SREBP-2 promotes cancer progression through the mevalonate-Akt pathway in non-small cell lung cancer

SREBP-2 promotes cancer progression through the mevalonate-Akt pathway in non-small cell lung cancer

Abstract Sterol regulatory element-binding protein-2 (SREBP-2) is a transcriptional factor, which mainly regulates cholesterogenesis-associated genes. The metabolism of cholesterol was found to be abnormal in non-small cell lung cancer (NSCLC). However, the clinical relevance of SREBP-2 in NSCLC has...

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Bibliographic Details
Main Authors: Wenjie You, Lili Su, Shuping Weng, Jing Li, Xingguang Wang, Bin Liang, Daowei Li, Lijun Li, Haiquan Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Sterol regulatory element-binding protein-2
Cholesterol metabolism
Non-small cell lung cancer
Prognostic indicator
Akt signaling pathway
Online Access:https://doi.org/10.1038/s41598-025-07437-0
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