Plasticity of the Primary Motor Cortex in Patients with Primary Brain Tumors
There are two neuron-level mechanisms proposed to underlie neural plasticity: recruiting neurons nearby to support the lost function (ipsilesional plasticity) and uncovering latent pathways that can assume the function that was lost (contralesional plasticity). While both patterns have been demonstr...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2020/3648517 |
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| author | Nathan W. Kong William R. Gibb Suvarna Badhe Benjamin P. Liu Matthew C. Tate |
| author_facet | Nathan W. Kong William R. Gibb Suvarna Badhe Benjamin P. Liu Matthew C. Tate |
| author_sort | Nathan W. Kong |
| collection | DOAJ |
| description | There are two neuron-level mechanisms proposed to underlie neural plasticity: recruiting neurons nearby to support the lost function (ipsilesional plasticity) and uncovering latent pathways that can assume the function that was lost (contralesional plasticity). While both patterns have been demonstrated in patient groups following injury, the specific mechanisms underlying each mode of plasticity are poorly understood. In a retrospective case series of 13 patients, we utilize a novel paradigm that analyzes serial fMRI scans in patients harboring intrinsic brain tumors that vary in location and growth kinetics to better understand the mechanisms underlying these two modes of plasticity in the human primary motor cortex. Twelve patients in our series had some degree of primary motor cortex plasticity, an area previously thought to have limited plasticity. Patients harboring smaller lesions with slower growth kinetics and increasing distance from the primary motor region demonstrated recruitment of ipsilateral motor regions. Conversely, larger, faster-growing lesions in close proximity to the primary motor region were associated with activation of the contralesional primary motor cortex, along with increased activation of the supplementary motor area. These data increase our understanding of the adaptive abilities of the brain and may lead to improved treatment strategies for those suffering from motor loss secondary to brain injuries. |
| format | Article |
| id | doaj-art-d4ad440e54374476b15f6a241bde8b29 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-d4ad440e54374476b15f6a241bde8b292025-02-03T01:05:22ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/36485173648517Plasticity of the Primary Motor Cortex in Patients with Primary Brain TumorsNathan W. Kong0William R. Gibb1Suvarna Badhe2Benjamin P. Liu3Matthew C. Tate4Department of Medicine, University of Chicago, Pritzker School of Medicine, Chicago, IL, USADepartment of Emergency Medicine, Stanford University, Palo Alto, CA, USADepartment of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USADepartment of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USADepartments of Neurological Surgery and Neurology, Northwestern University Feinberg School of Medicine, Chicago IL, USAThere are two neuron-level mechanisms proposed to underlie neural plasticity: recruiting neurons nearby to support the lost function (ipsilesional plasticity) and uncovering latent pathways that can assume the function that was lost (contralesional plasticity). While both patterns have been demonstrated in patient groups following injury, the specific mechanisms underlying each mode of plasticity are poorly understood. In a retrospective case series of 13 patients, we utilize a novel paradigm that analyzes serial fMRI scans in patients harboring intrinsic brain tumors that vary in location and growth kinetics to better understand the mechanisms underlying these two modes of plasticity in the human primary motor cortex. Twelve patients in our series had some degree of primary motor cortex plasticity, an area previously thought to have limited plasticity. Patients harboring smaller lesions with slower growth kinetics and increasing distance from the primary motor region demonstrated recruitment of ipsilateral motor regions. Conversely, larger, faster-growing lesions in close proximity to the primary motor region were associated with activation of the contralesional primary motor cortex, along with increased activation of the supplementary motor area. These data increase our understanding of the adaptive abilities of the brain and may lead to improved treatment strategies for those suffering from motor loss secondary to brain injuries.http://dx.doi.org/10.1155/2020/3648517 |
| spellingShingle | Nathan W. Kong William R. Gibb Suvarna Badhe Benjamin P. Liu Matthew C. Tate Plasticity of the Primary Motor Cortex in Patients with Primary Brain Tumors Neural Plasticity |
| title | Plasticity of the Primary Motor Cortex in Patients with Primary Brain Tumors |
| title_full | Plasticity of the Primary Motor Cortex in Patients with Primary Brain Tumors |
| title_fullStr | Plasticity of the Primary Motor Cortex in Patients with Primary Brain Tumors |
| title_full_unstemmed | Plasticity of the Primary Motor Cortex in Patients with Primary Brain Tumors |
| title_short | Plasticity of the Primary Motor Cortex in Patients with Primary Brain Tumors |
| title_sort | plasticity of the primary motor cortex in patients with primary brain tumors |
| url | http://dx.doi.org/10.1155/2020/3648517 |
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