NLRP3 inflammasome-modulated angiogenic function of EPC via PI3K/ Akt/mTOR pathway in diabetic myocardial infarction

NLRP3 inflammasome-modulated angiogenic function of EPC via PI3K/ Akt/mTOR pathway in diabetic myocardial infarction

Abstract Background Inflammatory diseases impair the reparative properties of endothelial progenitor cells (EPC); however, the involvement of diabetes in EPC dysfunction associated with myocardial infarction (MI) remains unknown. Methods A model was established combining high-fat diet (HFD)/streptoz...

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Main Authors: Jia-Peng Li, Shu Qiu, Guang-Jie Tai, Yi-Ming Liu, Wei Wei, Meng-Meng Fu, Pan-Qi Fang, Joseph Nicolao Otieno, Tungalag Battulga, Xiao-Xue Li, Ming Xu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cardiovascular Diabetology
Subjects:
Myocardial infarction
Diabetes
Endothelial progenitor cell
NLRP3 inflammasome
Angiogenesis
Online Access:https://doi.org/10.1186/s12933-024-02541-3
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