Novel serum biomarker associations with 7 Tesla MRI-defined cortical lesions, leptomeningeal enhancement, and deep gray matter volume in early multiple sclerosis
Abstract Gray matter demyelinating lesions, brain atrophy and meningeal inflammation are hypothesized to be relevant in multiple sclerosis (MS) disease pathogenesis, though their relationship to immune alterations in early MS is not well characterized. This study aims to investigate correlations bet...
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Nature Portfolio
2025-04-01
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| Online Access: | https://doi.org/10.1038/s41598-025-95229-x |
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| author | Andrei Miclea Jonathan Zurawski Brian C. Healy Shrishti Saxena Hrishikesh Lokhande Molly Quattrucci Renxin Chu Howard L. Weiner Rohit Bakshi Tanuja Chitnis |
| author_facet | Andrei Miclea Jonathan Zurawski Brian C. Healy Shrishti Saxena Hrishikesh Lokhande Molly Quattrucci Renxin Chu Howard L. Weiner Rohit Bakshi Tanuja Chitnis |
| author_sort | Andrei Miclea |
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| description | Abstract Gray matter demyelinating lesions, brain atrophy and meningeal inflammation are hypothesized to be relevant in multiple sclerosis (MS) disease pathogenesis, though their relationship to immune alterations in early MS is not well characterized. This study aims to investigate correlations between the concentrations of 112 serum proteins and 7 Tesla MRI-defined measures of disease severity in patients with early MS. In this analysis, patients with CIS or MS having a 7 Tesla brain MRI and blood sample both within five years of MS diagnosis were included (n = 57). Correlational analysis was adjusted for sex, age, and disease duration. Correlation between serum proteins and MRI-defined cortical and thalamic gray matter lesions, leptomeningeal enhancement (presence and foci number), deep gray matter (DGM) structure volumes, whole brain parenchymal volume and total T2 white matter lesion volume was assessed. In this study, cortical lesions were associated with higher IL-15, TNF-alpha, and BAFF levels, and lower levels of FcRL2. Leptomeningeal enhancement was associated with higher levels of PLXNB3 and lower levels of nCDase and CNTN5. Higher IL-1B levels correlated with lower DGM volume while higher levels of CDH6, SIGLEC9, and HAGH correlated with higher DGM volume. These novel associations between serum immune proteins and 7 T MRI outcomes may have relevance as disease biomarkers in early stages of MS. |
| format | Article |
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| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
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| spelling | doaj-art-d457db412f774b3280bb8466ff8a94d42025-08-20T02:17:05ZengNature PortfolioScientific Reports2045-23222025-04-0115111410.1038/s41598-025-95229-xNovel serum biomarker associations with 7 Tesla MRI-defined cortical lesions, leptomeningeal enhancement, and deep gray matter volume in early multiple sclerosisAndrei Miclea0Jonathan Zurawski1Brian C. Healy2Shrishti Saxena3Hrishikesh Lokhande4Molly Quattrucci5Renxin Chu6Howard L. Weiner7Rohit Bakshi8Tanuja Chitnis9Brigham Multiple Sclerosis Center, Brigham and Women’s HospitalBrigham Multiple Sclerosis Center, Brigham and Women’s HospitalBrigham Multiple Sclerosis Center, Brigham and Women’s HospitalBrigham Multiple Sclerosis Center, Brigham and Women’s HospitalBrigham Multiple Sclerosis Center, Brigham and Women’s HospitalBrigham Multiple Sclerosis Center, Brigham and Women’s HospitalBrigham Multiple Sclerosis Center, Brigham and Women’s HospitalBrigham Multiple Sclerosis Center, Brigham and Women’s HospitalBrigham Multiple Sclerosis Center, Brigham and Women’s HospitalBrigham Multiple Sclerosis Center, Brigham and Women’s HospitalAbstract Gray matter demyelinating lesions, brain atrophy and meningeal inflammation are hypothesized to be relevant in multiple sclerosis (MS) disease pathogenesis, though their relationship to immune alterations in early MS is not well characterized. This study aims to investigate correlations between the concentrations of 112 serum proteins and 7 Tesla MRI-defined measures of disease severity in patients with early MS. In this analysis, patients with CIS or MS having a 7 Tesla brain MRI and blood sample both within five years of MS diagnosis were included (n = 57). Correlational analysis was adjusted for sex, age, and disease duration. Correlation between serum proteins and MRI-defined cortical and thalamic gray matter lesions, leptomeningeal enhancement (presence and foci number), deep gray matter (DGM) structure volumes, whole brain parenchymal volume and total T2 white matter lesion volume was assessed. In this study, cortical lesions were associated with higher IL-15, TNF-alpha, and BAFF levels, and lower levels of FcRL2. Leptomeningeal enhancement was associated with higher levels of PLXNB3 and lower levels of nCDase and CNTN5. Higher IL-1B levels correlated with lower DGM volume while higher levels of CDH6, SIGLEC9, and HAGH correlated with higher DGM volume. These novel associations between serum immune proteins and 7 T MRI outcomes may have relevance as disease biomarkers in early stages of MS.https://doi.org/10.1038/s41598-025-95229-xBiomarkers7 TeslaLeptomeningeal enhancementCortical lesionsDeep gray matter lesionsMultiple sclerosis |
| spellingShingle | Andrei Miclea Jonathan Zurawski Brian C. Healy Shrishti Saxena Hrishikesh Lokhande Molly Quattrucci Renxin Chu Howard L. Weiner Rohit Bakshi Tanuja Chitnis Novel serum biomarker associations with 7 Tesla MRI-defined cortical lesions, leptomeningeal enhancement, and deep gray matter volume in early multiple sclerosis Scientific Reports Biomarkers 7 Tesla Leptomeningeal enhancement Cortical lesions Deep gray matter lesions Multiple sclerosis |
| title | Novel serum biomarker associations with 7 Tesla MRI-defined cortical lesions, leptomeningeal enhancement, and deep gray matter volume in early multiple sclerosis |
| title_full | Novel serum biomarker associations with 7 Tesla MRI-defined cortical lesions, leptomeningeal enhancement, and deep gray matter volume in early multiple sclerosis |
| title_fullStr | Novel serum biomarker associations with 7 Tesla MRI-defined cortical lesions, leptomeningeal enhancement, and deep gray matter volume in early multiple sclerosis |
| title_full_unstemmed | Novel serum biomarker associations with 7 Tesla MRI-defined cortical lesions, leptomeningeal enhancement, and deep gray matter volume in early multiple sclerosis |
| title_short | Novel serum biomarker associations with 7 Tesla MRI-defined cortical lesions, leptomeningeal enhancement, and deep gray matter volume in early multiple sclerosis |
| title_sort | novel serum biomarker associations with 7 tesla mri defined cortical lesions leptomeningeal enhancement and deep gray matter volume in early multiple sclerosis |
| topic | Biomarkers 7 Tesla Leptomeningeal enhancement Cortical lesions Deep gray matter lesions Multiple sclerosis |
| url | https://doi.org/10.1038/s41598-025-95229-x |
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