A practical guide to the interpretation of PK/PD profiles of longer-acting analogue insulins. Part one: The principles of glucose clamp studies
Glucose clamp studies are used to determine pharmacokinetics (PK) and pharmacodynamics (PD) of analogue insulins. With the development of longer-acting basal analogue insulins, including glargine 300 (Gla-300) and insulin degludec (IDeg), results from numerous glucose clamp studies are readily avail...
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AOSIS
2018-07-01
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| Series: | South African Family Practice |
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| Online Access: | https://safpj.co.za/index.php/safpj/article/view/4874 |
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| author | Oppel B.W. Greeff Jacob John van Tonder Kershlin Naidu Alicia McMaster Alet van Tonder Rashem Mothilal |
| author_facet | Oppel B.W. Greeff Jacob John van Tonder Kershlin Naidu Alicia McMaster Alet van Tonder Rashem Mothilal |
| author_sort | Oppel B.W. Greeff |
| collection | DOAJ |
| description | Glucose clamp studies are used to determine pharmacokinetics (PK) and pharmacodynamics (PD) of analogue insulins. With the development of longer-acting basal analogue insulins, including glargine 300 (Gla-300) and insulin degludec (IDeg), results from numerous glucose clamp studies are readily available. However, interpreting PK/PD profiles in a scientifically sound manner can be a challenging feat. This is the first in a series of publications that will suggest practical tips for interpreting and comparing results from glucose clamp studies. Variations in the glucose clamp methodology, duration of clamp studies and glucose clamp targets influence the study design and results significantly. Selection of study populations, including healthy patients or patients with Type 1 or 2 diabetes mellitus, has important implications. The dose of study insulin should reflect that of the general treatment population, and ideally steady-state conditions should be used. During the study the plasma insulin concentration and glucose infusion rate describe the pharmacokinetics and pharmacodynamics of the study insulin. With these practical tips in mind, results of glucose clamp studies can be interpreted in a scientifically correct manner. The next article in this series will discuss the interpretation of PK/PD profiles using two newly developed longer-acting basal analogue insulins: Gla-300 and IDeg. |
| format | Article |
| id | doaj-art-d47df1cfb81a45daa864710f39bf33a9 |
| institution | DOAJ |
| issn | 2078-6190 2078-6204 |
| language | English |
| publishDate | 2018-07-01 |
| publisher | AOSIS |
| record_format | Article |
| series | South African Family Practice |
| spelling | doaj-art-d47df1cfb81a45daa864710f39bf33a92025-08-20T03:06:53ZengAOSISSouth African Family Practice2078-61902078-62042018-07-0160381210.4102/safp.v60i3.48743851A practical guide to the interpretation of PK/PD profiles of longer-acting analogue insulins. Part one: The principles of glucose clamp studiesOppel B.W. Greeff0Jacob John van Tonder1Kershlin Naidu2Alicia McMaster3Alet van Tonder4Rashem Mothilal5University of PretoriaTriclinium Clinical Development (Pty) LtdChris Hani Baragwanath Academic Hospital, University of the WitwatersrandSanofi-Aventis South Africa (Pty) LtdSanofi-Aventis South Africa (Pty) LtdSanofi-Aventis South Africa (Pty) LtdGlucose clamp studies are used to determine pharmacokinetics (PK) and pharmacodynamics (PD) of analogue insulins. With the development of longer-acting basal analogue insulins, including glargine 300 (Gla-300) and insulin degludec (IDeg), results from numerous glucose clamp studies are readily available. However, interpreting PK/PD profiles in a scientifically sound manner can be a challenging feat. This is the first in a series of publications that will suggest practical tips for interpreting and comparing results from glucose clamp studies. Variations in the glucose clamp methodology, duration of clamp studies and glucose clamp targets influence the study design and results significantly. Selection of study populations, including healthy patients or patients with Type 1 or 2 diabetes mellitus, has important implications. The dose of study insulin should reflect that of the general treatment population, and ideally steady-state conditions should be used. During the study the plasma insulin concentration and glucose infusion rate describe the pharmacokinetics and pharmacodynamics of the study insulin. With these practical tips in mind, results of glucose clamp studies can be interpreted in a scientifically correct manner. The next article in this series will discuss the interpretation of PK/PD profiles using two newly developed longer-acting basal analogue insulins: Gla-300 and IDeg.https://safpj.co.za/index.php/safpj/article/view/4874analogue insulinsglucose clamptime–action profileglucose infusion ratepharmacokinetics |
| spellingShingle | Oppel B.W. Greeff Jacob John van Tonder Kershlin Naidu Alicia McMaster Alet van Tonder Rashem Mothilal A practical guide to the interpretation of PK/PD profiles of longer-acting analogue insulins. Part one: The principles of glucose clamp studies South African Family Practice analogue insulins glucose clamp time–action profile glucose infusion rate pharmacokinetics |
| title | A practical guide to the interpretation of PK/PD profiles of longer-acting analogue insulins. Part one: The principles of glucose clamp studies |
| title_full | A practical guide to the interpretation of PK/PD profiles of longer-acting analogue insulins. Part one: The principles of glucose clamp studies |
| title_fullStr | A practical guide to the interpretation of PK/PD profiles of longer-acting analogue insulins. Part one: The principles of glucose clamp studies |
| title_full_unstemmed | A practical guide to the interpretation of PK/PD profiles of longer-acting analogue insulins. Part one: The principles of glucose clamp studies |
| title_short | A practical guide to the interpretation of PK/PD profiles of longer-acting analogue insulins. Part one: The principles of glucose clamp studies |
| title_sort | practical guide to the interpretation of pk pd profiles of longer acting analogue insulins part one the principles of glucose clamp studies |
| topic | analogue insulins glucose clamp time–action profile glucose infusion rate pharmacokinetics |
| url | https://safpj.co.za/index.php/safpj/article/view/4874 |
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