Recent Insights into Antibiotic Resistance in Helicobacter pylori Eradication
Antibiotics have been useful in the treatment of H. pylori-related benign and malignant gastroduodenal diseases. However, emergence of antibiotic resistance often decreases the eradication rates of H. pylori infections. Many factors have been implicated as causes of treatment failure, but the main a...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/723183 |
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| author | Wenming Wu Yunsheng Yang Gang Sun |
| author_facet | Wenming Wu Yunsheng Yang Gang Sun |
| author_sort | Wenming Wu |
| collection | DOAJ |
| description | Antibiotics have been useful in the treatment of H. pylori-related benign and malignant gastroduodenal diseases. However, emergence of antibiotic resistance often decreases the eradication rates of H. pylori infections. Many factors have been implicated as causes of treatment failure, but the main antibiotic resistance mechanisms described to date are due to point mutations on the bacterial chromosome, a consequence of a significantly phenotypic variation in H. pylori. The prevalence of antibiotic (e.g., clarithromycin, metronidazole, tetracycline, amoxicillin, and furazolidone) resistance varies among different countries; it appears to be partly determined by geographical factors. Since the worldwide increase in the rate of antibiotic resistance represents a problem of relevance, some studies have been performed in order to identify highly active and well-tolerated anti-H. pylori therapies including sequential, concomitant quadruple, hybrid, and quadruple therapy. These represent a promising alternatives in the effort to overcome the problem of resistance. The aim of this paper is to review the current status of antibiotic resistance in H. pylori eradication, highlighting the evolutionary processes in detail at alternative approaches to treatment in the past decade. The underlying resistance mechanisms will be also followed. |
| format | Article |
| id | doaj-art-d49e6fee6df84dc0bcf4088c2a6ed1eb |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-d49e6fee6df84dc0bcf4088c2a6ed1eb2025-02-03T06:06:12ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/723183723183Recent Insights into Antibiotic Resistance in Helicobacter pylori EradicationWenming Wu0Yunsheng Yang1Gang Sun2Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, ChinaDepartment of Gastroenterology and Hepatology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, ChinaDepartment of Gastroenterology and Hepatology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, ChinaAntibiotics have been useful in the treatment of H. pylori-related benign and malignant gastroduodenal diseases. However, emergence of antibiotic resistance often decreases the eradication rates of H. pylori infections. Many factors have been implicated as causes of treatment failure, but the main antibiotic resistance mechanisms described to date are due to point mutations on the bacterial chromosome, a consequence of a significantly phenotypic variation in H. pylori. The prevalence of antibiotic (e.g., clarithromycin, metronidazole, tetracycline, amoxicillin, and furazolidone) resistance varies among different countries; it appears to be partly determined by geographical factors. Since the worldwide increase in the rate of antibiotic resistance represents a problem of relevance, some studies have been performed in order to identify highly active and well-tolerated anti-H. pylori therapies including sequential, concomitant quadruple, hybrid, and quadruple therapy. These represent a promising alternatives in the effort to overcome the problem of resistance. The aim of this paper is to review the current status of antibiotic resistance in H. pylori eradication, highlighting the evolutionary processes in detail at alternative approaches to treatment in the past decade. The underlying resistance mechanisms will be also followed.http://dx.doi.org/10.1155/2012/723183 |
| spellingShingle | Wenming Wu Yunsheng Yang Gang Sun Recent Insights into Antibiotic Resistance in Helicobacter pylori Eradication Gastroenterology Research and Practice |
| title | Recent Insights into Antibiotic Resistance in Helicobacter pylori Eradication |
| title_full | Recent Insights into Antibiotic Resistance in Helicobacter pylori Eradication |
| title_fullStr | Recent Insights into Antibiotic Resistance in Helicobacter pylori Eradication |
| title_full_unstemmed | Recent Insights into Antibiotic Resistance in Helicobacter pylori Eradication |
| title_short | Recent Insights into Antibiotic Resistance in Helicobacter pylori Eradication |
| title_sort | recent insights into antibiotic resistance in helicobacter pylori eradication |
| url | http://dx.doi.org/10.1155/2012/723183 |
| work_keys_str_mv | AT wenmingwu recentinsightsintoantibioticresistanceinhelicobacterpylorieradication AT yunshengyang recentinsightsintoantibioticresistanceinhelicobacterpylorieradication AT gangsun recentinsightsintoantibioticresistanceinhelicobacterpylorieradication |