Crosstalk between polymorphic toxin-immunity systems involved in kin discrimination
ABSTRACT Bacterial genomes contain a surprisingly large number of toxin systems that are neutralized by specific cognate antitoxins or immunity factors. Their high abundance is even apparent in common Escherichia coli K12 cloning strains, which contain at least 36 toxin-antitoxin systems, while othe...
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American Society for Microbiology
2025-05-01
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| Series: | mBio |
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| Online Access: | https://journals.asm.org/doi/10.1128/mbio.00468-25 |
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| author | Michael L. Weltzer Tingting Guo Daniel Wall |
| author_facet | Michael L. Weltzer Tingting Guo Daniel Wall |
| author_sort | Michael L. Weltzer |
| collection | DOAJ |
| description | ABSTRACT Bacterial genomes contain a surprisingly large number of toxin systems that are neutralized by specific cognate antitoxins or immunity factors. Their high abundance is even apparent in common Escherichia coli K12 cloning strains, which contain at least 36 toxin-antitoxin systems, while other bacteria frequently contain more. These numbers raise two key questions: why are they so numerous, and to what extent do toxin systems interact or interfere with one another? Recently in mBio, Wang and co-workers addressed these questions in the social bacterium Myxococcus xanthus, where they investigated crosstalk between four homologous toxin-immunity loci involved in kin discrimination. Here, the type VI secretion system delivers toxins into neighboring myxobacterial cells (F. Wang, J. Luo, Z. Zhang, Y. Liu, et al., mBio e03902-24, 2025, https://doi.org/10.1128/mbio.03902-24). If the target cell is clonal and expresses a complete set of cognate immunity proteins—which are not themselves transferred—the cell is protected. However, if immunity is incomplete, the cell is poisoned. |
| format | Article |
| id | doaj-art-d48392cd629d4a5db7e55baffdd940c7 |
| institution | OA Journals |
| issn | 2150-7511 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj-art-d48392cd629d4a5db7e55baffdd940c72025-08-20T02:25:02ZengAmerican Society for MicrobiologymBio2150-75112025-05-0116510.1128/mbio.00468-25Crosstalk between polymorphic toxin-immunity systems involved in kin discriminationMichael L. Weltzer0Tingting Guo1Daniel Wall2Department of Molecular Biology, University of Wyoming, Laramie, Wyoming, USADepartment of Molecular Biology, University of Wyoming, Laramie, Wyoming, USADepartment of Molecular Biology, University of Wyoming, Laramie, Wyoming, USAABSTRACT Bacterial genomes contain a surprisingly large number of toxin systems that are neutralized by specific cognate antitoxins or immunity factors. Their high abundance is even apparent in common Escherichia coli K12 cloning strains, which contain at least 36 toxin-antitoxin systems, while other bacteria frequently contain more. These numbers raise two key questions: why are they so numerous, and to what extent do toxin systems interact or interfere with one another? Recently in mBio, Wang and co-workers addressed these questions in the social bacterium Myxococcus xanthus, where they investigated crosstalk between four homologous toxin-immunity loci involved in kin discrimination. Here, the type VI secretion system delivers toxins into neighboring myxobacterial cells (F. Wang, J. Luo, Z. Zhang, Y. Liu, et al., mBio e03902-24, 2025, https://doi.org/10.1128/mbio.03902-24). If the target cell is clonal and expresses a complete set of cognate immunity proteins—which are not themselves transferred—the cell is protected. However, if immunity is incomplete, the cell is poisoned.https://journals.asm.org/doi/10.1128/mbio.00468-25Myxococcus xanthuspolymorphic toxinstype VI secretion systemouter membrane exchangekin discriminationnoncognate immunity |
| spellingShingle | Michael L. Weltzer Tingting Guo Daniel Wall Crosstalk between polymorphic toxin-immunity systems involved in kin discrimination mBio Myxococcus xanthus polymorphic toxins type VI secretion system outer membrane exchange kin discrimination noncognate immunity |
| title | Crosstalk between polymorphic toxin-immunity systems involved in kin discrimination |
| title_full | Crosstalk between polymorphic toxin-immunity systems involved in kin discrimination |
| title_fullStr | Crosstalk between polymorphic toxin-immunity systems involved in kin discrimination |
| title_full_unstemmed | Crosstalk between polymorphic toxin-immunity systems involved in kin discrimination |
| title_short | Crosstalk between polymorphic toxin-immunity systems involved in kin discrimination |
| title_sort | crosstalk between polymorphic toxin immunity systems involved in kin discrimination |
| topic | Myxococcus xanthus polymorphic toxins type VI secretion system outer membrane exchange kin discrimination noncognate immunity |
| url | https://journals.asm.org/doi/10.1128/mbio.00468-25 |
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