Effect of Nedocromil Sodium on Aspecific Bronchial Hyper-Reactivity in Asthmatic Children
The purpose of this study was to evaluate whether nedocromil sodium benefits urban asthmatic children showing seasonal bronchial hyper-reactivity to ultrasonic nebulization of distilled water (UNDW). A prospective, randomized, placebo-controlled, parallel-group, double-blind study was carried out at...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S096293519400075X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849470157132398592 |
|---|---|
| author | A. Fiocchi P. Signoroni P. Bruni M. Galeone E. DeCet S. Bogacki |
| author_facet | A. Fiocchi P. Signoroni P. Bruni M. Galeone E. DeCet S. Bogacki |
| author_sort | A. Fiocchi |
| collection | DOAJ |
| description | The purpose of this study was to evaluate whether
nedocromil sodium benefits urban asthmatic children
showing seasonal bronchial hyper-reactivity to ultrasonic
nebulization of distilled water (UNDW). A prospective,
randomized, placebo-controlled, parallel-group,
double-blind study was carried out at the outpatient
pulmonology service at a tertiary-care teaching hospital.
Twelve children living in Milan, who were 7–17 years of
age, who were SPT and RAST-negative to perennial allergens,
who were suffering from episodic asthma, and
showing seasonal bronchial hyper-reactivity to UNDW
during winter, participated in this study. All the children
received either placebo or nedocromil sodium, 4 mg
every 6 h for 6 weeks. Spirometry and UNDW challenge
were done at the following times: day−7; day 0; day 1; day
7; day 14; day 28; day 42. No differences were found in
the basal spirometric parameters, which were normal in
both nedocromil and placebo groups. Bronchial reactivity
to UNDW was found to be significantly decreased in
the group treated with nedocromtl starting from day 7. It
is therefore concluded that nedocromil sodium can reverse
bronchial hyper-reactivity caused by seasonal factors
such as cold, viral infections and atmospheric pollutants
in children suffering from asthma. |
| format | Article |
| id | doaj-art-d4511ce1ac874601b1ea459f27afe3e2 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1994-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d4511ce1ac874601b1ea459f27afe3e22025-08-20T03:25:12ZengWileyMediators of Inflammation0962-93511466-18611994-01-0137S43S4710.1155/S096293519400075XEffect of Nedocromil Sodium on Aspecific Bronchial Hyper-Reactivity in Asthmatic ChildrenA. Fiocchi0P. Signoroni1P. Bruni2M. Galeone3E. DeCet4S. Bogacki55th Paediatric Department, University of Milan, Via Rossini, 2, Milan 20062, Italy5th Paediatric Department, University of Milan, Via Rossini, 2, Milan 20062, Italy5th Paediatric Department, University of Milan, Via Rossini, 2, Milan 20062, Italy5th Paediatric Department, University of Milan, Via Rossini, 2, Milan 20062, Italy5th Paediatric Department, University of Milan, Via Rossini, 2, Milan 20062, Italy5th Paediatric Department, University of Milan, Via Rossini, 2, Milan 20062, ItalyThe purpose of this study was to evaluate whether nedocromil sodium benefits urban asthmatic children showing seasonal bronchial hyper-reactivity to ultrasonic nebulization of distilled water (UNDW). A prospective, randomized, placebo-controlled, parallel-group, double-blind study was carried out at the outpatient pulmonology service at a tertiary-care teaching hospital. Twelve children living in Milan, who were 7–17 years of age, who were SPT and RAST-negative to perennial allergens, who were suffering from episodic asthma, and showing seasonal bronchial hyper-reactivity to UNDW during winter, participated in this study. All the children received either placebo or nedocromil sodium, 4 mg every 6 h for 6 weeks. Spirometry and UNDW challenge were done at the following times: day−7; day 0; day 1; day 7; day 14; day 28; day 42. No differences were found in the basal spirometric parameters, which were normal in both nedocromil and placebo groups. Bronchial reactivity to UNDW was found to be significantly decreased in the group treated with nedocromtl starting from day 7. It is therefore concluded that nedocromil sodium can reverse bronchial hyper-reactivity caused by seasonal factors such as cold, viral infections and atmospheric pollutants in children suffering from asthma.http://dx.doi.org/10.1155/S096293519400075X |
| spellingShingle | A. Fiocchi P. Signoroni P. Bruni M. Galeone E. DeCet S. Bogacki Effect of Nedocromil Sodium on Aspecific Bronchial Hyper-Reactivity in Asthmatic Children Mediators of Inflammation |
| title | Effect of Nedocromil Sodium on Aspecific Bronchial Hyper-Reactivity in Asthmatic Children |
| title_full | Effect of Nedocromil Sodium on Aspecific Bronchial Hyper-Reactivity in Asthmatic Children |
| title_fullStr | Effect of Nedocromil Sodium on Aspecific Bronchial Hyper-Reactivity in Asthmatic Children |
| title_full_unstemmed | Effect of Nedocromil Sodium on Aspecific Bronchial Hyper-Reactivity in Asthmatic Children |
| title_short | Effect of Nedocromil Sodium on Aspecific Bronchial Hyper-Reactivity in Asthmatic Children |
| title_sort | effect of nedocromil sodium on aspecific bronchial hyper reactivity in asthmatic children |
| url | http://dx.doi.org/10.1155/S096293519400075X |
| work_keys_str_mv | AT afiocchi effectofnedocromilsodiumonaspecificbronchialhyperreactivityinasthmaticchildren AT psignoroni effectofnedocromilsodiumonaspecificbronchialhyperreactivityinasthmaticchildren AT pbruni effectofnedocromilsodiumonaspecificbronchialhyperreactivityinasthmaticchildren AT mgaleone effectofnedocromilsodiumonaspecificbronchialhyperreactivityinasthmaticchildren AT edecet effectofnedocromilsodiumonaspecificbronchialhyperreactivityinasthmaticchildren AT sbogacki effectofnedocromilsodiumonaspecificbronchialhyperreactivityinasthmaticchildren |