Mannose-binding lectin may affect pregnancy outcome
Mannose-binding lectin (MBL) is a component of the innate immune system and acts as a complement activator through the lectin pathway. Genetic variations of MBL and low MBL levels cause several infection problems, which may also be related to pregnancy problems. We aimed to investigate the ro...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hacettepe University Institute of Child Health
2015-02-01
|
| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/1187 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850041851373944832 |
|---|---|
| author | Şebnem Çalkavur Fuat Akercan Ferda Özkınay Güzide Aksu Osman Zekioğlu Mehmet Yalaz Özge Altun Köroğlu Hüseyin Onay Gülin Erdemir Nilgün Kültürsay |
| author_facet | Şebnem Çalkavur Fuat Akercan Ferda Özkınay Güzide Aksu Osman Zekioğlu Mehmet Yalaz Özge Altun Köroğlu Hüseyin Onay Gülin Erdemir Nilgün Kültürsay |
| author_sort | Şebnem Çalkavur |
| collection | DOAJ |
| description |
Mannose-binding lectin (MBL) is a component of the innate immune system and acts as a complement activator through the lectin pathway. Genetic variations of MBL and low MBL levels cause several infection problems, which may also be related to pregnancy problems. We aimed to investigate the role of MBL gene codon 54 polymorphism and serum MBL levels in pregnancy problems and premature delivery. In this prospective study, MBL gene codon 54 polymorphism and serum MBL levels were studied in 45 mothers who delivered earlier than 35 gestational weeks. The frequency of MBL gene codon 54 variant allele B was much higher (homozygous 4.4% and heterozygous 33.3%) in the study group mothers than the previously reported frequency in the healthy Turkish population (homozygous 2-6%, heterozygous 12-20%). MBL variant allele B frequency was closely related to low MBL levels ( |
| format | Article |
| id | doaj-art-d479cdddbd36412d9988d3fc6ade562a |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2015-02-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-d479cdddbd36412d9988d3fc6ade562a2025-08-20T02:55:41ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212015-02-01571Mannose-binding lectin may affect pregnancy outcomeŞebnem Çalkavur0Fuat AkercanFerda ÖzkınayGüzide AksuOsman ZekioğluMehmet YalazÖzge Altun KöroğluHüseyin OnayGülin ErdemirNilgün KültürsayDivisions of Neonatology, Ege University Faculty of Medicine, İzmir, Turkey. mehmetyalaz35@gmail.com. Mannose-binding lectin (MBL) is a component of the innate immune system and acts as a complement activator through the lectin pathway. Genetic variations of MBL and low MBL levels cause several infection problems, which may also be related to pregnancy problems. We aimed to investigate the role of MBL gene codon 54 polymorphism and serum MBL levels in pregnancy problems and premature delivery. In this prospective study, MBL gene codon 54 polymorphism and serum MBL levels were studied in 45 mothers who delivered earlier than 35 gestational weeks. The frequency of MBL gene codon 54 variant allele B was much higher (homozygous 4.4% and heterozygous 33.3%) in the study group mothers than the previously reported frequency in the healthy Turkish population (homozygous 2-6%, heterozygous 12-20%). MBL variant allele B frequency was closely related to low MBL levels (https://turkjpediatr.org/article/view/1187 |
| spellingShingle | Şebnem Çalkavur Fuat Akercan Ferda Özkınay Güzide Aksu Osman Zekioğlu Mehmet Yalaz Özge Altun Köroğlu Hüseyin Onay Gülin Erdemir Nilgün Kültürsay Mannose-binding lectin may affect pregnancy outcome The Turkish Journal of Pediatrics |
| title | Mannose-binding lectin may affect pregnancy outcome |
| title_full | Mannose-binding lectin may affect pregnancy outcome |
| title_fullStr | Mannose-binding lectin may affect pregnancy outcome |
| title_full_unstemmed | Mannose-binding lectin may affect pregnancy outcome |
| title_short | Mannose-binding lectin may affect pregnancy outcome |
| title_sort | mannose binding lectin may affect pregnancy outcome |
| url | https://turkjpediatr.org/article/view/1187 |
| work_keys_str_mv | AT sebnemcalkavur mannosebindinglectinmayaffectpregnancyoutcome AT fuatakercan mannosebindinglectinmayaffectpregnancyoutcome AT ferdaozkınay mannosebindinglectinmayaffectpregnancyoutcome AT guzideaksu mannosebindinglectinmayaffectpregnancyoutcome AT osmanzekioglu mannosebindinglectinmayaffectpregnancyoutcome AT mehmetyalaz mannosebindinglectinmayaffectpregnancyoutcome AT ozgealtunkoroglu mannosebindinglectinmayaffectpregnancyoutcome AT huseyinonay mannosebindinglectinmayaffectpregnancyoutcome AT gulinerdemir mannosebindinglectinmayaffectpregnancyoutcome AT nilgunkultursay mannosebindinglectinmayaffectpregnancyoutcome |