Comparative efficacy between Livolin forte® and Ocimum gratissimum on CCl 4 induced Liver damage in Wistar albino Rats.
In recent years, the incidence of liver disease has remained an important public health problem worldwide despite global attention to eradicate it. Both Livolin forte® (LIV) and extract of Ocimum gratissimum have been used separately as hepatoprotective agent. The aim of this study was to compare th...
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Hammer Head Production Limited
2020-12-01
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| Series: | Sokoto Journal of Medical Laboratory Science |
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| Online Access: | https://sokjmls.com.ng/index.php/SJMLS/article/view/114 |
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| author | Ighodaro, C.N. * , Ebo, O.E. and Agoreyo, F. |
| author_facet | Ighodaro, C.N. * , Ebo, O.E. and Agoreyo, F. |
| author_sort | Ighodaro, C.N. * , Ebo, O.E. and Agoreyo, F. |
| collection | DOAJ |
| description | In recent years, the incidence of liver disease has remained an important public health problem worldwide despite global attention to eradicate it. Both Livolin forte® (LIV) and extract of Ocimum gratissimum have been used separately as hepatoprotective agent. The aim of this study was to compare the efficacy of Livolin forte® and Ocimum gratissimum at ameliorating liver damage. Twenty-four albino Wistar rats weighing between 150-200 g were used. They were randomly distributed into six groups (6) comprising four animals in each group. Group 1 rats (normal control) received 0.3 ml/kg/day of propylene glycol, the vehicle in which LIV was dissolved, orally for 4 weeks. Group 2 (toxic) received CCl 4 , dissolved in olive oil (1:1 v/v) at 0.7 ml/kg for 7 alternating days, so as to induce liver damage. Group 3 (standard) were pre-treated as group 2 after which they received oral administration of Livolin forte® at 5.2 mg/kg for 4 consecutive weeks and Group 4, 5 and 6 were pre-treated as group 2 and thereafter received oral graded doses of the extract at 100 mg/kg, 200 mg/kg and 400 mg/kg respectively for 4 consecutive weeks. The result showed that Livolin forte® group, pretreated with CCl 4 (Group 3) has a lower level of Serum Bilirubin, AST, ALT and ALP when compared with the extract of Ocimum gratissimum treated groups (Group 4, 5 and 6). However, this was statistically significant (p>0.05). In conclusion, Livolin forte® was better as a curative agent than Ocimum gratissimum extract in rats. It showed a higher level of efficacy on CCl 4 induced liver damage. This supports the use of the drug for treating hepatic damage in humans. |
| format | Article |
| id | doaj-art-d4af49ade03f4c858f98e52dc754b3ea |
| institution | Kabale University |
| issn | 2536-7153 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | Hammer Head Production Limited |
| record_format | Article |
| series | Sokoto Journal of Medical Laboratory Science |
| spelling | doaj-art-d4af49ade03f4c858f98e52dc754b3ea2025-08-20T03:42:35ZengHammer Head Production LimitedSokoto Journal of Medical Laboratory Science2536-71532020-12-0154114Comparative efficacy between Livolin forte® and Ocimum gratissimum on CCl 4 induced Liver damage in Wistar albino Rats.Ighodaro, C.N. * , Ebo, O.E. and Agoreyo, F.In recent years, the incidence of liver disease has remained an important public health problem worldwide despite global attention to eradicate it. Both Livolin forte® (LIV) and extract of Ocimum gratissimum have been used separately as hepatoprotective agent. The aim of this study was to compare the efficacy of Livolin forte® and Ocimum gratissimum at ameliorating liver damage. Twenty-four albino Wistar rats weighing between 150-200 g were used. They were randomly distributed into six groups (6) comprising four animals in each group. Group 1 rats (normal control) received 0.3 ml/kg/day of propylene glycol, the vehicle in which LIV was dissolved, orally for 4 weeks. Group 2 (toxic) received CCl 4 , dissolved in olive oil (1:1 v/v) at 0.7 ml/kg for 7 alternating days, so as to induce liver damage. Group 3 (standard) were pre-treated as group 2 after which they received oral administration of Livolin forte® at 5.2 mg/kg for 4 consecutive weeks and Group 4, 5 and 6 were pre-treated as group 2 and thereafter received oral graded doses of the extract at 100 mg/kg, 200 mg/kg and 400 mg/kg respectively for 4 consecutive weeks. The result showed that Livolin forte® group, pretreated with CCl 4 (Group 3) has a lower level of Serum Bilirubin, AST, ALT and ALP when compared with the extract of Ocimum gratissimum treated groups (Group 4, 5 and 6). However, this was statistically significant (p>0.05). In conclusion, Livolin forte® was better as a curative agent than Ocimum gratissimum extract in rats. It showed a higher level of efficacy on CCl 4 induced liver damage. This supports the use of the drug for treating hepatic damage in humans.https://sokjmls.com.ng/index.php/SJMLS/article/view/114hepatoprotective, livolin forte®, ocimum gratissimum, carbon tetrachloride (ccl 4). |
| spellingShingle | Ighodaro, C.N. * , Ebo, O.E. and Agoreyo, F. Comparative efficacy between Livolin forte® and Ocimum gratissimum on CCl 4 induced Liver damage in Wistar albino Rats. Sokoto Journal of Medical Laboratory Science hepatoprotective, livolin forte®, ocimum gratissimum, carbon tetrachloride (ccl 4). |
| title | Comparative efficacy between Livolin forte® and Ocimum gratissimum on CCl 4 induced Liver damage in Wistar albino Rats. |
| title_full | Comparative efficacy between Livolin forte® and Ocimum gratissimum on CCl 4 induced Liver damage in Wistar albino Rats. |
| title_fullStr | Comparative efficacy between Livolin forte® and Ocimum gratissimum on CCl 4 induced Liver damage in Wistar albino Rats. |
| title_full_unstemmed | Comparative efficacy between Livolin forte® and Ocimum gratissimum on CCl 4 induced Liver damage in Wistar albino Rats. |
| title_short | Comparative efficacy between Livolin forte® and Ocimum gratissimum on CCl 4 induced Liver damage in Wistar albino Rats. |
| title_sort | comparative efficacy between livolin forte r and ocimum gratissimum on ccl 4 induced liver damage in wistar albino rats |
| topic | hepatoprotective, livolin forte®, ocimum gratissimum, carbon tetrachloride (ccl 4). |
| url | https://sokjmls.com.ng/index.php/SJMLS/article/view/114 |
| work_keys_str_mv | AT ighodarocnebooeandagoreyof comparativeefficacybetweenlivolinforteandocimumgratissimumonccl4inducedliverdamageinwistaralbinorats |