The Effect of Negative Poisson’s Ratio Polyurethane Scaffolds for Articular Cartilage Tissue Engineering Applications
An auxetic polyurethane (PU) scaffold was prepared to investigate chondrocyte proliferation under compressive stimulation for cartilage regeneration. To give a negative Poisson’s ratio to the PU scaffold, volumetric compression with a 3 : 1 ratio was applied during heat treatment. For the control PU...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Advances in Materials Science and Engineering |
| Online Access: | http://dx.doi.org/10.1155/2013/853289 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850172825159073792 |
|---|---|
| author | Yeong Jun Park Jeong Koo Kim |
| author_facet | Yeong Jun Park Jeong Koo Kim |
| author_sort | Yeong Jun Park |
| collection | DOAJ |
| description | An auxetic polyurethane (PU) scaffold was prepared to investigate chondrocyte proliferation under compressive stimulation for cartilage regeneration. To give a negative Poisson’s ratio to the PU scaffold, volumetric compression with a 3 : 1 ratio was applied during heat treatment. For the control PU scaffold, the Poisson’s ratio was 0.9 ± 0.25 with elongation at 20% of the strain range. Poisson’s ratio for experimental specimens was approximately −0.4 ± 0.12 under the same conditions. In cell proliferation tests, cells were cultivated within the prepared scaffold under compression with a 20% strain range. With a 20% strain range elongation, the compressive load was approximately 0.3 N. The experimental group showed a 1.3 times higher cellular proliferation rate than that of the control group after 3 days in culture. At day 5 of culture, however, the rate of proliferation of the control group increased so that there was no significant difference between groups. However, collagen content (produced by the cells) in the cell-proliferated medium was 1.5 times higher in the experimental group after 5 days in culture. This may have been due to the effectiveness of the auxetic structure of the scaffold. An isotropic compressive load was transmitted to the cells due to the negative Poisson ratio of the scaffold. |
| format | Article |
| id | doaj-art-d4c041180c784c57bf8160e2b4e52bc7 |
| institution | OA Journals |
| issn | 1687-8434 1687-8442 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Materials Science and Engineering |
| spelling | doaj-art-d4c041180c784c57bf8160e2b4e52bc72025-08-20T02:19:58ZengWileyAdvances in Materials Science and Engineering1687-84341687-84422013-01-01201310.1155/2013/853289853289The Effect of Negative Poisson’s Ratio Polyurethane Scaffolds for Articular Cartilage Tissue Engineering ApplicationsYeong Jun Park0Jeong Koo Kim1Department of Biomedical Engineering, Graduate School, Inje University, Gimhae 621-749, Republic of KoreaDepartment of Biomedical Engineering, Graduate School, Inje University, Gimhae 621-749, Republic of KoreaAn auxetic polyurethane (PU) scaffold was prepared to investigate chondrocyte proliferation under compressive stimulation for cartilage regeneration. To give a negative Poisson’s ratio to the PU scaffold, volumetric compression with a 3 : 1 ratio was applied during heat treatment. For the control PU scaffold, the Poisson’s ratio was 0.9 ± 0.25 with elongation at 20% of the strain range. Poisson’s ratio for experimental specimens was approximately −0.4 ± 0.12 under the same conditions. In cell proliferation tests, cells were cultivated within the prepared scaffold under compression with a 20% strain range. With a 20% strain range elongation, the compressive load was approximately 0.3 N. The experimental group showed a 1.3 times higher cellular proliferation rate than that of the control group after 3 days in culture. At day 5 of culture, however, the rate of proliferation of the control group increased so that there was no significant difference between groups. However, collagen content (produced by the cells) in the cell-proliferated medium was 1.5 times higher in the experimental group after 5 days in culture. This may have been due to the effectiveness of the auxetic structure of the scaffold. An isotropic compressive load was transmitted to the cells due to the negative Poisson ratio of the scaffold.http://dx.doi.org/10.1155/2013/853289 |
| spellingShingle | Yeong Jun Park Jeong Koo Kim The Effect of Negative Poisson’s Ratio Polyurethane Scaffolds for Articular Cartilage Tissue Engineering Applications Advances in Materials Science and Engineering |
| title | The Effect of Negative Poisson’s Ratio Polyurethane Scaffolds for Articular Cartilage Tissue Engineering Applications |
| title_full | The Effect of Negative Poisson’s Ratio Polyurethane Scaffolds for Articular Cartilage Tissue Engineering Applications |
| title_fullStr | The Effect of Negative Poisson’s Ratio Polyurethane Scaffolds for Articular Cartilage Tissue Engineering Applications |
| title_full_unstemmed | The Effect of Negative Poisson’s Ratio Polyurethane Scaffolds for Articular Cartilage Tissue Engineering Applications |
| title_short | The Effect of Negative Poisson’s Ratio Polyurethane Scaffolds for Articular Cartilage Tissue Engineering Applications |
| title_sort | effect of negative poisson s ratio polyurethane scaffolds for articular cartilage tissue engineering applications |
| url | http://dx.doi.org/10.1155/2013/853289 |
| work_keys_str_mv | AT yeongjunpark theeffectofnegativepoissonsratiopolyurethanescaffoldsforarticularcartilagetissueengineeringapplications AT jeongkookim theeffectofnegativepoissonsratiopolyurethanescaffoldsforarticularcartilagetissueengineeringapplications AT yeongjunpark effectofnegativepoissonsratiopolyurethanescaffoldsforarticularcartilagetissueengineeringapplications AT jeongkookim effectofnegativepoissonsratiopolyurethanescaffoldsforarticularcartilagetissueengineeringapplications |