Antibiotic resistance profile of Acinetobacter baumannii isolates identified from blood cultures
Background: Acinetobacter baumannii (A. baumannii) has emerged as the predominant etiological agent responsible for bloodstream infections among hospitalized patients. The objective of this study was to evaluate antibiotic resistance in A. baumannii isolates identified from blood cultures. Methods:...
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Golestan University of Medical Sciences
2024-07-01
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| Series: | Medical Laboratory Journal |
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| Online Access: | http://mlj.goums.ac.ir/article-1-1692-en.pdf |
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| author | Zaid Faris Hasan Umut Safiye Şay Coşkun |
| author_facet | Zaid Faris Hasan Umut Safiye Şay Coşkun |
| author_sort | Zaid Faris Hasan |
| collection | DOAJ |
| description | Background: Acinetobacter baumannii (A. baumannii) has emerged as the predominant etiological agent responsible for bloodstream infections among hospitalized patients. The objective of this study was to evaluate antibiotic resistance in A. baumannii isolates identified from blood cultures.
Methods: A retrospective cohort evaluation was conducted on 117 A. baumannii isolates obtained from blood cultures collected between 2018 and 2019 at the Microbiology Laboratory of Tokat Gaziosmanpaşa University Hospital (Türkiye). The blood culture samples were incubated using the BACT-ALERT 3D system (bioMérieux, Durham, NC, USA). Microorganism identification and antibiotic susceptibility testing were performed using the VITEK 2 (bioMérieux, France) automated system.
Results: Of the 117 samples, 59.8% were obtained from males and 40.2% from females. A total of 90.6% of blood culture samples were collected from the intensive care unit, and 88.9% of isolates were identified as multidrug-resistant (MDR). The highest resistance was observed against meropenem (99.1%), while the lowest resistance was noted for colistin (17.1%) and tigecycline (27.3%). Resistance to amikacin was 74.4%, while resistance levels to gentamicin, tobramycin, cefoxitin, and cefotaxime were within the range of 80–90%. Resistance to imipenem, amoxicillin/clavulanic acid, ampicillin/sulbactam, ceftazidime, cefepime, ciprofloxacin, levofloxacin, meropenem, and ertapenem exceeded 90%.
Conclusion: The increasing number of MDR A. baumannii isolates poses a significant threat to all hospitalized patients. However, colistin and tigecycline remain preferable options for the treatment of MDR A. baumannii infections. Considering the increasing prevalence of MDR A. baumannii isolates, periodic analysis of epidemiological data in healthcare centers is important for managing resistance to colistin and tigecycline. |
| format | Article |
| id | doaj-art-d4b468aeae0f453fa748c477f5a213c7 |
| institution | OA Journals |
| issn | 2538-4449 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | Medical Laboratory Journal |
| spelling | doaj-art-d4b468aeae0f453fa748c477f5a213c72025-08-20T02:25:35ZengGolestan University of Medical SciencesMedical Laboratory Journal2538-44492024-07-01184810Antibiotic resistance profile of Acinetobacter baumannii isolates identified from blood culturesZaid Faris Hasan0Umut Safiye Şay Coşkun1 Instutite of Graduate Studies, Tokat Gaziosmanpaşa University, Tokat, Turkey Department of Medical Microbiology, Faculty of Medicine, Tokat Gaziosmanpaşa University, Tokat, Turkey Background: Acinetobacter baumannii (A. baumannii) has emerged as the predominant etiological agent responsible for bloodstream infections among hospitalized patients. The objective of this study was to evaluate antibiotic resistance in A. baumannii isolates identified from blood cultures. Methods: A retrospective cohort evaluation was conducted on 117 A. baumannii isolates obtained from blood cultures collected between 2018 and 2019 at the Microbiology Laboratory of Tokat Gaziosmanpaşa University Hospital (Türkiye). The blood culture samples were incubated using the BACT-ALERT 3D system (bioMérieux, Durham, NC, USA). Microorganism identification and antibiotic susceptibility testing were performed using the VITEK 2 (bioMérieux, France) automated system. Results: Of the 117 samples, 59.8% were obtained from males and 40.2% from females. A total of 90.6% of blood culture samples were collected from the intensive care unit, and 88.9% of isolates were identified as multidrug-resistant (MDR). The highest resistance was observed against meropenem (99.1%), while the lowest resistance was noted for colistin (17.1%) and tigecycline (27.3%). Resistance to amikacin was 74.4%, while resistance levels to gentamicin, tobramycin, cefoxitin, and cefotaxime were within the range of 80–90%. Resistance to imipenem, amoxicillin/clavulanic acid, ampicillin/sulbactam, ceftazidime, cefepime, ciprofloxacin, levofloxacin, meropenem, and ertapenem exceeded 90%. Conclusion: The increasing number of MDR A. baumannii isolates poses a significant threat to all hospitalized patients. However, colistin and tigecycline remain preferable options for the treatment of MDR A. baumannii infections. Considering the increasing prevalence of MDR A. baumannii isolates, periodic analysis of epidemiological data in healthcare centers is important for managing resistance to colistin and tigecycline.http://mlj.goums.ac.ir/article-1-1692-en.pdfacinetobacter baumanniiblood culturecolistinmultiple drug resistancetigecycline |
| spellingShingle | Zaid Faris Hasan Umut Safiye Şay Coşkun Antibiotic resistance profile of Acinetobacter baumannii isolates identified from blood cultures Medical Laboratory Journal acinetobacter baumannii blood culture colistin multiple drug resistance tigecycline |
| title | Antibiotic resistance profile of Acinetobacter baumannii isolates identified from blood cultures |
| title_full | Antibiotic resistance profile of Acinetobacter baumannii isolates identified from blood cultures |
| title_fullStr | Antibiotic resistance profile of Acinetobacter baumannii isolates identified from blood cultures |
| title_full_unstemmed | Antibiotic resistance profile of Acinetobacter baumannii isolates identified from blood cultures |
| title_short | Antibiotic resistance profile of Acinetobacter baumannii isolates identified from blood cultures |
| title_sort | antibiotic resistance profile of acinetobacter baumannii isolates identified from blood cultures |
| topic | acinetobacter baumannii blood culture colistin multiple drug resistance tigecycline |
| url | http://mlj.goums.ac.ir/article-1-1692-en.pdf |
| work_keys_str_mv | AT zaidfarishasan antibioticresistanceprofileofacinetobacterbaumanniiisolatesidentifiedfrombloodcultures AT umutsafiyesaycoskun antibioticresistanceprofileofacinetobacterbaumanniiisolatesidentifiedfrombloodcultures |