The association between phenotypes of polycystic ovary syndrome and metabolic dysfunction-associated fatty liver disease
IntroductionPolycystic ovary syndrome (PCOS) is associated with an increased risk of non-alcoholic fatty liver disease (NAFLD). With the introduction of the new definition of metabolic dysfunction-associated fatty liver disease (MAFLD), there has been a lack of studies investigating the prevalence a...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-08-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1480528/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849343262734680064 |
|---|---|
| author | So-hyeon Hong Yeon-Ah Sung Young Sun Hong Do Kyeong Song Hyein Jung Kyungah Jeong Hyewon Chung Hyejin Lee |
| author_facet | So-hyeon Hong Yeon-Ah Sung Young Sun Hong Do Kyeong Song Hyein Jung Kyungah Jeong Hyewon Chung Hyejin Lee |
| author_sort | So-hyeon Hong |
| collection | DOAJ |
| description | IntroductionPolycystic ovary syndrome (PCOS) is associated with an increased risk of non-alcoholic fatty liver disease (NAFLD). With the introduction of the new definition of metabolic dysfunction-associated fatty liver disease (MAFLD), there has been a lack of studies investigating the prevalence and clinical characteristics of PCOS and its phenotypes, including hyperandrogenism (HA), oligoanovulation (OA), and polycystic ovarian morphology (PCO) in association with MAFLD. The aim of this study is to explore MAFLD prevalence in young women with PCOS and determine the independent impact of PCOS phenotypes on MAFLD.MethodsThis cross-sectional study included 1,422 women with PCOS diagnosed using the Rotterdam criteria, the presence of at least two of three diagnostic criteria: 1) hyperandrogenism (HA), 2) oligoanovulation (OA), and 3) polycystic ovary morphology (PCO).ResultsAmong women with PCOS, 31.2% had NAFLD, and 65.1% of them were diagnosed with MAFLD. In PCOS phenotypes, MAFLD prevalence was 25.1% for HA+OA+PCO, 27.6% for HA+OA, 8.8% for HA+PCO, and 13.0% for OA+PCO. Women with PCOS and HA+OA+PCO had higher odds of MAFLD (OR [95% CI] of 1.47 [1.04–2.09]), as did those with HA+OA (1.87 [1.18–2.96]), after adjusting for demographic and clinical factors. However, the association between women with PCOS and HA+PCO and MAFLD was not statistically significant (0.51 [0.21–1.24]).DiscussionIn women with PCOS, both HA+OA+PCO and HA+OA phenotypes were independently associated with MAFLD. HA and OA may contribute independently to the higher prevalence of MAFLD in these individuals. |
| format | Article |
| id | doaj-art-d4867dc9e2a84cb4bfd85d7af5db83bc |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-d4867dc9e2a84cb4bfd85d7af5db83bc2025-08-20T03:43:02ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-08-011610.3389/fendo.2025.14805281480528The association between phenotypes of polycystic ovary syndrome and metabolic dysfunction-associated fatty liver diseaseSo-hyeon Hong0Yeon-Ah Sung1Young Sun Hong2Do Kyeong Song3Hyein Jung4Kyungah Jeong5Hyewon Chung6Hyejin Lee7Division of Endocrinology and Metabolism, Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Republic of KoreaDepartment of Obstetrics and Gynecology, Ewha Womans University College of Medicine, Seoul, Republic of KoreaDepartment of Obstetrics and Gynecology, Ewha Womans University College of Medicine, Seoul, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Republic of KoreaIntroductionPolycystic ovary syndrome (PCOS) is associated with an increased risk of non-alcoholic fatty liver disease (NAFLD). With the introduction of the new definition of metabolic dysfunction-associated fatty liver disease (MAFLD), there has been a lack of studies investigating the prevalence and clinical characteristics of PCOS and its phenotypes, including hyperandrogenism (HA), oligoanovulation (OA), and polycystic ovarian morphology (PCO) in association with MAFLD. The aim of this study is to explore MAFLD prevalence in young women with PCOS and determine the independent impact of PCOS phenotypes on MAFLD.MethodsThis cross-sectional study included 1,422 women with PCOS diagnosed using the Rotterdam criteria, the presence of at least two of three diagnostic criteria: 1) hyperandrogenism (HA), 2) oligoanovulation (OA), and 3) polycystic ovary morphology (PCO).ResultsAmong women with PCOS, 31.2% had NAFLD, and 65.1% of them were diagnosed with MAFLD. In PCOS phenotypes, MAFLD prevalence was 25.1% for HA+OA+PCO, 27.6% for HA+OA, 8.8% for HA+PCO, and 13.0% for OA+PCO. Women with PCOS and HA+OA+PCO had higher odds of MAFLD (OR [95% CI] of 1.47 [1.04–2.09]), as did those with HA+OA (1.87 [1.18–2.96]), after adjusting for demographic and clinical factors. However, the association between women with PCOS and HA+PCO and MAFLD was not statistically significant (0.51 [0.21–1.24]).DiscussionIn women with PCOS, both HA+OA+PCO and HA+OA phenotypes were independently associated with MAFLD. HA and OA may contribute independently to the higher prevalence of MAFLD in these individuals.https://www.frontiersin.org/articles/10.3389/fendo.2025.1480528/fullpolycystic ovary syndromemetabolic-associated fatty liver diseasehyperandrogenismoligomenorrheapolycystic ovary morphology |
| spellingShingle | So-hyeon Hong Yeon-Ah Sung Young Sun Hong Do Kyeong Song Hyein Jung Kyungah Jeong Hyewon Chung Hyejin Lee The association between phenotypes of polycystic ovary syndrome and metabolic dysfunction-associated fatty liver disease Frontiers in Endocrinology polycystic ovary syndrome metabolic-associated fatty liver disease hyperandrogenism oligomenorrhea polycystic ovary morphology |
| title | The association between phenotypes of polycystic ovary syndrome and metabolic dysfunction-associated fatty liver disease |
| title_full | The association between phenotypes of polycystic ovary syndrome and metabolic dysfunction-associated fatty liver disease |
| title_fullStr | The association between phenotypes of polycystic ovary syndrome and metabolic dysfunction-associated fatty liver disease |
| title_full_unstemmed | The association between phenotypes of polycystic ovary syndrome and metabolic dysfunction-associated fatty liver disease |
| title_short | The association between phenotypes of polycystic ovary syndrome and metabolic dysfunction-associated fatty liver disease |
| title_sort | association between phenotypes of polycystic ovary syndrome and metabolic dysfunction associated fatty liver disease |
| topic | polycystic ovary syndrome metabolic-associated fatty liver disease hyperandrogenism oligomenorrhea polycystic ovary morphology |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1480528/full |
| work_keys_str_mv | AT sohyeonhong theassociationbetweenphenotypesofpolycysticovarysyndromeandmetabolicdysfunctionassociatedfattyliverdisease AT yeonahsung theassociationbetweenphenotypesofpolycysticovarysyndromeandmetabolicdysfunctionassociatedfattyliverdisease AT youngsunhong theassociationbetweenphenotypesofpolycysticovarysyndromeandmetabolicdysfunctionassociatedfattyliverdisease AT dokyeongsong theassociationbetweenphenotypesofpolycysticovarysyndromeandmetabolicdysfunctionassociatedfattyliverdisease AT hyeinjung theassociationbetweenphenotypesofpolycysticovarysyndromeandmetabolicdysfunctionassociatedfattyliverdisease AT kyungahjeong theassociationbetweenphenotypesofpolycysticovarysyndromeandmetabolicdysfunctionassociatedfattyliverdisease AT hyewonchung theassociationbetweenphenotypesofpolycysticovarysyndromeandmetabolicdysfunctionassociatedfattyliverdisease AT hyejinlee theassociationbetweenphenotypesofpolycysticovarysyndromeandmetabolicdysfunctionassociatedfattyliverdisease AT sohyeonhong associationbetweenphenotypesofpolycysticovarysyndromeandmetabolicdysfunctionassociatedfattyliverdisease AT yeonahsung associationbetweenphenotypesofpolycysticovarysyndromeandmetabolicdysfunctionassociatedfattyliverdisease AT youngsunhong associationbetweenphenotypesofpolycysticovarysyndromeandmetabolicdysfunctionassociatedfattyliverdisease AT dokyeongsong associationbetweenphenotypesofpolycysticovarysyndromeandmetabolicdysfunctionassociatedfattyliverdisease AT hyeinjung associationbetweenphenotypesofpolycysticovarysyndromeandmetabolicdysfunctionassociatedfattyliverdisease AT kyungahjeong associationbetweenphenotypesofpolycysticovarysyndromeandmetabolicdysfunctionassociatedfattyliverdisease AT hyewonchung associationbetweenphenotypesofpolycysticovarysyndromeandmetabolicdysfunctionassociatedfattyliverdisease AT hyejinlee associationbetweenphenotypesofpolycysticovarysyndromeandmetabolicdysfunctionassociatedfattyliverdisease |