Role of E-cadherin and β-catenin in head and neck squamous cell carcinoma
Aim of the study: to present and summarize current data on the prognostic value of E-cadherin and β-catenin markers for head and neck squamous cell carcinoma, as well as to substantiate the potential benefit from implementing research results into clinical practice within the framework of a personal...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2024-01-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/2843 |
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| author | A. A. Petrova S. I. Samoylova L. V. Magomedkerimova S. A. Parts I. V. Reshetov |
| author_facet | A. A. Petrova S. I. Samoylova L. V. Magomedkerimova S. A. Parts I. V. Reshetov |
| author_sort | A. A. Petrova |
| collection | DOAJ |
| description | Aim of the study: to present and summarize current data on the prognostic value of E-cadherin and β-catenin markers for head and neck squamous cell carcinoma, as well as to substantiate the potential benefit from implementing research results into clinical practice within the framework of a personalized approach to the treatment of head and neck squamous cell carcinoma.Material and Methods. We performed a literature search and review in Pubmed, Scopus, Google Scholar and RSCI databases regarding the association of the level of E-cadherin and β-catenin markers with disease prognosis, aggressiveness of tumor behavior and response to treatment.Results. Detailed information on the functions and mechanisms of E-cadherin and β-catenin proteins were presented and pathogenetic pathways involved in epithelial-mesenchymal transition were described. The results of studies on the association of β-catenin and E-cadherin expression levels with the prognosis of head and neck squamous cell carcinoma are collected and summarized. High expression levels of β-catenin and E-cadherin are associated with lymph node metastasis, poor prognosis and poor response to treatment.Conclusion. The expression levels of β-catenin and E-cadherin correlate with tumor invasion and lymph node metastasis, thus suggesting that β-catenin and E-cadherin can be used as potential markers of prognosis and treatment response in patients with head and neck squamous cell carcinoma. Further studies are needed to evaluate the co-expression of E-cadherin, β-catenin and other squamous cell carcinoma-associated markers, their impact on prognosis and treatment response, as well as their prognostic value. |
| format | Article |
| id | doaj-art-d4d7874cfcb842baa66dc6d558f8aba3 |
| institution | Kabale University |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2024-01-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-d4d7874cfcb842baa66dc6d558f8aba32025-08-20T03:43:40ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682024-01-0122613013710.21294/1814-4861-2023-22-6-130-1371191Role of E-cadherin and β-catenin in head and neck squamous cell carcinomaA. A. Petrova0S. I. Samoylova1L. V. Magomedkerimova2S. A. Parts3I. V. Reshetov4I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the RussiaI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the RussiaI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the RussiaMoscow Clinical Oncology Hospital No. 1I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the RussiaAim of the study: to present and summarize current data on the prognostic value of E-cadherin and β-catenin markers for head and neck squamous cell carcinoma, as well as to substantiate the potential benefit from implementing research results into clinical practice within the framework of a personalized approach to the treatment of head and neck squamous cell carcinoma.Material and Methods. We performed a literature search and review in Pubmed, Scopus, Google Scholar and RSCI databases regarding the association of the level of E-cadherin and β-catenin markers with disease prognosis, aggressiveness of tumor behavior and response to treatment.Results. Detailed information on the functions and mechanisms of E-cadherin and β-catenin proteins were presented and pathogenetic pathways involved in epithelial-mesenchymal transition were described. The results of studies on the association of β-catenin and E-cadherin expression levels with the prognosis of head and neck squamous cell carcinoma are collected and summarized. High expression levels of β-catenin and E-cadherin are associated with lymph node metastasis, poor prognosis and poor response to treatment.Conclusion. The expression levels of β-catenin and E-cadherin correlate with tumor invasion and lymph node metastasis, thus suggesting that β-catenin and E-cadherin can be used as potential markers of prognosis and treatment response in patients with head and neck squamous cell carcinoma. Further studies are needed to evaluate the co-expression of E-cadherin, β-catenin and other squamous cell carcinoma-associated markers, their impact on prognosis and treatment response, as well as their prognostic value.https://www.siboncoj.ru/jour/article/view/2843e-cadherinβ-cateninsquamous cell carcinomacarcinomaepithelial-mesenchymal transitionprognostic factorhead and neck organs |
| spellingShingle | A. A. Petrova S. I. Samoylova L. V. Magomedkerimova S. A. Parts I. V. Reshetov Role of E-cadherin and β-catenin in head and neck squamous cell carcinoma Сибирский онкологический журнал e-cadherin β-catenin squamous cell carcinoma carcinoma epithelial-mesenchymal transition prognostic factor head and neck organs |
| title | Role of E-cadherin and β-catenin in head and neck squamous cell carcinoma |
| title_full | Role of E-cadherin and β-catenin in head and neck squamous cell carcinoma |
| title_fullStr | Role of E-cadherin and β-catenin in head and neck squamous cell carcinoma |
| title_full_unstemmed | Role of E-cadherin and β-catenin in head and neck squamous cell carcinoma |
| title_short | Role of E-cadherin and β-catenin in head and neck squamous cell carcinoma |
| title_sort | role of e cadherin and β catenin in head and neck squamous cell carcinoma |
| topic | e-cadherin β-catenin squamous cell carcinoma carcinoma epithelial-mesenchymal transition prognostic factor head and neck organs |
| url | https://www.siboncoj.ru/jour/article/view/2843 |
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