PRMT6 promotes colorectal cancer progress via activating MYC signaling
Abstract Colorectal cancer (CRC) remains a major global health challenge, with high rates of incidence and mortality. This study investigates the role of protein arginine methyltransferase 6 (PRMT6) as an oncogene in CRC and its mechanistic involvement in tumor progression. We found that PRMT6 is si...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06097-y |
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| _version_ | 1832594513339613184 |
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| author | Xin Zhang Mingxin Jin Yali Chu Fengjun Liu Hui Qu Cheng Chen |
| author_facet | Xin Zhang Mingxin Jin Yali Chu Fengjun Liu Hui Qu Cheng Chen |
| author_sort | Xin Zhang |
| collection | DOAJ |
| description | Abstract Colorectal cancer (CRC) remains a major global health challenge, with high rates of incidence and mortality. This study investigates the role of protein arginine methyltransferase 6 (PRMT6) as an oncogene in CRC and its mechanistic involvement in tumor progression. We found that PRMT6 is significantly overexpressed in CRC tissues compared to adjacent normal tissues and is associated with poorer patient survival. Functional assays demonstrated that PRMT6 promotes CRC cell proliferation, migration, and invasion. Mechanistically, PRMT6 enhances MYC signaling by stabilizing c-MYC through mono-methylation at arginine 371, which inhibits c-MYC poly-ubiquitination and subsequent degradation. This post-translational modification is crucial for PRMT6-induced cancer cell proliferation. Xenograft models further validated that PRMT6 knockdown results in reduced tumor growth and decreased c-MYC levels. Our findings highlight PRMT6 as a key regulator of c-MYC stability and CRC progression, suggesting that targeting PRMT6 or its effects on c-MYC could offer a promising strategy for CRC treatment. |
| format | Article |
| id | doaj-art-d4b6a92968ad43b3909793ac303c11ff |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-d4b6a92968ad43b3909793ac303c11ff2025-01-19T12:37:05ZengBMCJournal of Translational Medicine1479-58762025-01-0123111310.1186/s12967-025-06097-yPRMT6 promotes colorectal cancer progress via activating MYC signalingXin Zhang0Mingxin Jin1Yali Chu2Fengjun Liu3Hui Qu4Cheng Chen5Department of General Surgery, Qilu Hospital of Shandong UniversityDepartment of General Surgery, Qilu Hospital of Shandong UniversityDepartment of General Surgery, Qilu Hospital of Shandong UniversityDepartment of General Surgery, Qilu Hospital of Shandong UniversityDepartment of General Surgery, Qilu Hospital of Shandong UniversityDepartment of General Surgery, Qilu Hospital of Shandong UniversityAbstract Colorectal cancer (CRC) remains a major global health challenge, with high rates of incidence and mortality. This study investigates the role of protein arginine methyltransferase 6 (PRMT6) as an oncogene in CRC and its mechanistic involvement in tumor progression. We found that PRMT6 is significantly overexpressed in CRC tissues compared to adjacent normal tissues and is associated with poorer patient survival. Functional assays demonstrated that PRMT6 promotes CRC cell proliferation, migration, and invasion. Mechanistically, PRMT6 enhances MYC signaling by stabilizing c-MYC through mono-methylation at arginine 371, which inhibits c-MYC poly-ubiquitination and subsequent degradation. This post-translational modification is crucial for PRMT6-induced cancer cell proliferation. Xenograft models further validated that PRMT6 knockdown results in reduced tumor growth and decreased c-MYC levels. Our findings highlight PRMT6 as a key regulator of c-MYC stability and CRC progression, suggesting that targeting PRMT6 or its effects on c-MYC could offer a promising strategy for CRC treatment.https://doi.org/10.1186/s12967-025-06097-yColorectal cancerPRMT6c-MYC |
| spellingShingle | Xin Zhang Mingxin Jin Yali Chu Fengjun Liu Hui Qu Cheng Chen PRMT6 promotes colorectal cancer progress via activating MYC signaling Journal of Translational Medicine Colorectal cancer PRMT6 c-MYC |
| title | PRMT6 promotes colorectal cancer progress via activating MYC signaling |
| title_full | PRMT6 promotes colorectal cancer progress via activating MYC signaling |
| title_fullStr | PRMT6 promotes colorectal cancer progress via activating MYC signaling |
| title_full_unstemmed | PRMT6 promotes colorectal cancer progress via activating MYC signaling |
| title_short | PRMT6 promotes colorectal cancer progress via activating MYC signaling |
| title_sort | prmt6 promotes colorectal cancer progress via activating myc signaling |
| topic | Colorectal cancer PRMT6 c-MYC |
| url | https://doi.org/10.1186/s12967-025-06097-y |
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