Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses
Recently, it has become clear that atherosclerosis is a chronic inflammatory disease in which inflammation and immune responses play a key role. Accelerated atherosclerosis has been reported in patients with autoimmune diseases, suggesting an involvement of autoimmune mechanisms in atherogenesis. Di...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.4061/2011/295705 |
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| author | Elisabetta Profumo Brigitta Buttari Rachele Riganò |
| author_facet | Elisabetta Profumo Brigitta Buttari Rachele Riganò |
| author_sort | Elisabetta Profumo |
| collection | DOAJ |
| description | Recently, it has become clear that atherosclerosis is a chronic inflammatory disease in which inflammation and immune responses play a key role. Accelerated atherosclerosis has been reported in patients with autoimmune diseases, suggesting an involvement of autoimmune mechanisms in atherogenesis. Different self-antigens or modified self-molecules have been identified as target of humoral and cellular immune responses in patients with atherosclerotic disease. Oxidative stress, increasingly reported in these patients, is the major event causing structural modification of proteins with consequent appearance of neoepitopes. Self-molecules modified by oxidative events can become targets of autoimmune reactions, thus sustaining the inflammatory mechanisms involved in endothelial dysfunction and plaque development. In this paper, we will summarize the best characterized autoantigens in atherosclerosis and their possible role in cardiovascular inflammation. |
| format | Article |
| id | doaj-art-d4c3169766d64f39975489d558ee5462 |
| institution | Kabale University |
| issn | 2042-0099 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-d4c3169766d64f39975489d558ee54622025-02-03T07:25:08ZengWileyInternational Journal of Inflammation2042-00992011-01-01201110.4061/2011/295705295705Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune ResponsesElisabetta Profumo0Brigitta Buttari1Rachele Riganò2Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, ItalyDipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, ItalyDipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, ItalyRecently, it has become clear that atherosclerosis is a chronic inflammatory disease in which inflammation and immune responses play a key role. Accelerated atherosclerosis has been reported in patients with autoimmune diseases, suggesting an involvement of autoimmune mechanisms in atherogenesis. Different self-antigens or modified self-molecules have been identified as target of humoral and cellular immune responses in patients with atherosclerotic disease. Oxidative stress, increasingly reported in these patients, is the major event causing structural modification of proteins with consequent appearance of neoepitopes. Self-molecules modified by oxidative events can become targets of autoimmune reactions, thus sustaining the inflammatory mechanisms involved in endothelial dysfunction and plaque development. In this paper, we will summarize the best characterized autoantigens in atherosclerosis and their possible role in cardiovascular inflammation.http://dx.doi.org/10.4061/2011/295705 |
| spellingShingle | Elisabetta Profumo Brigitta Buttari Rachele Riganò Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses International Journal of Inflammation |
| title | Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses |
| title_full | Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses |
| title_fullStr | Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses |
| title_full_unstemmed | Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses |
| title_short | Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses |
| title_sort | oxidative stress in cardiovascular inflammation its involvement in autoimmune responses |
| url | http://dx.doi.org/10.4061/2011/295705 |
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