Age‐related changes in behavior profile in male offspring of rats treated with poly I:C‐induced maternal immune activation in early gestation
Abstract Background Autism and schizophrenia are environmental risk factors associated with prenatal viral infection during pregnancy. It is still unclear whether behavior phenotypes change at different developmental stages in offspring following the activation of the maternal immune system. Methods...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Animal Models and Experimental Medicine |
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| Online Access: | https://doi.org/10.1002/ame2.12417 |
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| author | Tengfei Chen Huadan Meng Ni Fang Peiling Shi Mengxue Chen Qing Liu Luxian Lv Wenqiang Li |
| author_facet | Tengfei Chen Huadan Meng Ni Fang Peiling Shi Mengxue Chen Qing Liu Luxian Lv Wenqiang Li |
| author_sort | Tengfei Chen |
| collection | DOAJ |
| description | Abstract Background Autism and schizophrenia are environmental risk factors associated with prenatal viral infection during pregnancy. It is still unclear whether behavior phenotypes change at different developmental stages in offspring following the activation of the maternal immune system. Methods Sprague–Dawley rats received a single caudal vein injection of 10 mg/kg polyinosinic:polycytidylic acid (poly I:C) on gestational day 9 and the offspring were comprehensively tested for behaviors in adolescence and adulthood. Results Maternal serum levels of interleukin (IL)‐6, IL‐1β and tumor necrosis factor‐α were elevated in poly I:C‐treated dams. The offspring of maternal poly I:C‐induced rats showed increased anxiety, impaired social approach, and progressive impaired cognitive and sensorimotor gating function. Conclusion Maternal immune activation led to developmental specificity behavioral impairment in offspring. |
| format | Article |
| id | doaj-art-d4625adecf3645e6938e5500a0fb2141 |
| institution | DOAJ |
| issn | 2576-2095 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Animal Models and Experimental Medicine |
| spelling | doaj-art-d4625adecf3645e6938e5500a0fb21412025-08-20T02:39:43ZengWileyAnimal Models and Experimental Medicine2576-20952024-12-017691492510.1002/ame2.12417Age‐related changes in behavior profile in male offspring of rats treated with poly I:C‐induced maternal immune activation in early gestationTengfei Chen0Huadan Meng1Ni Fang2Peiling Shi3Mengxue Chen4Qing Liu5Luxian Lv6Wenqiang Li7Henan Mental Hospital The Second Affiliated Hospital of Xinxiang Medical University Xinxiang ChinaHenan Mental Hospital The Second Affiliated Hospital of Xinxiang Medical University Xinxiang ChinaHenan Mental Hospital The Second Affiliated Hospital of Xinxiang Medical University Xinxiang ChinaHenan Mental Hospital The Second Affiliated Hospital of Xinxiang Medical University Xinxiang ChinaHenan Mental Hospital The Second Affiliated Hospital of Xinxiang Medical University Xinxiang ChinaHenan Mental Hospital The Second Affiliated Hospital of Xinxiang Medical University Xinxiang ChinaHenan Mental Hospital The Second Affiliated Hospital of Xinxiang Medical University Xinxiang ChinaHenan Mental Hospital The Second Affiliated Hospital of Xinxiang Medical University Xinxiang ChinaAbstract Background Autism and schizophrenia are environmental risk factors associated with prenatal viral infection during pregnancy. It is still unclear whether behavior phenotypes change at different developmental stages in offspring following the activation of the maternal immune system. Methods Sprague–Dawley rats received a single caudal vein injection of 10 mg/kg polyinosinic:polycytidylic acid (poly I:C) on gestational day 9 and the offspring were comprehensively tested for behaviors in adolescence and adulthood. Results Maternal serum levels of interleukin (IL)‐6, IL‐1β and tumor necrosis factor‐α were elevated in poly I:C‐treated dams. The offspring of maternal poly I:C‐induced rats showed increased anxiety, impaired social approach, and progressive impaired cognitive and sensorimotor gating function. Conclusion Maternal immune activation led to developmental specificity behavioral impairment in offspring.https://doi.org/10.1002/ame2.12417behaviormaternal immune activepoly I:Crat |
| spellingShingle | Tengfei Chen Huadan Meng Ni Fang Peiling Shi Mengxue Chen Qing Liu Luxian Lv Wenqiang Li Age‐related changes in behavior profile in male offspring of rats treated with poly I:C‐induced maternal immune activation in early gestation Animal Models and Experimental Medicine behavior maternal immune active poly I:C rat |
| title | Age‐related changes in behavior profile in male offspring of rats treated with poly I:C‐induced maternal immune activation in early gestation |
| title_full | Age‐related changes in behavior profile in male offspring of rats treated with poly I:C‐induced maternal immune activation in early gestation |
| title_fullStr | Age‐related changes in behavior profile in male offspring of rats treated with poly I:C‐induced maternal immune activation in early gestation |
| title_full_unstemmed | Age‐related changes in behavior profile in male offspring of rats treated with poly I:C‐induced maternal immune activation in early gestation |
| title_short | Age‐related changes in behavior profile in male offspring of rats treated with poly I:C‐induced maternal immune activation in early gestation |
| title_sort | age related changes in behavior profile in male offspring of rats treated with poly i c induced maternal immune activation in early gestation |
| topic | behavior maternal immune active poly I:C rat |
| url | https://doi.org/10.1002/ame2.12417 |
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