CD34 Angiogenesis Marker in Oral Squamous Cell Carcinoma: An Immunohistochemical Study
Background: Angiogenesis is recognized as a predominant factor for tumor growth and metastasis. Use of biomarkers to target tumor holds a promising treatment strategy and to assess prognosis. Objectives: To assess angiogenic activity by analyzing CD34 microvascular density (MVD) count in different h...
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Contemporary Clinical Dentistry |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ccd.ccd_545_24 |
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| _version_ | 1850038337574797312 |
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| author | Vijayalaxmi Sunil S Mishra N. C. Sangamesh |
| author_facet | Vijayalaxmi Sunil S Mishra N. C. Sangamesh |
| author_sort | Vijayalaxmi |
| collection | DOAJ |
| description | Background:
Angiogenesis is recognized as a predominant factor for tumor growth and metastasis. Use of biomarkers to target tumor holds a promising treatment strategy and to assess prognosis.
Objectives:
To assess angiogenic activity by analyzing CD34 microvascular density (MVD) count in different histologic grades of oral squamous cell carcinoma (OSCC).
Materials and Methods:
Sixty archival samples are categorized in four groups. Immunohistochemical method with anti-CD34 was used for analyzing MVD.
Results:
The mean count of MVD is higher in OSCC than in normal mucosa and also significant among different histologic grades. Highly significant correlation is observed among different groups of OSCC samples.
Conclusion:
CD34 shows a promising result in OSCC. |
| format | Article |
| id | doaj-art-d4d4b900cfcf4d4b87f72bce6e7df758 |
| institution | DOAJ |
| issn | 0976-237X 0976-2361 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Contemporary Clinical Dentistry |
| spelling | doaj-art-d4d4b900cfcf4d4b87f72bce6e7df7582025-08-20T02:56:37ZengWolters Kluwer Medknow PublicationsContemporary Clinical Dentistry0976-237X0976-23612025-04-0116212412710.4103/ccd.ccd_545_24CD34 Angiogenesis Marker in Oral Squamous Cell Carcinoma: An Immunohistochemical StudyVijayalaxmiSunil S MishraN. C. SangameshBackground: Angiogenesis is recognized as a predominant factor for tumor growth and metastasis. Use of biomarkers to target tumor holds a promising treatment strategy and to assess prognosis. Objectives: To assess angiogenic activity by analyzing CD34 microvascular density (MVD) count in different histologic grades of oral squamous cell carcinoma (OSCC). Materials and Methods: Sixty archival samples are categorized in four groups. Immunohistochemical method with anti-CD34 was used for analyzing MVD. Results: The mean count of MVD is higher in OSCC than in normal mucosa and also significant among different histologic grades. Highly significant correlation is observed among different groups of OSCC samples. Conclusion: CD34 shows a promising result in OSCC.https://journals.lww.com/10.4103/ccd.ccd_545_24angiogenesiscd34microvessel densityoral squamous cell carcinomatumor |
| spellingShingle | Vijayalaxmi Sunil S Mishra N. C. Sangamesh CD34 Angiogenesis Marker in Oral Squamous Cell Carcinoma: An Immunohistochemical Study Contemporary Clinical Dentistry angiogenesis cd34 microvessel density oral squamous cell carcinoma tumor |
| title | CD34 Angiogenesis Marker in Oral Squamous Cell Carcinoma: An Immunohistochemical Study |
| title_full | CD34 Angiogenesis Marker in Oral Squamous Cell Carcinoma: An Immunohistochemical Study |
| title_fullStr | CD34 Angiogenesis Marker in Oral Squamous Cell Carcinoma: An Immunohistochemical Study |
| title_full_unstemmed | CD34 Angiogenesis Marker in Oral Squamous Cell Carcinoma: An Immunohistochemical Study |
| title_short | CD34 Angiogenesis Marker in Oral Squamous Cell Carcinoma: An Immunohistochemical Study |
| title_sort | cd34 angiogenesis marker in oral squamous cell carcinoma an immunohistochemical study |
| topic | angiogenesis cd34 microvessel density oral squamous cell carcinoma tumor |
| url | https://journals.lww.com/10.4103/ccd.ccd_545_24 |
| work_keys_str_mv | AT vijayalaxmi cd34angiogenesismarkerinoralsquamouscellcarcinomaanimmunohistochemicalstudy AT sunilsmishra cd34angiogenesismarkerinoralsquamouscellcarcinomaanimmunohistochemicalstudy AT ncsangamesh cd34angiogenesismarkerinoralsquamouscellcarcinomaanimmunohistochemicalstudy |