Extracellular Vesicles From Prostate Cancer‐Corrupted Osteoclasts Drive a Chain Reaction of Inflammatory Osteolysis and Tumour Progression at the Bone Metastatic Site

Extracellular Vesicles From Prostate Cancer‐Corrupted Osteoclasts Drive a Chain Reaction of Inflammatory Osteolysis and Tumour Progression at the Bone Metastatic Site

ABSTRACT Advanced‐stage prostate cancer (PCa) frequently causes bone metastases, resulting in a poor prognosis and a 5‐year survival rate of 30%. PCa bone metastasis is a highly complex and fluctuating process, comprising of osteolytic (bone‐degrading) and osteogenic (bone‐forming) lesions. Although...

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Bibliographic Details
Main Authors: Takaaki Tamura, Tomofumi Yamamoto, Akiko Kogure, Yusuke Yoshioka, Yusuke Yamamoto, Shinichi Sakamoto, Tomohiko Ichikawa, Takahiro Ochiya
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Journal of Extracellular Vesicles
Subjects:
bone metastasis
extracellular vesicles
IL‐1β
osteoclast
prostate cancer
Online Access:https://doi.org/10.1002/jev2.70091
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