Broad-spectrum coronavirus vaccines: integrated strategies to combat viral diversity
Introduction The early 21st century witnessed three consecutive public health emergencies caused by Betacoronavirus infections, drawing considerable global attention to the hazards posed by Betacoronaviruses. Vaccines have proved instrumental in mitigating the coronavirus disease 2019 (COVID-19) pan...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Expert Review of Vaccines |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/14760584.2025.2538561 |
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| _version_ | 1849247113933750272 |
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| author | Qian He Yi Zhang Zhihao Fu Xiao Ma Zhenglun Liang |
| author_facet | Qian He Yi Zhang Zhihao Fu Xiao Ma Zhenglun Liang |
| author_sort | Qian He |
| collection | DOAJ |
| description | Introduction The early 21st century witnessed three consecutive public health emergencies caused by Betacoronavirus infections, drawing considerable global attention to the hazards posed by Betacoronaviruses. Vaccines have proved instrumental in mitigating the coronavirus disease 2019 (COVID-19) pandemic, yet the persistent emergence of novel variants underscores the necessity for continuous development of updated vaccines tailored to circulating strains. In addition, new coronavirus outbreaks or the reemerging of previously prevalent coronaviruses may occur in the future.Areas covered Broad-spectrum coronavirus vaccines, especially pan-coronavirus vaccines, can serve as powerful weapons against known and unknown coronavirus risks. This article presents a comprehensive review of recent advancements in broad-spectrum coronavirus vaccine development, identifies persistent challenges, and outlines strategic directions for vaccine development. It aims to provide essential references and strategic considerations for broad-spectrum or universal coronavirus vaccines.Expert opinion Prioritizing Betacoronavirus-focused vaccines may provide practical near-term solutions, while long-term success hinges on integrating AI and structural biology for precision engineering. Future efforts must emphasize durable immunity, mucosal strategies, and adaptability to viral diversity. Collaboration across computational, immunological, and virological fields will be essential to achieve universal coronavirus protection. |
| format | Article |
| id | doaj-art-d46db1c19f2647619617cc300d5474bc |
| institution | Kabale University |
| issn | 1476-0584 1744-8395 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Expert Review of Vaccines |
| spelling | doaj-art-d46db1c19f2647619617cc300d5474bc2025-08-20T03:58:18ZengTaylor & Francis GroupExpert Review of Vaccines1476-05841744-83952025-12-0124172673710.1080/14760584.2025.2538561Broad-spectrum coronavirus vaccines: integrated strategies to combat viral diversityQian He0Yi Zhang1Zhihao Fu2Xiao Ma3Zhenglun Liang4State Key Laboratory of Drug Regulatory Science, Evaluation of Biological Products, Key Laboratory of Research On Quality and Standardization of Biotech Products, Institute of Biological Products, National Institutes for Food and Drug Control, Beijing, ChinaShanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, ChinaState Key Laboratory of Drug Regulatory Science, Evaluation of Biological Products, Key Laboratory of Research On Quality and Standardization of Biotech Products, Institute of Biological Products, National Institutes for Food and Drug Control, Beijing, ChinaState Key Laboratory of Drug Regulatory Science, Evaluation of Biological Products, Key Laboratory of Research On Quality and Standardization of Biotech Products, Institute of Biological Products, National Institutes for Food and Drug Control, Beijing, ChinaState Key Laboratory of Drug Regulatory Science, Evaluation of Biological Products, Key Laboratory of Research On Quality and Standardization of Biotech Products, Institute of Biological Products, National Institutes for Food and Drug Control, Beijing, ChinaIntroduction The early 21st century witnessed three consecutive public health emergencies caused by Betacoronavirus infections, drawing considerable global attention to the hazards posed by Betacoronaviruses. Vaccines have proved instrumental in mitigating the coronavirus disease 2019 (COVID-19) pandemic, yet the persistent emergence of novel variants underscores the necessity for continuous development of updated vaccines tailored to circulating strains. In addition, new coronavirus outbreaks or the reemerging of previously prevalent coronaviruses may occur in the future.Areas covered Broad-spectrum coronavirus vaccines, especially pan-coronavirus vaccines, can serve as powerful weapons against known and unknown coronavirus risks. This article presents a comprehensive review of recent advancements in broad-spectrum coronavirus vaccine development, identifies persistent challenges, and outlines strategic directions for vaccine development. It aims to provide essential references and strategic considerations for broad-spectrum or universal coronavirus vaccines.Expert opinion Prioritizing Betacoronavirus-focused vaccines may provide practical near-term solutions, while long-term success hinges on integrating AI and structural biology for precision engineering. Future efforts must emphasize durable immunity, mucosal strategies, and adaptability to viral diversity. Collaboration across computational, immunological, and virological fields will be essential to achieve universal coronavirus protection.https://www.tandfonline.com/doi/10.1080/14760584.2025.2538561Broad-spectrum vaccinepan-coronavirus vaccineBetacoronaviruscross-reactive immunityantigen design |
| spellingShingle | Qian He Yi Zhang Zhihao Fu Xiao Ma Zhenglun Liang Broad-spectrum coronavirus vaccines: integrated strategies to combat viral diversity Expert Review of Vaccines Broad-spectrum vaccine pan-coronavirus vaccine Betacoronavirus cross-reactive immunity antigen design |
| title | Broad-spectrum coronavirus vaccines: integrated strategies to combat viral diversity |
| title_full | Broad-spectrum coronavirus vaccines: integrated strategies to combat viral diversity |
| title_fullStr | Broad-spectrum coronavirus vaccines: integrated strategies to combat viral diversity |
| title_full_unstemmed | Broad-spectrum coronavirus vaccines: integrated strategies to combat viral diversity |
| title_short | Broad-spectrum coronavirus vaccines: integrated strategies to combat viral diversity |
| title_sort | broad spectrum coronavirus vaccines integrated strategies to combat viral diversity |
| topic | Broad-spectrum vaccine pan-coronavirus vaccine Betacoronavirus cross-reactive immunity antigen design |
| url | https://www.tandfonline.com/doi/10.1080/14760584.2025.2538561 |
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