Distribution, host origin, and transmission cycles of Trypanosoma cruzi genotypes in the State of Rio Grande do Norte, Brazil
ABSTRACT Background: The genetic diversity of Trypanosoma cruzi and the epidemiological characteristics of the environments in which the parasite occurs are essential for understanding infection dynamics and controlling Chagas disease. This systematic review aimed to: (i) identify and analyze studi...
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Sociedade Brasileira de Medicina Tropical (SBMT)
2025-08-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822025000100409&tlng=en |
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| author | George Harisson Felinto Sampaio Nathan Ravi Medeiros Honorato Lucas Abrantes Batista Maricélia de Aquino Santana Carlos Ramon do Nascimento Brito Rand Randall Martins Paulo Marcos da Matta Guedes Andressa Noronha Barbosa da Silva Lúcia Maria da Cunha Galvão |
| author_facet | George Harisson Felinto Sampaio Nathan Ravi Medeiros Honorato Lucas Abrantes Batista Maricélia de Aquino Santana Carlos Ramon do Nascimento Brito Rand Randall Martins Paulo Marcos da Matta Guedes Andressa Noronha Barbosa da Silva Lúcia Maria da Cunha Galvão |
| author_sort | George Harisson Felinto Sampaio |
| collection | DOAJ |
| description | ABSTRACT Background: The genetic diversity of Trypanosoma cruzi and the epidemiological characteristics of the environments in which the parasite occurs are essential for understanding infection dynamics and controlling Chagas disease. This systematic review aimed to: (i) identify and analyze studies that evaluated the genetic variability and epidemiological aspects of T. cruzi infection in the state of Rio Grande do Norte, Brazil; (ii) summarize the information reported in the literature; and (iii) suggest new control strategies tailored to the region’s epidemiological profile. Methods: Following the application of inclusion and exclusion criteria, 13 studies catalogued in PubMed, the Brazilian Virtual Health Library, Scopus, and the Web of Science were selected. Results: T. cruzi isolates were primarily obtained from triatomine species Triatoma brasiliensis, Panstrongylus lutzi, and Triatoma pseudomaculata, as well as from wild mammals such as Euphractus sexcinctus, Galea spixii, and humans. A total of 295 T. cruzi isolates were genotyped: 46.5% (137) were identified as Discrete Typing Unit (DTU) I, 29.1% (86) as DTU II, and 20% (59) as DTU III. Mixed infections were detected in 4.4% (13/295) of hosts. Triatomine species were found in both peridomestic and intradomestic environments and were occasionally infected with T. cruzi. Conclusions: This review provides a comprehensive overview of the circulation of distinct Trypanosoma cruzi genotypes (I, II, and III) in both wild and human-modified environments in Rio Grande do Norte. |
| format | Article |
| id | doaj-art-d44f23927eb244218f66e5f1b196aef9 |
| institution | Kabale University |
| issn | 1678-9849 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj-art-d44f23927eb244218f66e5f1b196aef92025-08-20T03:41:22ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492025-08-015810.1590/0037-8682-0063-2025Distribution, host origin, and transmission cycles of Trypanosoma cruzi genotypes in the State of Rio Grande do Norte, BrazilGeorge Harisson Felinto Sampaiohttps://orcid.org/0000-0001-9525-6532Nathan Ravi Medeiros Honoratohttps://orcid.org/0000-0002-5519-7926Lucas Abrantes Batistahttps://orcid.org/0000-0001-5149-0909Maricélia de Aquino Santanahttps://orcid.org/0000-0003-4218-3936Carlos Ramon do Nascimento Britohttps://orcid.org/0000-0003-4882-5215Rand Randall Martinshttps://orcid.org/0000-0001-9668-0482Paulo Marcos da Matta Guedeshttps://orcid.org/0000-0002-4564-6791Andressa Noronha Barbosa da Silvahttps://orcid.org/0000-0002-6584-5771Lúcia Maria da Cunha Galvãohttps://orcid.org/0000-0002-6207-4502ABSTRACT Background: The genetic diversity of Trypanosoma cruzi and the epidemiological characteristics of the environments in which the parasite occurs are essential for understanding infection dynamics and controlling Chagas disease. This systematic review aimed to: (i) identify and analyze studies that evaluated the genetic variability and epidemiological aspects of T. cruzi infection in the state of Rio Grande do Norte, Brazil; (ii) summarize the information reported in the literature; and (iii) suggest new control strategies tailored to the region’s epidemiological profile. Methods: Following the application of inclusion and exclusion criteria, 13 studies catalogued in PubMed, the Brazilian Virtual Health Library, Scopus, and the Web of Science were selected. Results: T. cruzi isolates were primarily obtained from triatomine species Triatoma brasiliensis, Panstrongylus lutzi, and Triatoma pseudomaculata, as well as from wild mammals such as Euphractus sexcinctus, Galea spixii, and humans. A total of 295 T. cruzi isolates were genotyped: 46.5% (137) were identified as Discrete Typing Unit (DTU) I, 29.1% (86) as DTU II, and 20% (59) as DTU III. Mixed infections were detected in 4.4% (13/295) of hosts. Triatomine species were found in both peridomestic and intradomestic environments and were occasionally infected with T. cruzi. Conclusions: This review provides a comprehensive overview of the circulation of distinct Trypanosoma cruzi genotypes (I, II, and III) in both wild and human-modified environments in Rio Grande do Norte.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822025000100409&tlng=enTrypanosoma cruziGenetic diversityTransmission cyclesInvertebrate and vertebrate hostsPublic health |
| spellingShingle | George Harisson Felinto Sampaio Nathan Ravi Medeiros Honorato Lucas Abrantes Batista Maricélia de Aquino Santana Carlos Ramon do Nascimento Brito Rand Randall Martins Paulo Marcos da Matta Guedes Andressa Noronha Barbosa da Silva Lúcia Maria da Cunha Galvão Distribution, host origin, and transmission cycles of Trypanosoma cruzi genotypes in the State of Rio Grande do Norte, Brazil Revista da Sociedade Brasileira de Medicina Tropical Trypanosoma cruzi Genetic diversity Transmission cycles Invertebrate and vertebrate hosts Public health |
| title | Distribution, host origin, and transmission cycles of Trypanosoma cruzi genotypes in the State of Rio Grande do Norte, Brazil |
| title_full | Distribution, host origin, and transmission cycles of Trypanosoma cruzi genotypes in the State of Rio Grande do Norte, Brazil |
| title_fullStr | Distribution, host origin, and transmission cycles of Trypanosoma cruzi genotypes in the State of Rio Grande do Norte, Brazil |
| title_full_unstemmed | Distribution, host origin, and transmission cycles of Trypanosoma cruzi genotypes in the State of Rio Grande do Norte, Brazil |
| title_short | Distribution, host origin, and transmission cycles of Trypanosoma cruzi genotypes in the State of Rio Grande do Norte, Brazil |
| title_sort | distribution host origin and transmission cycles of trypanosoma cruzi genotypes in the state of rio grande do norte brazil |
| topic | Trypanosoma cruzi Genetic diversity Transmission cycles Invertebrate and vertebrate hosts Public health |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822025000100409&tlng=en |
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