Gastrointestinal stromal tumor – An overview
Gastrointestinal stromal tumors (GISTs) are rare tumors but are most common mesenchymal tumors of the digestive tract. They are commonly seen in the stomach (60%) and small intestine (30%). GISTs are likely derived from the interstitial cells of Cajal or their stem cell precursors. They are best cha...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2020-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
| Subjects: | |
| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2020;volume=41;issue=6;spage=809;epage=818;aulast=Ramaswamy |
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| _version_ | 1850188544066191360 |
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| author | Anant Ramaswamy Vikram Chaudhari Prabhat Bhargava Manish Bhandare Rajiv Kumar Shailesh V Shrikhande Vikas Ostwal |
| author_facet | Anant Ramaswamy Vikram Chaudhari Prabhat Bhargava Manish Bhandare Rajiv Kumar Shailesh V Shrikhande Vikas Ostwal |
| author_sort | Anant Ramaswamy |
| collection | DOAJ |
| description | Gastrointestinal stromal tumors (GISTs) are rare tumors but are most common mesenchymal tumors of the digestive tract. They are commonly seen in the stomach (60%) and small intestine (30%). GISTs are likely derived from the interstitial cells of Cajal or their stem cell precursors. They are best characterized by computerized tomography and have a specific staining pattern on immunohistochemistry, i.e., C-Kit and DOG-1. The treatment of GIST is based on the risk assessment for relapse, and patients with localized GIST require resection with or without adjuvant imatinib mesylate (IM). Advanced unresectable tumors are usually treated with IM, with a number of further options available for patients post progression on IM. There is an increasing emphasis on identifying C-Kit and platelet-derived growth factor receptor alpha mutations in all patients with GIST, as these are driver mutations with current and future therapeutic implications. |
| format | Article |
| id | doaj-art-d4a728e0007149b1a79ea5aa6b6c05a8 |
| institution | OA Journals |
| issn | 0971-5851 0975-2129 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-d4a728e0007149b1a79ea5aa6b6c05a82025-08-20T02:15:51ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-21292020-01-0141680981810.4103/ijmpo.ijmpo_45_20Gastrointestinal stromal tumor – An overviewAnant RamaswamyVikram ChaudhariPrabhat BhargavaManish BhandareRajiv KumarShailesh V ShrikhandeVikas OstwalGastrointestinal stromal tumors (GISTs) are rare tumors but are most common mesenchymal tumors of the digestive tract. They are commonly seen in the stomach (60%) and small intestine (30%). GISTs are likely derived from the interstitial cells of Cajal or their stem cell precursors. They are best characterized by computerized tomography and have a specific staining pattern on immunohistochemistry, i.e., C-Kit and DOG-1. The treatment of GIST is based on the risk assessment for relapse, and patients with localized GIST require resection with or without adjuvant imatinib mesylate (IM). Advanced unresectable tumors are usually treated with IM, with a number of further options available for patients post progression on IM. There is an increasing emphasis on identifying C-Kit and platelet-derived growth factor receptor alpha mutations in all patients with GIST, as these are driver mutations with current and future therapeutic implications.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2020;volume=41;issue=6;spage=809;epage=818;aulast=Ramaswamygastrointestinal stromal tumorindian dataoverview |
| spellingShingle | Anant Ramaswamy Vikram Chaudhari Prabhat Bhargava Manish Bhandare Rajiv Kumar Shailesh V Shrikhande Vikas Ostwal Gastrointestinal stromal tumor – An overview Indian Journal of Medical and Paediatric Oncology gastrointestinal stromal tumor indian data overview |
| title | Gastrointestinal stromal tumor – An overview |
| title_full | Gastrointestinal stromal tumor – An overview |
| title_fullStr | Gastrointestinal stromal tumor – An overview |
| title_full_unstemmed | Gastrointestinal stromal tumor – An overview |
| title_short | Gastrointestinal stromal tumor – An overview |
| title_sort | gastrointestinal stromal tumor an overview |
| topic | gastrointestinal stromal tumor indian data overview |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2020;volume=41;issue=6;spage=809;epage=818;aulast=Ramaswamy |
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