Possible applications of gliptins (dipeptidyl peptidase-4 inhibitors) in patients with type 2 diabetes mellitus on the various modes of insulin therapy
The evidence for DPP-4 inhibitors effectiveness at the late stages of type 2 diabetes mellitus (T2DM) are still growing. This is particularly important for those patients who receive insulin without adequately glycemic control. This publication provides the overview of studies which demonstrate high...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2015-12-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/7624 |
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| author | Gagik Radikovich Galstyan Svetlana Viktorovna Sergeeva |
| author_facet | Gagik Radikovich Galstyan Svetlana Viktorovna Sergeeva |
| author_sort | Gagik Radikovich Galstyan |
| collection | DOAJ |
| description | The evidence for DPP-4 inhibitors effectiveness at the late stages of type 2 diabetes mellitus (T2DM) are still growing. This is particularly important for those patients who receive insulin without adequately glycemic control. This publication provides the overview of studies which demonstrate high efficacy of Vildagliptin in reducing the blood glucose level in patients with hight duration of T2DM and insulin therapy. DPP-4 inhibitors normalize basal and postprandial glucagon secretion with pancreas α-cells that helps to provide better glycemic control and to reduce a risk of hypoglycemia. Besides, there are very interesting data for Vildagliptin to reduce insulin requirement in T2DM patients in addition to HbA1clevel decrease. |
| format | Article |
| id | doaj-art-d475d6cca7794363a7a0ff5051ec970b |
| institution | Kabale University |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2015-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-d475d6cca7794363a7a0ff5051ec970b2025-08-20T03:47:53ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782015-12-01184879110.14341/DM76247249Possible applications of gliptins (dipeptidyl peptidase-4 inhibitors) in patients with type 2 diabetes mellitus on the various modes of insulin therapyGagik Radikovich Galstyan0Svetlana Viktorovna Sergeeva1Endocrinology Research Centre; Sechenov First Moscow State Medical UniversityEndocrinology Research CentreThe evidence for DPP-4 inhibitors effectiveness at the late stages of type 2 diabetes mellitus (T2DM) are still growing. This is particularly important for those patients who receive insulin without adequately glycemic control. This publication provides the overview of studies which demonstrate high efficacy of Vildagliptin in reducing the blood glucose level in patients with hight duration of T2DM and insulin therapy. DPP-4 inhibitors normalize basal and postprandial glucagon secretion with pancreas α-cells that helps to provide better glycemic control and to reduce a risk of hypoglycemia. Besides, there are very interesting data for Vildagliptin to reduce insulin requirement in T2DM patients in addition to HbA1clevel decrease.https://www.dia-endojournals.ru/jour/article/view/7624dipeptidyl peptidase-4 inhibitorsdiabetes mellitus 2 typeinsulin therapyvildagliptin |
| spellingShingle | Gagik Radikovich Galstyan Svetlana Viktorovna Sergeeva Possible applications of gliptins (dipeptidyl peptidase-4 inhibitors) in patients with type 2 diabetes mellitus on the various modes of insulin therapy Сахарный диабет dipeptidyl peptidase-4 inhibitors diabetes mellitus 2 type insulin therapy vildagliptin |
| title | Possible applications of gliptins (dipeptidyl peptidase-4 inhibitors) in patients with type 2 diabetes mellitus on the various modes of insulin therapy |
| title_full | Possible applications of gliptins (dipeptidyl peptidase-4 inhibitors) in patients with type 2 diabetes mellitus on the various modes of insulin therapy |
| title_fullStr | Possible applications of gliptins (dipeptidyl peptidase-4 inhibitors) in patients with type 2 diabetes mellitus on the various modes of insulin therapy |
| title_full_unstemmed | Possible applications of gliptins (dipeptidyl peptidase-4 inhibitors) in patients with type 2 diabetes mellitus on the various modes of insulin therapy |
| title_short | Possible applications of gliptins (dipeptidyl peptidase-4 inhibitors) in patients with type 2 diabetes mellitus on the various modes of insulin therapy |
| title_sort | possible applications of gliptins dipeptidyl peptidase 4 inhibitors in patients with type 2 diabetes mellitus on the various modes of insulin therapy |
| topic | dipeptidyl peptidase-4 inhibitors diabetes mellitus 2 type insulin therapy vildagliptin |
| url | https://www.dia-endojournals.ru/jour/article/view/7624 |
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