Evaluation of Ki-67 expression levels in esophageal squamous cell carcinoma using dual-energy CT quantitative parameters
AimThis study investigates the use of dual-energy computed tomography (DECT) quantitative parameters to assess Ki-67 expression levels in esophageal squamous cell carcinoma (ESCC).MethodsA total of 57 ESCC patients who underwent dual-phase DECT scans were included. Key parameters measured were iodin...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1561256/full |
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| author | Jing Sun Yong-ying Huang Tao Lu Xing-fa Chen Hui-ping Ruan De-chun Zheng |
| author_facet | Jing Sun Yong-ying Huang Tao Lu Xing-fa Chen Hui-ping Ruan De-chun Zheng |
| author_sort | Jing Sun |
| collection | DOAJ |
| description | AimThis study investigates the use of dual-energy computed tomography (DECT) quantitative parameters to assess Ki-67 expression levels in esophageal squamous cell carcinoma (ESCC).MethodsA total of 57 ESCC patients who underwent dual-phase DECT scans were included. Key parameters measured were iodine concentration (IC), water concentration (WC), normalized iodine concentration (NIC), spectral Hounsfield unit curve slope (λHu), and effective atomic number (Zeff). Univariate and multivariate analyses identified factors associated with Ki-67 expression levels.ResultsResults showed that high Ki-67 expression correlated with significantly higher Zeff and IC values in the venous phase (VP) (P = 0.047 and P = 0.049, respectively; AUC = 0.67 for both), and lower WC in the arterial phase (AP) (P = 0.021; AUC = 0.70). Multivariate analysis revealed that IC in VP and WC in AP were independent predictors of Ki-67 overexpression. The combination of these two parameters yielded an AUC of 0.78 for predicting Ki-67 overexpression, with 68.3% sensitivity, 87.5% specificity, and 73.7% accuracy.ConclusionsDECT parameters demonstrate potential for non-invasive Ki-67 status detection in ESCC, offering valuable insights for clinical diagnosis and prognosis. |
| format | Article |
| id | doaj-art-d4b8a2527c4e4d0493113e67522ea031 |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-d4b8a2527c4e4d0493113e67522ea0312025-08-20T02:57:30ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-08-011510.3389/fonc.2025.15612561561256Evaluation of Ki-67 expression levels in esophageal squamous cell carcinoma using dual-energy CT quantitative parametersJing Sun0Yong-ying Huang1Tao Lu2Xing-fa Chen3Hui-ping Ruan4De-chun Zheng5Department of Radiology, Clinical Oncology School of Fujian Medical University and Fujian Cancer Hospital (Fujian Branch of Fudan University Affiliated Cancer Hospital), Fuzhou, Fujian, ChinaDepartment of Epidemiology, Clinical Oncology School of Fujian Medical University and Fujian Cancer Hospital (Fujian Branch of Fudan University Affiliated Cancer Hospital), Fuzhou, Fujian, ChinaDepartment of Radiology, Clinical Oncology School of Fujian Medical University and Fujian Cancer Hospital (Fujian Branch of Fudan University Affiliated Cancer Hospital), Fuzhou, Fujian, ChinaDepartment of Radiology, Clinical Oncology School of Fujian Medical University and Fujian Cancer Hospital (Fujian Branch of Fudan University Affiliated Cancer Hospital), Fuzhou, Fujian, ChinaDepartment of Radiology, Clinical Oncology School of Fujian Medical University and Fujian Cancer Hospital (Fujian Branch of Fudan University Affiliated Cancer Hospital), Fuzhou, Fujian, ChinaDepartment of Radiology, Clinical Oncology School of Fujian Medical University and Fujian Cancer Hospital (Fujian Branch of Fudan University Affiliated Cancer Hospital), Fuzhou, Fujian, ChinaAimThis study investigates the use of dual-energy computed tomography (DECT) quantitative parameters to assess Ki-67 expression levels in esophageal squamous cell carcinoma (ESCC).MethodsA total of 57 ESCC patients who underwent dual-phase DECT scans were included. Key parameters measured were iodine concentration (IC), water concentration (WC), normalized iodine concentration (NIC), spectral Hounsfield unit curve slope (λHu), and effective atomic number (Zeff). Univariate and multivariate analyses identified factors associated with Ki-67 expression levels.ResultsResults showed that high Ki-67 expression correlated with significantly higher Zeff and IC values in the venous phase (VP) (P = 0.047 and P = 0.049, respectively; AUC = 0.67 for both), and lower WC in the arterial phase (AP) (P = 0.021; AUC = 0.70). Multivariate analysis revealed that IC in VP and WC in AP were independent predictors of Ki-67 overexpression. The combination of these two parameters yielded an AUC of 0.78 for predicting Ki-67 overexpression, with 68.3% sensitivity, 87.5% specificity, and 73.7% accuracy.ConclusionsDECT parameters demonstrate potential for non-invasive Ki-67 status detection in ESCC, offering valuable insights for clinical diagnosis and prognosis.https://www.frontiersin.org/articles/10.3389/fonc.2025.1561256/fullquantitative parametersKi-67 expressiondual-energy CT (DECT)esophageal squamous cell carcinomanomogram |
| spellingShingle | Jing Sun Yong-ying Huang Tao Lu Xing-fa Chen Hui-ping Ruan De-chun Zheng Evaluation of Ki-67 expression levels in esophageal squamous cell carcinoma using dual-energy CT quantitative parameters Frontiers in Oncology quantitative parameters Ki-67 expression dual-energy CT (DECT) esophageal squamous cell carcinoma nomogram |
| title | Evaluation of Ki-67 expression levels in esophageal squamous cell carcinoma using dual-energy CT quantitative parameters |
| title_full | Evaluation of Ki-67 expression levels in esophageal squamous cell carcinoma using dual-energy CT quantitative parameters |
| title_fullStr | Evaluation of Ki-67 expression levels in esophageal squamous cell carcinoma using dual-energy CT quantitative parameters |
| title_full_unstemmed | Evaluation of Ki-67 expression levels in esophageal squamous cell carcinoma using dual-energy CT quantitative parameters |
| title_short | Evaluation of Ki-67 expression levels in esophageal squamous cell carcinoma using dual-energy CT quantitative parameters |
| title_sort | evaluation of ki 67 expression levels in esophageal squamous cell carcinoma using dual energy ct quantitative parameters |
| topic | quantitative parameters Ki-67 expression dual-energy CT (DECT) esophageal squamous cell carcinoma nomogram |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1561256/full |
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