Comprehensive analysis of endoscopic ultrasound (EUS) in mediastinal lesions: patient characteristics, diagnostic outcomes, safety, and efficacy: a multi-country study
Abstract Background Mediastinal lesions are tumors that develop mainly from structures commonly located in the three compartments of the mediastinum and the paravertebral areas. The diagnosis of these lesions is primarily based on imaging studies such as computed tomography and magnetic resonance im...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2025-02-01
|
| Series: | The Egyptian Journal of Internal Medicine |
| Online Access: | https://doi.org/10.1186/s43162-025-00409-w |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823861595724316672 |
|---|---|
| author | Hussein Okasha Eyad Gadour Ghias Un Nabi Tayyab Andrada Seicean Elbacha Hicham Emad Emad Turki Alamri Nadeem Tehami Heero Ismael Faraj Ahmed Alzamzamy Hiwa Hussein Mohammed Tag-Adeen Mohamed Elbasiony Abed Al-Lehibi Shereen Saleh Zaher Houmani Mohamed Abdelghani Khaled Ragab Zahi Ismaili Othmane Drir Elsayed Ghoneem Omar Abdallah Souad Rebiai Nonthalee Pausawasdi Fedoua Rouibaa Mohamed Borahma Hassan Atalla Mahmoud Farouk Ahmed Altonbary |
| author_facet | Hussein Okasha Eyad Gadour Ghias Un Nabi Tayyab Andrada Seicean Elbacha Hicham Emad Emad Turki Alamri Nadeem Tehami Heero Ismael Faraj Ahmed Alzamzamy Hiwa Hussein Mohammed Tag-Adeen Mohamed Elbasiony Abed Al-Lehibi Shereen Saleh Zaher Houmani Mohamed Abdelghani Khaled Ragab Zahi Ismaili Othmane Drir Elsayed Ghoneem Omar Abdallah Souad Rebiai Nonthalee Pausawasdi Fedoua Rouibaa Mohamed Borahma Hassan Atalla Mahmoud Farouk Ahmed Altonbary |
| author_sort | Hussein Okasha |
| collection | DOAJ |
| description | Abstract Background Mediastinal lesions are tumors that develop mainly from structures commonly located in the three compartments of the mediastinum and the paravertebral areas. The diagnosis of these lesions is primarily based on imaging studies such as computed tomography and magnetic resonance imaging, which confirm the presence of the lesions and suspected metastatic disease. The study aims to determine the factors that determine the diagnostic accuracy and yield of endoscopic ultrasound (EUS) in diagnosing mediastinal lesions. Methods This multi-country study involved a list of centers providing EUS services across ten countries—the United Kingdom, Algeria, Egypt, Iraq, Kingdom of Saudi Arabia (KSA), Lebanon, Morocco, Pakistan, Romania, and Thailand. The appropriate information was collected regarding EUS-FNA and EUS-FNB procedures, including needle types, nature of lesion, needle passes, and complications of the techniques. The frequency/percentage conveyed data on the qualitative variables. The p-values were obtained using the Chi-square two-tailed exact test. The significance of the analysis was defined as p < 0.05. All the syntheses were performed using the Statistical Package for the Social Sciences (SPSS version 27; SPSS Inc., Chicago, IL, USA). Results A total of 439 participants were involved in this study, 255 (58.1%) males and 184 (41.9%) females, with a mean age of 55.73 $$\pm$$ ± 14.93 years. EUS-FNA and EUS-FNB diagnostic yield was influenced by needle types, needle size, number of needle passes, and lesion size. Among females, 44.6% were diagnosed with EUS-FNA, 42.8% with EUS-FNB, and 50.0% with EUS-FNA and FNB. Conversely, 55.4% of males were diagnosed using EUS-FNA and 57.2% with EUS-FNB. The association between gender and the diagnostic method, however, was statistically insignificant (p = 0.197). Needles with smaller diameters (22G) offered greater diagnostic yield than needles with larger diameters (19G). A minimal number of needle passes (between 2 and 4) showed a higher diagnostic yield than a higher number of needle passes (> 5). EUS-FNB accounted for a 0.5% complication incidence rate each for fever, pain, thoracic pain, and hemorrhage. EUS-FNA had no complication rate. Patients undergoing EUS-FNA, EUS-FNB, or both procedural examinations had no significant complications (p = 0.085). Conclusion The diagnostic yield of EUS procedures is affected by needle types, number of needle passes, lesion size, and needle size. Besides, EUS-FNA and EUS-FNB are infrequently associated with various complication rates. These techniques are safe and offer higher diagnostic yield when utilized responsibly by endosonographers. |
| format | Article |
| id | doaj-art-d45991a71b3a4d2cbea08b8f0c398cda |
| institution | Kabale University |
| issn | 2090-9098 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Internal Medicine |
| spelling | doaj-art-d45991a71b3a4d2cbea08b8f0c398cda2025-02-09T12:55:10ZengSpringerOpenThe Egyptian Journal of Internal Medicine2090-90982025-02-0137111410.1186/s43162-025-00409-wComprehensive analysis of endoscopic ultrasound (EUS) in mediastinal lesions: patient characteristics, diagnostic outcomes, safety, and efficacy: a multi-country studyHussein Okasha0Eyad Gadour1Ghias Un Nabi Tayyab2Andrada Seicean3Elbacha Hicham4Emad Emad5Turki Alamri6Nadeem Tehami7Heero Ismael Faraj8Ahmed Alzamzamy9Hiwa Hussein10Mohammed Tag-Adeen11Mohamed Elbasiony12Abed Al-Lehibi13Shereen Saleh14Zaher Houmani15Mohamed Abdelghani16Khaled Ragab17Zahi Ismaili18Othmane Drir19Elsayed Ghoneem20Omar Abdallah21Souad Rebiai22Nonthalee Pausawasdi23Fedoua Rouibaa24Mohamed Borahma25Hassan Atalla26Mahmoud Farouk27Ahmed Altonbary28Gastroenterology Section, Department of Medicine, Kasr Alaini School of Medicine, Cairo UniversityMulti-Organ Transplant Centre of Excellence, Liver Transplantation Unit, King Fahad Specialist HospitalDepartment of Gastroenterology, Doctors Hospital and Medical CentreIuliu Hațieganu University of Medicine and PharmacyGastroenterology Department, Hospital ibn Sina University Mohamed VGastroenterology Division, Faculty of Medicine, King Abdul Aziz University HospitalDepartment of Internal Medicine, Gastroenterology Unit, Imam Abdulrahman Bin Faisal UniversityHepatology and Hepatobiliary Medicine, University Hospital Southampton NHS Foundation TrustSulaimaniyah Gastroenterology and Hepatology Teaching Hospital Medical SchoolDepartment of Gastroenterology and Hepatology, Maadi Armed Forces Medical ComplexSulaimaniyah Gastroenterology and Hepatology Teaching Hospital Medical SchoolDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Qena Faculty of MedicineDepartment of Internal Medicine, Mansoura University HospitalGastroenterology and Hepatology Department, King Fahd Medical CityGastroenterology and Hepatology Department, Ain Shams University HospitalGastroenterology and Endoscopy Department, Lebanese University, Faculty of Medicine, Najdeh HospitalTropical Medicine and Gastroenterology Department, Assiut University Hospitals, Theodor Bilharz Research InstituteInterventional Endoscopy Department, Mohammed VI Teaching HospitalDepartment of Gastroenterology and Interventional Endoscopy, Fatema el Azhar Oncology and Radiotherapy CentreGastroenterology and Hepatology, Internal Medicine Department, Mansoura University HospitalGastroenterology and Hepatology, Internal Medicine Department, Mansoura University HospitalREBIAI Gastroenterology and Interventional Endoscopy Department, Chifa Clinic HydraSiriraj Gastrointestinal Endoscopy Centre, Division of Gastroenterology, Siriraj HospitalGastrointestinal Endoscopy Centre, Military hospital Mohamed V-Souissi UniversityDepartment of Gastroenterology, Mohammed V University, Ibn Sina HospitalHepatology and Gastroenterology Unit, Mansoura University HospitalTropical Medicine and Gastroenterology, Luxor UniversityDepartment of Gastroenterology and Hepatology, Mansoura Specialized Medical Hospital, Mansoura University HospitalAbstract Background Mediastinal lesions are tumors that develop mainly from structures commonly located in the three compartments of the mediastinum and the paravertebral areas. The diagnosis of these lesions is primarily based on imaging studies such as computed tomography and magnetic resonance imaging, which confirm the presence of the lesions and suspected metastatic disease. The study aims to determine the factors that determine the diagnostic accuracy and yield of endoscopic ultrasound (EUS) in diagnosing mediastinal lesions. Methods This multi-country study involved a list of centers providing EUS services across ten countries—the United Kingdom, Algeria, Egypt, Iraq, Kingdom of Saudi Arabia (KSA), Lebanon, Morocco, Pakistan, Romania, and Thailand. The appropriate information was collected regarding EUS-FNA and EUS-FNB procedures, including needle types, nature of lesion, needle passes, and complications of the techniques. The frequency/percentage conveyed data on the qualitative variables. The p-values were obtained using the Chi-square two-tailed exact test. The significance of the analysis was defined as p < 0.05. All the syntheses were performed using the Statistical Package for the Social Sciences (SPSS version 27; SPSS Inc., Chicago, IL, USA). Results A total of 439 participants were involved in this study, 255 (58.1%) males and 184 (41.9%) females, with a mean age of 55.73 $$\pm$$ ± 14.93 years. EUS-FNA and EUS-FNB diagnostic yield was influenced by needle types, needle size, number of needle passes, and lesion size. Among females, 44.6% were diagnosed with EUS-FNA, 42.8% with EUS-FNB, and 50.0% with EUS-FNA and FNB. Conversely, 55.4% of males were diagnosed using EUS-FNA and 57.2% with EUS-FNB. The association between gender and the diagnostic method, however, was statistically insignificant (p = 0.197). Needles with smaller diameters (22G) offered greater diagnostic yield than needles with larger diameters (19G). A minimal number of needle passes (between 2 and 4) showed a higher diagnostic yield than a higher number of needle passes (> 5). EUS-FNB accounted for a 0.5% complication incidence rate each for fever, pain, thoracic pain, and hemorrhage. EUS-FNA had no complication rate. Patients undergoing EUS-FNA, EUS-FNB, or both procedural examinations had no significant complications (p = 0.085). Conclusion The diagnostic yield of EUS procedures is affected by needle types, number of needle passes, lesion size, and needle size. Besides, EUS-FNA and EUS-FNB are infrequently associated with various complication rates. These techniques are safe and offer higher diagnostic yield when utilized responsibly by endosonographers.https://doi.org/10.1186/s43162-025-00409-w |
| spellingShingle | Hussein Okasha Eyad Gadour Ghias Un Nabi Tayyab Andrada Seicean Elbacha Hicham Emad Emad Turki Alamri Nadeem Tehami Heero Ismael Faraj Ahmed Alzamzamy Hiwa Hussein Mohammed Tag-Adeen Mohamed Elbasiony Abed Al-Lehibi Shereen Saleh Zaher Houmani Mohamed Abdelghani Khaled Ragab Zahi Ismaili Othmane Drir Elsayed Ghoneem Omar Abdallah Souad Rebiai Nonthalee Pausawasdi Fedoua Rouibaa Mohamed Borahma Hassan Atalla Mahmoud Farouk Ahmed Altonbary Comprehensive analysis of endoscopic ultrasound (EUS) in mediastinal lesions: patient characteristics, diagnostic outcomes, safety, and efficacy: a multi-country study The Egyptian Journal of Internal Medicine |
| title | Comprehensive analysis of endoscopic ultrasound (EUS) in mediastinal lesions: patient characteristics, diagnostic outcomes, safety, and efficacy: a multi-country study |
| title_full | Comprehensive analysis of endoscopic ultrasound (EUS) in mediastinal lesions: patient characteristics, diagnostic outcomes, safety, and efficacy: a multi-country study |
| title_fullStr | Comprehensive analysis of endoscopic ultrasound (EUS) in mediastinal lesions: patient characteristics, diagnostic outcomes, safety, and efficacy: a multi-country study |
| title_full_unstemmed | Comprehensive analysis of endoscopic ultrasound (EUS) in mediastinal lesions: patient characteristics, diagnostic outcomes, safety, and efficacy: a multi-country study |
| title_short | Comprehensive analysis of endoscopic ultrasound (EUS) in mediastinal lesions: patient characteristics, diagnostic outcomes, safety, and efficacy: a multi-country study |
| title_sort | comprehensive analysis of endoscopic ultrasound eus in mediastinal lesions patient characteristics diagnostic outcomes safety and efficacy a multi country study |
| url | https://doi.org/10.1186/s43162-025-00409-w |
| work_keys_str_mv | AT husseinokasha comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT eyadgadour comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT ghiasunnabitayyab comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT andradaseicean comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT elbachahicham comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT emademad comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT turkialamri comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT nadeemtehami comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT heeroismaelfaraj comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT ahmedalzamzamy comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT hiwahussein comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT mohammedtagadeen comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT mohamedelbasiony comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT abedallehibi comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT shereensaleh comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT zaherhoumani comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT mohamedabdelghani comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT khaledragab comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT zahiismaili comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT othmanedrir comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT elsayedghoneem comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT omarabdallah comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT souadrebiai comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT nonthaleepausawasdi comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT fedouarouibaa comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT mohamedborahma comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT hassanatalla comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT mahmoudfarouk comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy AT ahmedaltonbary comprehensiveanalysisofendoscopicultrasoundeusinmediastinallesionspatientcharacteristicsdiagnosticoutcomessafetyandefficacyamulticountrystudy |