Spatial metabolomics in mental disorders and traditional Chinese medicine: a review

Spatial metabolomics is an emerging technology that integrates mass spectrometry imaging (MSI) with metabolomics, offering a novel visual perspective for traditional metabolomics analysis. This technology enables in-depth analysis in three dimensions: qualitative, quantitative, and localization of m...

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Main Authors: Chaofang Lei, Jiaxu Chen, Zhigang Chen, Chongyang Ma, Xudong Chen, Xiongxing Sun, Xukun Tang, Jun Deng, Shiliang Wang, Junlin Jiang, Dahua Wu, Le Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1449639/full
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author Chaofang Lei
Jiaxu Chen
Zhigang Chen
Chongyang Ma
Xudong Chen
Xiongxing Sun
Xukun Tang
Jun Deng
Shiliang Wang
Junlin Jiang
Dahua Wu
Le Xie
author_facet Chaofang Lei
Jiaxu Chen
Zhigang Chen
Chongyang Ma
Xudong Chen
Xiongxing Sun
Xukun Tang
Jun Deng
Shiliang Wang
Junlin Jiang
Dahua Wu
Le Xie
author_sort Chaofang Lei
collection DOAJ
description Spatial metabolomics is an emerging technology that integrates mass spectrometry imaging (MSI) with metabolomics, offering a novel visual perspective for traditional metabolomics analysis. This technology enables in-depth analysis in three dimensions: qualitative, quantitative, and localization of metabolites. Spatial metabolomics precisely reflects the characteristics of metabolic network changes in metabolites within entire tissues or specific micro-regions. It provides a detailed understanding of the pharmacodynamic material basis and mechanisms of action. These capabilities suggest that spatial metabolomics can offer significant technical support for studying the complex pathophysiology of mental disorders. Although the mechanisms underlying mental disorders have been reviewed multiple times, this paper provides a comprehensive comparison between traditional metabolomics and spatial metabolomics. It also summarizes the latest progress and challenges of applying spatial metabolomics to the study of mental disorders and traditional Chinese medicine.
format Article
id doaj-art-d485bd2c40d44201a85b9088c6e16e5d
institution Kabale University
issn 1663-9812
language English
publishDate 2025-01-01
publisher Frontiers Media S.A.
record_format Article
series Frontiers in Pharmacology
spelling doaj-art-d485bd2c40d44201a85b9088c6e16e5d2025-01-31T06:40:08ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011610.3389/fphar.2025.14496391449639Spatial metabolomics in mental disorders and traditional Chinese medicine: a reviewChaofang Lei0Jiaxu Chen1Zhigang Chen2Chongyang Ma3Xudong Chen4Xiongxing Sun5Xukun Tang6Jun Deng7Shiliang Wang8Junlin Jiang9Dahua Wu10Le Xie11Department of Neurology, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Neurology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Neurology, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, ChinaDepartment of Neurology, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, ChinaDepartment of Neurology, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, ChinaDepartment of Neurology, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, ChinaDepartment of Neurology, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, ChinaDepartment of Neurology, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, ChinaDepartment of Neurology, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, ChinaSpatial metabolomics is an emerging technology that integrates mass spectrometry imaging (MSI) with metabolomics, offering a novel visual perspective for traditional metabolomics analysis. This technology enables in-depth analysis in three dimensions: qualitative, quantitative, and localization of metabolites. Spatial metabolomics precisely reflects the characteristics of metabolic network changes in metabolites within entire tissues or specific micro-regions. It provides a detailed understanding of the pharmacodynamic material basis and mechanisms of action. These capabilities suggest that spatial metabolomics can offer significant technical support for studying the complex pathophysiology of mental disorders. Although the mechanisms underlying mental disorders have been reviewed multiple times, this paper provides a comprehensive comparison between traditional metabolomics and spatial metabolomics. It also summarizes the latest progress and challenges of applying spatial metabolomics to the study of mental disorders and traditional Chinese medicine.https://www.frontiersin.org/articles/10.3389/fphar.2025.1449639/fullmental disorderstraditional Chinese medicinespatial metabolomicsmass spectrometry imagingDESI-MSIMALDI-MSI
spellingShingle Chaofang Lei
Jiaxu Chen
Zhigang Chen
Chongyang Ma
Xudong Chen
Xiongxing Sun
Xukun Tang
Jun Deng
Shiliang Wang
Junlin Jiang
Dahua Wu
Le Xie
Spatial metabolomics in mental disorders and traditional Chinese medicine: a review
Frontiers in Pharmacology
mental disorders
traditional Chinese medicine
spatial metabolomics
mass spectrometry imaging
DESI-MSI
MALDI-MSI
title Spatial metabolomics in mental disorders and traditional Chinese medicine: a review
title_full Spatial metabolomics in mental disorders and traditional Chinese medicine: a review
title_fullStr Spatial metabolomics in mental disorders and traditional Chinese medicine: a review
title_full_unstemmed Spatial metabolomics in mental disorders and traditional Chinese medicine: a review
title_short Spatial metabolomics in mental disorders and traditional Chinese medicine: a review
title_sort spatial metabolomics in mental disorders and traditional chinese medicine a review
topic mental disorders
traditional Chinese medicine
spatial metabolomics
mass spectrometry imaging
DESI-MSI
MALDI-MSI
url https://www.frontiersin.org/articles/10.3389/fphar.2025.1449639/full
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