Potential of quantitative flow ratio in guiding conduit selection between radial artery and saphenous vein graft for coronary artery bypass graftingCentral MessagePerspective
Objectives: Radial artery grafts and saphenous vein grafts exhibit heterogeneous responses to competitive flow, a phenomenon assessable through quantitative flow ratio. The present study aims to compare the patency of radial artery and saphenous vein grafts across various quantitative flow ratio ran...
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| Language: | English |
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Elsevier
2025-04-01
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| Series: | JTCVS Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666273625000476 |
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| author | Chunyuan Wang, MD Meice Tian, MD Yang Wang, PhD Lei Song, MD Zhihui Hou, MD Sipeng Chen, MS Wei Feng, MD Yan Zhang, MD Zhan Hu, MD |
| author_facet | Chunyuan Wang, MD Meice Tian, MD Yang Wang, PhD Lei Song, MD Zhihui Hou, MD Sipeng Chen, MS Wei Feng, MD Yan Zhang, MD Zhan Hu, MD |
| author_sort | Chunyuan Wang, MD |
| collection | DOAJ |
| description | Objectives: Radial artery grafts and saphenous vein grafts exhibit heterogeneous responses to competitive flow, a phenomenon assessable through quantitative flow ratio. The present study aims to compare the patency of radial artery and saphenous vein grafts across various quantitative flow ratio ranges. Methods: The clinical data and quantitative flow ratio values for each target vessel were retrospectively collected in patients receiving radial artery or conventional saphenous vein grafts in our center from 2017 to 2021. The primary outcome was graft occlusion assessed by coronary computed tomography angiography and coronary angiography, and the secondary outcome was major adverse cardiac or cerebrovascular events. Mixed-effect multivariable Cox regression models were used to assess the independent effect of graft conduit type and quantitative flow ratio on graft occlusion. Results: A total of 1314 patients with 292 radial artery target vessels and 1736 saphenous vein graft target vessels were included. The median follow-up duration was 3 years. Quantitative flow ratio value of 0.57 was identified as the optimal threshold. Compared with saphenous vein graft, the radial artery exhibited lower patency in target vessels where quantitative flow ratio was greater than 0.57 (adjusted hazard ratio, 4.63, 95% CI, 2.61-8.21, P < .001), but higher patency in vessels in which the quantitative flow ratio was 0.57 or less (adjusted hazard ratio, 0.14, 95% CI, 0.03-0.68, P = .015). Conclusions: Radial artery grafts may achieve superior patency in target vessels with low quantitative flow ratio values, whereas saphenous vein grafts may be associated with higher short-term patency in vessels with higher quantitative flow ratio values. |
| format | Article |
| id | doaj-art-d4b372d4ab724e738c7b27ff3bbf8361 |
| institution | OA Journals |
| issn | 2666-2736 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JTCVS Open |
| spelling | doaj-art-d4b372d4ab724e738c7b27ff3bbf83612025-08-20T02:12:07ZengElsevierJTCVS Open2666-27362025-04-012420621610.1016/j.xjon.2025.01.019Potential of quantitative flow ratio in guiding conduit selection between radial artery and saphenous vein graft for coronary artery bypass graftingCentral MessagePerspectiveChunyuan Wang, MD0Meice Tian, MD1Yang Wang, PhD2Lei Song, MD3Zhihui Hou, MD4Sipeng Chen, MS5Wei Feng, MD6Yan Zhang, MD7Zhan Hu, MD8Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Medical Research and Biometrics Center, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, National Clinical Research Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Radiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Information Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Address for reprints: Zhan Hu, MD, and Yan Zhang, MD, Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167A Beilishi Rd, Xi Cheng District, Beijing, 100037, China.Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Address for reprints: Zhan Hu, MD, and Yan Zhang, MD, Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167A Beilishi Rd, Xi Cheng District, Beijing, 100037, China.Objectives: Radial artery grafts and saphenous vein grafts exhibit heterogeneous responses to competitive flow, a phenomenon assessable through quantitative flow ratio. The present study aims to compare the patency of radial artery and saphenous vein grafts across various quantitative flow ratio ranges. Methods: The clinical data and quantitative flow ratio values for each target vessel were retrospectively collected in patients receiving radial artery or conventional saphenous vein grafts in our center from 2017 to 2021. The primary outcome was graft occlusion assessed by coronary computed tomography angiography and coronary angiography, and the secondary outcome was major adverse cardiac or cerebrovascular events. Mixed-effect multivariable Cox regression models were used to assess the independent effect of graft conduit type and quantitative flow ratio on graft occlusion. Results: A total of 1314 patients with 292 radial artery target vessels and 1736 saphenous vein graft target vessels were included. The median follow-up duration was 3 years. Quantitative flow ratio value of 0.57 was identified as the optimal threshold. Compared with saphenous vein graft, the radial artery exhibited lower patency in target vessels where quantitative flow ratio was greater than 0.57 (adjusted hazard ratio, 4.63, 95% CI, 2.61-8.21, P < .001), but higher patency in vessels in which the quantitative flow ratio was 0.57 or less (adjusted hazard ratio, 0.14, 95% CI, 0.03-0.68, P = .015). Conclusions: Radial artery grafts may achieve superior patency in target vessels with low quantitative flow ratio values, whereas saphenous vein grafts may be associated with higher short-term patency in vessels with higher quantitative flow ratio values.http://www.sciencedirect.com/science/article/pii/S2666273625000476angiography-derived coronary physiological assessmentcompetitive flowcoronary artery bypass graftingradial artery graftsaphenous vein graft |
| spellingShingle | Chunyuan Wang, MD Meice Tian, MD Yang Wang, PhD Lei Song, MD Zhihui Hou, MD Sipeng Chen, MS Wei Feng, MD Yan Zhang, MD Zhan Hu, MD Potential of quantitative flow ratio in guiding conduit selection between radial artery and saphenous vein graft for coronary artery bypass graftingCentral MessagePerspective JTCVS Open angiography-derived coronary physiological assessment competitive flow coronary artery bypass grafting radial artery graft saphenous vein graft |
| title | Potential of quantitative flow ratio in guiding conduit selection between radial artery and saphenous vein graft for coronary artery bypass graftingCentral MessagePerspective |
| title_full | Potential of quantitative flow ratio in guiding conduit selection between radial artery and saphenous vein graft for coronary artery bypass graftingCentral MessagePerspective |
| title_fullStr | Potential of quantitative flow ratio in guiding conduit selection between radial artery and saphenous vein graft for coronary artery bypass graftingCentral MessagePerspective |
| title_full_unstemmed | Potential of quantitative flow ratio in guiding conduit selection between radial artery and saphenous vein graft for coronary artery bypass graftingCentral MessagePerspective |
| title_short | Potential of quantitative flow ratio in guiding conduit selection between radial artery and saphenous vein graft for coronary artery bypass graftingCentral MessagePerspective |
| title_sort | potential of quantitative flow ratio in guiding conduit selection between radial artery and saphenous vein graft for coronary artery bypass graftingcentral messageperspective |
| topic | angiography-derived coronary physiological assessment competitive flow coronary artery bypass grafting radial artery graft saphenous vein graft |
| url | http://www.sciencedirect.com/science/article/pii/S2666273625000476 |
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