Role of precision medicine in obstructive sleep apnoea
Obstructive sleep apnoea is a substantial clinical and public health problem because it contributes to harmful effects on quality of life, daytime symptoms, road traffic incidents, and cardiometabolic disease. Increasingly, obstructive sleep apnoea is recognised as a heterogeneous disease, and patie...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-10-01
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| Series: | BMJ Medicine |
| Online Access: | https://bmjmedicine.bmj.com/content/2/1/e000218.full |
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| author | Najib Ayas Yu Liu Ali Abdul Ghafoor Mohammadreza Hajipour |
| author_facet | Najib Ayas Yu Liu Ali Abdul Ghafoor Mohammadreza Hajipour |
| author_sort | Najib Ayas |
| collection | DOAJ |
| description | Obstructive sleep apnoea is a substantial clinical and public health problem because it contributes to harmful effects on quality of life, daytime symptoms, road traffic incidents, and cardiometabolic disease. Increasingly, obstructive sleep apnoea is recognised as a heterogeneous disease, and patients have varied susceptibility to long term complications and different responses to treatment. This narrative review summarises the current knowledge of precision medicine in obstructive sleep apnoea, particularly the role of symptom clusters, polysomnogram phenotypes, physiological endotypes, and circulating biomarkers in defining subtypes. In the near future, the prognostic accuracy of these measures in predicting long term complications in obstructive sleep apnoea will likely be improved, together with better matching of treatments to disease subtypes. |
| format | Article |
| id | doaj-art-d4a1bfe69c944262b4a5ac768804f8ca |
| institution | Kabale University |
| issn | 2754-0413 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Medicine |
| spelling | doaj-art-d4a1bfe69c944262b4a5ac768804f8ca2025-08-20T03:49:40ZengBMJ Publishing GroupBMJ Medicine2754-04132023-10-012110.1136/bmjmed-2022-000218Role of precision medicine in obstructive sleep apnoeaNajib Ayas0Yu Liu1Ali Abdul Ghafoor2Mohammadreza Hajipour34 Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada1 State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Beijing, ChinaDepartment of Medicine, University of British Columbia Faculty of Medicine, Vancouver, BC, CanadaDivision of Experimental Medicine, Department of Medicine, University of British Columbia Faculty of Medicine, Vancouver, BC, CanadaObstructive sleep apnoea is a substantial clinical and public health problem because it contributes to harmful effects on quality of life, daytime symptoms, road traffic incidents, and cardiometabolic disease. Increasingly, obstructive sleep apnoea is recognised as a heterogeneous disease, and patients have varied susceptibility to long term complications and different responses to treatment. This narrative review summarises the current knowledge of precision medicine in obstructive sleep apnoea, particularly the role of symptom clusters, polysomnogram phenotypes, physiological endotypes, and circulating biomarkers in defining subtypes. In the near future, the prognostic accuracy of these measures in predicting long term complications in obstructive sleep apnoea will likely be improved, together with better matching of treatments to disease subtypes.https://bmjmedicine.bmj.com/content/2/1/e000218.full |
| spellingShingle | Najib Ayas Yu Liu Ali Abdul Ghafoor Mohammadreza Hajipour Role of precision medicine in obstructive sleep apnoea BMJ Medicine |
| title | Role of precision medicine in obstructive sleep apnoea |
| title_full | Role of precision medicine in obstructive sleep apnoea |
| title_fullStr | Role of precision medicine in obstructive sleep apnoea |
| title_full_unstemmed | Role of precision medicine in obstructive sleep apnoea |
| title_short | Role of precision medicine in obstructive sleep apnoea |
| title_sort | role of precision medicine in obstructive sleep apnoea |
| url | https://bmjmedicine.bmj.com/content/2/1/e000218.full |
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