Ovarian Brenner Tumors Revisited: Do We Have Space for Malignant Tumorsvand Methanol
We present a case of a 75-year-old female who underwent a total abdominal hysterectomy with bilateral salpingooophorectomy for an ovarian tumor. Hematoxylin-eosin- stained slides from tumor specimen revealed 1) focci of benign Brenner tumor; 2) mucinous cysts and 3) intracystic papillary projections...
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| Language: | English |
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Medical University - Pleven
2016-09-01
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| Series: | Journal of Biomedical & Clinical Research |
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| Online Access: | https://jbcr.arphahub.com/article/34422/download/pdf/ |
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| author | Vesela Ivanova Milen Karaivanov Tihomir Dikov |
| author_facet | Vesela Ivanova Milen Karaivanov Tihomir Dikov |
| author_sort | Vesela Ivanova |
| collection | DOAJ |
| description | We present a case of a 75-year-old female who underwent a total abdominal hysterectomy with bilateral salpingooophorectomy for an ovarian tumor. Hematoxylin-eosin- stained slides from tumor specimen revealed 1) focci of benign Brenner tumor; 2) mucinous cysts and 3) intracystic papillary projections resembling low-grade papillary transitional cell carcinoma (Grade 1-2) with squamous differentiation and comedo-type necrosis; 4) focal areas resembling noninvasive papillary transitional cell carcinoma Grade 3. Immunohistochemical investigation with a panel of antibodies (p63, p53, Ki-67, Wilms Tumor 1 - WT1, pi 6) was initiated. Areas resembling urothelial carcinoma showed diffuse nuclear positive reaction for p63 and wild-type expression of p53. Ki-67-nuclear positivity varied from less than 5% up to 30% in areas resembling high-grade urothelial carcinoma. WT1 expression was not seen. Weak but still exceeding background staining was observed in predominantly cytoplasmic fashion with few scattered positive nuclei in transitional cell nest of the benign component. No reactivity, however, was seen within the proliferative component. The histopathological diagnosis was a borderline/atypical proliferative Brenner tumor. The patient has been regularly followed up and is at present disease-free 5 years after diagnosis. In this paper, the authors describe the morphological characteristics of Brenner tumors and address some debatable issues in the light of recent immunohistochemical and molecular studies. |
| format | Article |
| id | doaj-art-d4ce42e0612d4eb4870e0fc1a95e69e2 |
| institution | Kabale University |
| issn | 1313-9053 |
| language | English |
| publishDate | 2016-09-01 |
| publisher | Medical University - Pleven |
| record_format | Article |
| series | Journal of Biomedical & Clinical Research |
| spelling | doaj-art-d4ce42e0612d4eb4870e0fc1a95e69e22025-08-20T03:35:29ZengMedical University - PlevenJournal of Biomedical & Clinical Research1313-90532016-09-0191808410.1515/jbcr-2016-001234422Ovarian Brenner Tumors Revisited: Do We Have Space for Malignant Tumorsvand MethanolVesela IvanovaMilen KaraivanovTihomir DikovWe present a case of a 75-year-old female who underwent a total abdominal hysterectomy with bilateral salpingooophorectomy for an ovarian tumor. Hematoxylin-eosin- stained slides from tumor specimen revealed 1) focci of benign Brenner tumor; 2) mucinous cysts and 3) intracystic papillary projections resembling low-grade papillary transitional cell carcinoma (Grade 1-2) with squamous differentiation and comedo-type necrosis; 4) focal areas resembling noninvasive papillary transitional cell carcinoma Grade 3. Immunohistochemical investigation with a panel of antibodies (p63, p53, Ki-67, Wilms Tumor 1 - WT1, pi 6) was initiated. Areas resembling urothelial carcinoma showed diffuse nuclear positive reaction for p63 and wild-type expression of p53. Ki-67-nuclear positivity varied from less than 5% up to 30% in areas resembling high-grade urothelial carcinoma. WT1 expression was not seen. Weak but still exceeding background staining was observed in predominantly cytoplasmic fashion with few scattered positive nuclei in transitional cell nest of the benign component. No reactivity, however, was seen within the proliferative component. The histopathological diagnosis was a borderline/atypical proliferative Brenner tumor. The patient has been regularly followed up and is at present disease-free 5 years after diagnosis. In this paper, the authors describe the morphological characteristics of Brenner tumors and address some debatable issues in the light of recent immunohistochemical and molecular studies.https://jbcr.arphahub.com/article/34422/download/pdf/borderline/atypical proliferative Brenner tumorh |
| spellingShingle | Vesela Ivanova Milen Karaivanov Tihomir Dikov Ovarian Brenner Tumors Revisited: Do We Have Space for Malignant Tumorsvand Methanol Journal of Biomedical & Clinical Research borderline/atypical proliferative Brenner tumor h |
| title | Ovarian Brenner Tumors Revisited: Do We Have Space for Malignant Tumorsvand Methanol |
| title_full | Ovarian Brenner Tumors Revisited: Do We Have Space for Malignant Tumorsvand Methanol |
| title_fullStr | Ovarian Brenner Tumors Revisited: Do We Have Space for Malignant Tumorsvand Methanol |
| title_full_unstemmed | Ovarian Brenner Tumors Revisited: Do We Have Space for Malignant Tumorsvand Methanol |
| title_short | Ovarian Brenner Tumors Revisited: Do We Have Space for Malignant Tumorsvand Methanol |
| title_sort | ovarian brenner tumors revisited do we have space for malignant tumorsvand methanol |
| topic | borderline/atypical proliferative Brenner tumor h |
| url | https://jbcr.arphahub.com/article/34422/download/pdf/ |
| work_keys_str_mv | AT veselaivanova ovarianbrennertumorsrevisiteddowehavespaceformalignanttumorsvandmethanol AT milenkaraivanov ovarianbrennertumorsrevisiteddowehavespaceformalignanttumorsvandmethanol AT tihomirdikov ovarianbrennertumorsrevisiteddowehavespaceformalignanttumorsvandmethanol |