Enzyme-constrained metabolic model of Treponema pallidum identified glycerol-3-phosphate dehydrogenase as an alternate electron sink

Enzyme-constrained metabolic model of Treponema pallidum identified glycerol-3-phosphate dehydrogenase as an alternate electron sink

ABSTRACT Treponema pallidum, the causative agent of syphilis, poses a significant global health threat. Its strict reliance on host-derived nutrients and difficulties in in vitro cultivation have impeded detailed metabolic characterization. In this study, we present iTP251, the first genome-scale me...

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Bibliographic Details
Main Authors: Nabia Shahreen, Niaz Bahar Chowdhury, Edward Stone, Elle Knobbe, Rajib Saha
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mSystems
Subjects:
Treponema pallidum
genome-scale metabolic model
enzyme-constrained modeling
alternative electron sink
glycerol-3-phosphate dehydrogenase
redox balance
Online Access:https://journals.asm.org/doi/10.1128/msystems.01555-24
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