Decreased Expression of Thyroglobulin and Sodium Iodide Symporter Genes in Hashimoto’s Thyroiditis

Aim. The aim of the study was to compare the expression of sodium iodide symporter (NIS), thyroglobulin (Tg), tumor necrosis factor-α (TNFα), and interleukin-1β genes in patients with Hashimoto’s thyroiditis (HT) and healthy individuals. Subjects and Methods. Thyroid cells were obtained from 39 pati...

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Main Authors: Anna Popławska-Kita, Beata Telejko, Katarzyna Siewko, Maria Kościuszko-Zdrodowska, Natalia Wawrusewicz-Kurylonek, Adam Krętowski, Justyna Hryniewicka, Janusz Dzięcioł, Witold Bauer, Robert Milewski, Małgorzata Szelachowska, Maria Górska
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:International Journal of Endocrinology
Online Access:http://dx.doi.org/10.1155/2014/690704
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Summary:Aim. The aim of the study was to compare the expression of sodium iodide symporter (NIS), thyroglobulin (Tg), tumor necrosis factor-α (TNFα), and interleukin-1β genes in patients with Hashimoto’s thyroiditis (HT) and healthy individuals. Subjects and Methods. Thyroid cells were obtained from 39 patients with HT and 15 controls by an ultrasound guided fine needle aspiration biopsy. Results. The patients with HT had lower Tg and NIS mRNA (P=0.002 and P=0.001, resp.), as well as higher TNFα mRNA expression (P=0.049) than the controls. In the HT group Tg mRNA expression correlated positively with NIS mRNA expression (R=0.739, P=0.0001) and thyroid volume (R=0.465, P=0.0005), as well as negatively with TNFα mRNA expression (R=-0.490, P=0.001) and anti-peroxidase antibodies (TPOAb) level (R=-0.482, P=0.0002), whereas NIS mRNA expression correlated positively with thyroid volume (R=0.319, P=0.02), as well as negatively with TNFα mRNA expression (R=-0.529, P=0.0006) and TPOAb level (R=-0.422, P=0.001). Conclusions. Our results suggest that decreased Tg and NIS expression in thyroid cells may result in reduced active iodide transport and reduced thyroid volume in patients with HT.
ISSN:1687-8337
1687-8345