Spatial metabolomics in mental disorders and traditional Chinese medicine: a review
Spatial metabolomics is an emerging technology that integrates mass spectrometry imaging (MSI) with metabolomics, offering a novel visual perspective for traditional metabolomics analysis. This technology enables in-depth analysis in three dimensions: qualitative, quantitative, and localization of m...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1449639/full |
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| author | Chaofang Lei Jiaxu Chen Zhigang Chen Chongyang Ma Xudong Chen Xiongxing Sun Xukun Tang Jun Deng Shiliang Wang Junlin Jiang Dahua Wu Le Xie |
| author_facet | Chaofang Lei Jiaxu Chen Zhigang Chen Chongyang Ma Xudong Chen Xiongxing Sun Xukun Tang Jun Deng Shiliang Wang Junlin Jiang Dahua Wu Le Xie |
| author_sort | Chaofang Lei |
| collection | DOAJ |
| description | Spatial metabolomics is an emerging technology that integrates mass spectrometry imaging (MSI) with metabolomics, offering a novel visual perspective for traditional metabolomics analysis. This technology enables in-depth analysis in three dimensions: qualitative, quantitative, and localization of metabolites. Spatial metabolomics precisely reflects the characteristics of metabolic network changes in metabolites within entire tissues or specific micro-regions. It provides a detailed understanding of the pharmacodynamic material basis and mechanisms of action. These capabilities suggest that spatial metabolomics can offer significant technical support for studying the complex pathophysiology of mental disorders. Although the mechanisms underlying mental disorders have been reviewed multiple times, this paper provides a comprehensive comparison between traditional metabolomics and spatial metabolomics. It also summarizes the latest progress and challenges of applying spatial metabolomics to the study of mental disorders and traditional Chinese medicine. |
| format | Article |
| id | doaj-art-d485bd2c40d44201a85b9088c6e16e5d |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-d485bd2c40d44201a85b9088c6e16e5d2025-01-31T06:40:08ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011610.3389/fphar.2025.14496391449639Spatial metabolomics in mental disorders and traditional Chinese medicine: a reviewChaofang Lei0Jiaxu Chen1Zhigang Chen2Chongyang Ma3Xudong Chen4Xiongxing Sun5Xukun Tang6Jun Deng7Shiliang Wang8Junlin Jiang9Dahua Wu10Le Xie11Department of Neurology, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Neurology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Neurology, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, ChinaDepartment of Neurology, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, ChinaDepartment of Neurology, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, ChinaDepartment of Neurology, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, ChinaDepartment of Neurology, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, ChinaDepartment of Neurology, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, ChinaDepartment of Neurology, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, ChinaSpatial metabolomics is an emerging technology that integrates mass spectrometry imaging (MSI) with metabolomics, offering a novel visual perspective for traditional metabolomics analysis. This technology enables in-depth analysis in three dimensions: qualitative, quantitative, and localization of metabolites. Spatial metabolomics precisely reflects the characteristics of metabolic network changes in metabolites within entire tissues or specific micro-regions. It provides a detailed understanding of the pharmacodynamic material basis and mechanisms of action. These capabilities suggest that spatial metabolomics can offer significant technical support for studying the complex pathophysiology of mental disorders. Although the mechanisms underlying mental disorders have been reviewed multiple times, this paper provides a comprehensive comparison between traditional metabolomics and spatial metabolomics. It also summarizes the latest progress and challenges of applying spatial metabolomics to the study of mental disorders and traditional Chinese medicine.https://www.frontiersin.org/articles/10.3389/fphar.2025.1449639/fullmental disorderstraditional Chinese medicinespatial metabolomicsmass spectrometry imagingDESI-MSIMALDI-MSI |
| spellingShingle | Chaofang Lei Jiaxu Chen Zhigang Chen Chongyang Ma Xudong Chen Xiongxing Sun Xukun Tang Jun Deng Shiliang Wang Junlin Jiang Dahua Wu Le Xie Spatial metabolomics in mental disorders and traditional Chinese medicine: a review Frontiers in Pharmacology mental disorders traditional Chinese medicine spatial metabolomics mass spectrometry imaging DESI-MSI MALDI-MSI |
| title | Spatial metabolomics in mental disorders and traditional Chinese medicine: a review |
| title_full | Spatial metabolomics in mental disorders and traditional Chinese medicine: a review |
| title_fullStr | Spatial metabolomics in mental disorders and traditional Chinese medicine: a review |
| title_full_unstemmed | Spatial metabolomics in mental disorders and traditional Chinese medicine: a review |
| title_short | Spatial metabolomics in mental disorders and traditional Chinese medicine: a review |
| title_sort | spatial metabolomics in mental disorders and traditional chinese medicine a review |
| topic | mental disorders traditional Chinese medicine spatial metabolomics mass spectrometry imaging DESI-MSI MALDI-MSI |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1449639/full |
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