Cell Disease Patients in Benin City, Edo State, Nigeria. |
| title_fullStr | Evaluation of Some Micronutrients among Sickle Cell Disease Patients in Benin City, Edo State, Nigeria. |
| title_full_unstemmed | Evaluation of Some Micronutrients among Sickle Cell Disease Patients in Benin City, Edo State, Nigeria. |
| title_short | Evaluation of Some Micronutrients among Sickle Cell Disease Patients in Benin City, Edo State, Nigeria. |
| title_sort | evaluation of some micronutrients among sickle cell disease patients in benin city edo state nigeria |
| topic | micronutrients, sickle cell disease, benin city, edo state, nigeria |
| url | https://sokjmls.com.ng/index.php/SJMLS/article/view/386 |
| work_keys_str_mv | AT digbanakokogungraadumeandjemikalajahjd evaluationofsomemicronutrientsamongsicklecelldiseasepatientsinbenincityedostatenigeria |