A novel scaffold-free mesenchymal stem cell-derived tissue engineered construct for articular cartilage restoration - From basic to clinic
Treatments for articular cartilage injuries are still challenging, due in part to its avascular and aneural surroundings. Since the first report of autologous chondrocyte implantation, cell-based therapies have been extensively studied with a variety of cell sources, including chondrocytes and mesen...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Regenerative Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320424000944 |
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| author | Kazunori Shimomura Wataru Ando David A. Hart Norimasa Nakamura |
| author_facet | Kazunori Shimomura Wataru Ando David A. Hart Norimasa Nakamura |
| author_sort | Kazunori Shimomura |
| collection | DOAJ |
| description | Treatments for articular cartilage injuries are still challenging, due in part to its avascular and aneural surroundings. Since the first report of autologous chondrocyte implantation, cell-based therapies have been extensively studied with a variety of cell sources, including chondrocytes and mesenchymal stem/stromal cells (MSCs). Recently, MSC-based therapy has received considerable research attention because of the relative ease in handling for tissue harvest, and subsequent cell expansion and differentiation. Using such cells, we have originally developed a 3-dimensional scaffold-free tissue-engineered construct (TEC) through simple-cell culture methods and demonstrated its feasibility for cartilage repair and regeneration in the first-in-human clinical trial. This review summarizes our novel scaffold-free approaches to use MSC for the restoration of damaged articular cartilage, documenting the progression from basic to clinical studies. |
| format | Article |
| id | doaj-art-d4caba76b41c48ea94fdd00b1c9d56b7 |
| institution | DOAJ |
| issn | 2352-3204 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj-art-d4caba76b41c48ea94fdd00b1c9d56b72025-08-20T02:48:58ZengElsevierRegenerative Therapy2352-32042024-06-012612413110.1016/j.reth.2024.05.007A novel scaffold-free mesenchymal stem cell-derived tissue engineered construct for articular cartilage restoration - From basic to clinicKazunori Shimomura0Wataru Ando1David A. Hart2Norimasa Nakamura3Department of Rehabilitation, Kansai University of Welfare Sciences, Osaka, Japan; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan; Corresponding author. Department of Rehabilitation, Kansai University of Welfare Sciences, 3-11-37 Asahigaoka, Kashiwara-city, Osaka 582-0026, Japan.Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan; Department of Orthopaedic Surgery, Kansai Rosai Hospital, Hyogo, JapanMcCaig Institute for Bone & Joint Health, University of Calgary, Calgary, Alberta, CanadaDepartment of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan; Institute for Medical Science in Sports, Osaka Health Science University, Osaka, Japan; Global Center for Medical Engineering and Informatics, Osaka University, Osaka, JapanTreatments for articular cartilage injuries are still challenging, due in part to its avascular and aneural surroundings. Since the first report of autologous chondrocyte implantation, cell-based therapies have been extensively studied with a variety of cell sources, including chondrocytes and mesenchymal stem/stromal cells (MSCs). Recently, MSC-based therapy has received considerable research attention because of the relative ease in handling for tissue harvest, and subsequent cell expansion and differentiation. Using such cells, we have originally developed a 3-dimensional scaffold-free tissue-engineered construct (TEC) through simple-cell culture methods and demonstrated its feasibility for cartilage repair and regeneration in the first-in-human clinical trial. This review summarizes our novel scaffold-free approaches to use MSC for the restoration of damaged articular cartilage, documenting the progression from basic to clinical studies.http://www.sciencedirect.com/science/article/pii/S2352320424000944Cartilage repairMesenchymal stem/stromal cellScaffold freeSynovium |
| spellingShingle | Kazunori Shimomura Wataru Ando David A. Hart Norimasa Nakamura A novel scaffold-free mesenchymal stem cell-derived tissue engineered construct for articular cartilage restoration - From basic to clinic Regenerative Therapy Cartilage repair Mesenchymal stem/stromal cell Scaffold free Synovium |
| title | A novel scaffold-free mesenchymal stem cell-derived tissue engineered construct for articular cartilage restoration - From basic to clinic |
| title_full | A novel scaffold-free mesenchymal stem cell-derived tissue engineered construct for articular cartilage restoration - From basic to clinic |
| title_fullStr | A novel scaffold-free mesenchymal stem cell-derived tissue engineered construct for articular cartilage restoration - From basic to clinic |
| title_full_unstemmed | A novel scaffold-free mesenchymal stem cell-derived tissue engineered construct for articular cartilage restoration - From basic to clinic |
| title_short | A novel scaffold-free mesenchymal stem cell-derived tissue engineered construct for articular cartilage restoration - From basic to clinic |
| title_sort | novel scaffold free mesenchymal stem cell derived tissue engineered construct for articular cartilage restoration from basic to clinic |
| topic | Cartilage repair Mesenchymal stem/stromal cell Scaffold free Synovium |
| url | http://www.sciencedirect.com/science/article/pii/S2352320424000944 |
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