Recovery time of diabetic ketoacidosis in Africa: Systematic review and meta-analysis
Background: Diabetes mellitus is a long-term metabolic disease marked by consistently elevated blood glucose levels. Diabetic ketoacidosis is the medical consequence of diabetes mellitus that has the highest attributed fatality rate. Socioeconomically differences affect how long it takes to recover...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Metabolism Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S258993682500026X |
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| author | Tadios Lidetu Simon Birhanu Addisu Simachew Asgai Tsegaamlak Kumelachew Derse Yideg Abinew Moges Tadesse Desalegn Mitiku Jemberu Chane Banchamilak Adane Tadele Kassahun Wudu Betelhem Mekonnen Desiyalew Habtamu Tamiru |
| author_facet | Tadios Lidetu Simon Birhanu Addisu Simachew Asgai Tsegaamlak Kumelachew Derse Yideg Abinew Moges Tadesse Desalegn Mitiku Jemberu Chane Banchamilak Adane Tadele Kassahun Wudu Betelhem Mekonnen Desiyalew Habtamu Tamiru |
| author_sort | Tadios Lidetu |
| collection | DOAJ |
| description | Background: Diabetes mellitus is a long-term metabolic disease marked by consistently elevated blood glucose levels. Diabetic ketoacidosis is the medical consequence of diabetes mellitus that has the highest attributed fatality rate. Socioeconomically differences affect how long it takes to recover from diabetic ketoacidosis. A few research were carried out in Africa to demonstrate how long diabetic ketoacidosis takes to recover. However, the pooled median recovery time and predictors of diabetic ketoacidosis have not been studied in Africa. Thus, determine the pooled median recovery time and predictors of diabetic ketoacidosis in Africa was the aim of this systematic review and meta-analysis. Methods: To find available publications, a number of databases were analyzed, including PubMed, Science Direct, Cochrane, Hinari, Google Scholar, grey literature, and articles from various university repository sites. Microsoft Excel version 13 was used to extract and sort the data before exporting it to STATA/MP 17.0 for analysis. The quality of each study was evaluated using the Newcastle-Ottawa Scale. A 95 percent confidence interval Der Simonian random-effects model was employed to investigate the pooled recovery time of diabetic ketoacidosis. Publication bias and heterogeneity were assessed using the Egger's test and I2. Both meta-regression and subgroup analysis were used to determine the potential source of heterogeneity. Statistical significance was defined as P-values below 0.05. Result: The pooled median recovery time for diabetic ketoacidosis in Africa was 38 h (95 percent CI: 33–43 h), according to this comprehensive review and meta-analysis. Significant heterogeneity is evident when looking at the Galbraith plot with I2 = 100 % (p < 0.001). Research conducted after 2020 revealed that diabetic ketoacidosis has a long recovery time of 40 h (95 percent CI: 3–77 h). However, research with fewer than 300 participants showed that diabetic ketoacidosis recovered more quickly: 18 h (95 percent confidence interval: 12–24 h). Conclusion: Among patients with diabetic ketoacidosis in Africa, the pooled median recovery time was lengthy. The recovery time from diabetic ketoacidosis was influenced by a number of factors, including the severity of the diabetic ketoacidosis, the delay in starting therapy, and the length of time the patient had diabetes mellitus, and elevated blood glucose levels. Diabetic ketoacidosis recovery time can be shortened by altering these factors. |
| format | Article |
| id | doaj-art-d480077499c74803bf2ba818d213664d |
| institution | OA Journals |
| issn | 2589-9368 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Metabolism Open |
| spelling | doaj-art-d480077499c74803bf2ba818d213664d2025-08-20T02:06:32ZengElsevierMetabolism Open2589-93682025-06-012610037010.1016/j.metop.2025.100370Recovery time of diabetic ketoacidosis in Africa: Systematic review and meta-analysisTadios Lidetu0Simon Birhanu1Addisu Simachew Asgai2Tsegaamlak Kumelachew Derse3Yideg Abinew4Moges Tadesse5Desalegn Mitiku6Jemberu Chane7Banchamilak Adane8Tadele Kassahun Wudu9Betelhem Mekonnen10Desiyalew Habtamu Tamiru11College of Health Sciences, Debark University, Ethiopia; Corresponding author.College of Health Sciences, Debark University, EthiopiaDepartment of Nursing, College of Health Sciences, Debark University, Debark, EthiopiaDepartment of Nursing, College of Health Sciences, Debark University, Debark, EthiopiaDepartment of Nursing, College of Health Sciences, Debark University, Debark, EthiopiaDepartment of Nursing, College of Health Sciences, Debark University, Debark, EthiopiaDepartment of Nursing, College of Health Sciences, Debark University, Debark, EthiopiaDepartment of Midwifery, College of Health Sciences, Debark University, Debark, EthiopiaDepartment of Midwifery, College of Health Sciences, Debark University, Debark, EthiopiaDepartment of Statistics, College of Natural Sciences, Debark University, Debark, EthiopiaDepartment of Nursing, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, EthiopiaJSI Research and Training Institute, Inc., Addis Ababa, EthiopiaBackground: Diabetes mellitus is a long-term metabolic disease marked by consistently elevated blood glucose levels. Diabetic ketoacidosis is the medical consequence of diabetes mellitus that has the highest attributed fatality rate. Socioeconomically differences affect how long it takes to recover from diabetic ketoacidosis. A few research were carried out in Africa to demonstrate how long diabetic ketoacidosis takes to recover. However, the pooled median recovery time and predictors of diabetic ketoacidosis have not been studied in Africa. Thus, determine the pooled median recovery time and predictors of diabetic ketoacidosis in Africa was the aim of this systematic review and meta-analysis. Methods: To find available publications, a number of databases were analyzed, including PubMed, Science Direct, Cochrane, Hinari, Google Scholar, grey literature, and articles from various university repository sites. Microsoft Excel version 13 was used to extract and sort the data before exporting it to STATA/MP 17.0 for analysis. The quality of each study was evaluated using the Newcastle-Ottawa Scale. A 95 percent confidence interval Der Simonian random-effects model was employed to investigate the pooled recovery time of diabetic ketoacidosis. Publication bias and heterogeneity were assessed using the Egger's test and I2. Both meta-regression and subgroup analysis were used to determine the potential source of heterogeneity. Statistical significance was defined as P-values below 0.05. Result: The pooled median recovery time for diabetic ketoacidosis in Africa was 38 h (95 percent CI: 33–43 h), according to this comprehensive review and meta-analysis. Significant heterogeneity is evident when looking at the Galbraith plot with I2 = 100 % (p < 0.001). Research conducted after 2020 revealed that diabetic ketoacidosis has a long recovery time of 40 h (95 percent CI: 3–77 h). However, research with fewer than 300 participants showed that diabetic ketoacidosis recovered more quickly: 18 h (95 percent confidence interval: 12–24 h). Conclusion: Among patients with diabetic ketoacidosis in Africa, the pooled median recovery time was lengthy. The recovery time from diabetic ketoacidosis was influenced by a number of factors, including the severity of the diabetic ketoacidosis, the delay in starting therapy, and the length of time the patient had diabetes mellitus, and elevated blood glucose levels. Diabetic ketoacidosis recovery time can be shortened by altering these factors.http://www.sciencedirect.com/science/article/pii/S258993682500026XRecovery timeDiabetic ketoacidosisPredictorAfrica |
| spellingShingle | Tadios Lidetu Simon Birhanu Addisu Simachew Asgai Tsegaamlak Kumelachew Derse Yideg Abinew Moges Tadesse Desalegn Mitiku Jemberu Chane Banchamilak Adane Tadele Kassahun Wudu Betelhem Mekonnen Desiyalew Habtamu Tamiru Recovery time of diabetic ketoacidosis in Africa: Systematic review and meta-analysis Metabolism Open Recovery time Diabetic ketoacidosis Predictor Africa |
| title | Recovery time of diabetic ketoacidosis in Africa: Systematic review and meta-analysis |
| title_full | Recovery time of diabetic ketoacidosis in Africa: Systematic review and meta-analysis |
| title_fullStr | Recovery time of diabetic ketoacidosis in Africa: Systematic review and meta-analysis |
| title_full_unstemmed | Recovery time of diabetic ketoacidosis in Africa: Systematic review and meta-analysis |
| title_short | Recovery time of diabetic ketoacidosis in Africa: Systematic review and meta-analysis |
| title_sort | recovery time of diabetic ketoacidosis in africa systematic review and meta analysis |
| topic | Recovery time Diabetic ketoacidosis Predictor Africa |
| url | http://www.sciencedirect.com/science/article/pii/S258993682500026X |
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