Distribution, host origin, and transmission cycles of Trypanosoma cruzi genotypes in the State of Rio Grande do Norte, Brazil

Distribution, host origin, and transmission cycles of Trypanosoma cruzi genotypes in the State of Rio Grande do Norte, Brazil

ABSTRACT Background: The genetic diversity of Trypanosoma cruzi and the epidemiological characteristics of the environments in which the parasite occurs are essential for understanding infection dynamics and controlling Chagas disease. This systematic review aimed to: (i) identify and analyze studi...

Full description

Saved in:
Bibliographic Details
Main Authors: George Harisson Felinto Sampaio, Nathan Ravi Medeiros Honorato, Lucas Abrantes Batista, Maricélia de Aquino Santana, Carlos Ramon do Nascimento Brito, Rand Randall Martins, Paulo Marcos da Matta Guedes, Andressa Noronha Barbosa da Silva, Lúcia Maria da Cunha Galvão
Format: Article
Language:English
Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2025-08-01
Series:Revista da Sociedade Brasileira de Medicina Tropical
Subjects:
Trypanosoma cruzi
Genetic diversity
Transmission cycles
Invertebrate and vertebrate hosts
Public health
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822025000100409&tlng=en
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Background: The genetic diversity of Trypanosoma cruzi and the epidemiological characteristics of the environments in which the parasite occurs are essential for understanding infection dynamics and controlling Chagas disease. This systematic review aimed to: (i) identify and analyze studies that evaluated the genetic variability and epidemiological aspects of T. cruzi infection in the state of Rio Grande do Norte, Brazil; (ii) summarize the information reported in the literature; and (iii) suggest new control strategies tailored to the region’s epidemiological profile. Methods: Following the application of inclusion and exclusion criteria, 13 studies catalogued in PubMed, the Brazilian Virtual Health Library, Scopus, and the Web of Science were selected. Results: T. cruzi isolates were primarily obtained from triatomine species Triatoma brasiliensis, Panstrongylus lutzi, and Triatoma pseudomaculata, as well as from wild mammals such as Euphractus sexcinctus, Galea spixii, and humans. A total of 295 T. cruzi isolates were genotyped: 46.5% (137) were identified as Discrete Typing Unit (DTU) I, 29.1% (86) as DTU II, and 20% (59) as DTU III. Mixed infections were detected in 4.4% (13/295) of hosts. Triatomine species were found in both peridomestic and intradomestic environments and were occasionally infected with T. cruzi. Conclusions: This review provides a comprehensive overview of the circulation of distinct Trypanosoma cruzi genotypes (I, II, and III) in both wild and human-modified environments in Rio Grande do Norte.
ISSN:1678-9849

Similar Items