Design, Synthesis of Some New Quinazolinone Derivatives and Evaluation of their Antibacterial Activity
The novel quinazolinone derivatives were synthesized in excellent yields, manufactured, characterized, and investigated for their biological activity. This study aims to produce new quinazolinone derivatives and study their antibacterial activity. Quinazolinone derivatives were synthesized in...
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| Format: | Article |
| Language: | English |
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University of Baghdad
2025-07-01
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| Series: | Ibn Al-Haitham Journal for Pure and Applied Sciences |
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| Online Access: | https://jih.uobaghdad.edu.iq/index.php/j/article/view/3620 |
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| author | Aseel Jassim Mohammed Oday H.R. Al-Jeilawi |
| author_facet | Aseel Jassim Mohammed Oday H.R. Al-Jeilawi |
| author_sort | Aseel Jassim Mohammed |
| collection | DOAJ |
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The novel quinazolinone derivatives were synthesized in excellent yields, manufactured, characterized, and investigated for their biological activity. This study aims to produce new quinazolinone derivatives and study their antibacterial activity. Quinazolinone derivatives were synthesized in three steps: the first step included the reaction of methyl anthranilate with isothiocyanatobenzene to produce a thiourea derivative (A1). In the second step (A1) was reacted with hydrazine hydrate to synthesized 3-Amino-2-(phenylamino) quinazolin-4(3H)-one (A2). The third step consisted of the reaction of (A2) with various organic compounds (phenylisotiocyanate, phenylisocyanate, acid halide, benzyl halide, and alkyl halide derivatives) to produce new derivatives. FT-IR, 1HNMR, and 13C NMR spectroscopy were used to identify the chemical structure of these compounds. The agar well diffusion technique was used to determine the antibacterial activity levels exhibited by the samples. Staphylococcus aureus and Escherichia coli were used as test organisms in this study. When compared to the antibiotic used as a standard, amikacin, these compounds demonstrated superior antibacterial activity.
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| format | Article |
| id | doaj-art-d4b5b9f3aca44e5eb0562b0acd41ffd6 |
| institution | Kabale University |
| issn | 1609-4042 2521-3407 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | University of Baghdad |
| record_format | Article |
| series | Ibn Al-Haitham Journal for Pure and Applied Sciences |
| spelling | doaj-art-d4b5b9f3aca44e5eb0562b0acd41ffd62025-08-20T03:51:19ZengUniversity of BaghdadIbn Al-Haitham Journal for Pure and Applied Sciences1609-40422521-34072025-07-0138310.30526/38.3.3620Design, Synthesis of Some New Quinazolinone Derivatives and Evaluation of their Antibacterial ActivityAseel Jassim Mohammed0https://orcid.org/0009-0000-7295-5269Oday H.R. Al-Jeilawi1https://orcid.org/0000-0002-4092-2072Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq. Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq. The novel quinazolinone derivatives were synthesized in excellent yields, manufactured, characterized, and investigated for their biological activity. This study aims to produce new quinazolinone derivatives and study their antibacterial activity. Quinazolinone derivatives were synthesized in three steps: the first step included the reaction of methyl anthranilate with isothiocyanatobenzene to produce a thiourea derivative (A1). In the second step (A1) was reacted with hydrazine hydrate to synthesized 3-Amino-2-(phenylamino) quinazolin-4(3H)-one (A2). The third step consisted of the reaction of (A2) with various organic compounds (phenylisotiocyanate, phenylisocyanate, acid halide, benzyl halide, and alkyl halide derivatives) to produce new derivatives. FT-IR, 1HNMR, and 13C NMR spectroscopy were used to identify the chemical structure of these compounds. The agar well diffusion technique was used to determine the antibacterial activity levels exhibited by the samples. Staphylococcus aureus and Escherichia coli were used as test organisms in this study. When compared to the antibiotic used as a standard, amikacin, these compounds demonstrated superior antibacterial activity. https://jih.uobaghdad.edu.iq/index.php/j/article/view/3620Antibacterial activity, Methyl anthranilate, Thiourea derivative, Quinazolinone derivatives |
| spellingShingle | Aseel Jassim Mohammed Oday H.R. Al-Jeilawi Design, Synthesis of Some New Quinazolinone Derivatives and Evaluation of their Antibacterial Activity Ibn Al-Haitham Journal for Pure and Applied Sciences Antibacterial activity, Methyl anthranilate, Thiourea derivative, Quinazolinone derivatives |
| title | Design, Synthesis of Some New Quinazolinone Derivatives and Evaluation of their Antibacterial Activity |
| title_full | Design, Synthesis of Some New Quinazolinone Derivatives and Evaluation of their Antibacterial Activity |
| title_fullStr | Design, Synthesis of Some New Quinazolinone Derivatives and Evaluation of their Antibacterial Activity |
| title_full_unstemmed | Design, Synthesis of Some New Quinazolinone Derivatives and Evaluation of their Antibacterial Activity |
| title_short | Design, Synthesis of Some New Quinazolinone Derivatives and Evaluation of their Antibacterial Activity |
| title_sort | design synthesis of some new quinazolinone derivatives and evaluation of their antibacterial activity |
| topic | Antibacterial activity, Methyl anthranilate, Thiourea derivative, Quinazolinone derivatives |
| url | https://jih.uobaghdad.edu.iq/index.php/j/article/view/3620 |
| work_keys_str_mv | AT aseeljassimmohammed designsynthesisofsomenewquinazolinonederivativesandevaluationoftheirantibacterialactivity AT odayhraljeilawi designsynthesisofsomenewquinazolinonederivativesandevaluationoftheirantibacterialactivity |