UPLC-MS/MS method for simultaneous determination of pyrantel, praziquantel, febantel, fenbendazole and oxfendazole in dog plasma and its application to a bioequivalence study

UPLC-MS/MS method for simultaneous determination of pyrantel, praziquantel, febantel, fenbendazole and oxfendazole in dog plasma and its application to a bioequivalence study

A rapid, sensitive and reliable ultra–performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) was developed and validated for the simultaneous quantitation of pyrantel (PYR), praziquantel (PRA), febantel (FBT) and its active metabolites, fenbendazole (FEN) and oxfendazole (OXF) in do...

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Bibliographic Details
Main Authors: Fengyichi Zhang, Fanxi Guo, Xinyu Zhao, Chongyang Li, Junli Wang, Mengyun Wang, Ruixia Ma, Baochang Chen, Qiangqiang Miao, Yimeng Wang, Zihan Wang, Di Cao, Zugong Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
pyrantel
praziquantel
febantel
fenbendazole
oxfendazole
UPLC-MS/MS
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1544215/full
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