Genome-wide association study of proneness to anger.
<h4>Background</h4>Community samples suggest that approximately 1 in 20 children and adults exhibit clinically significant anger, hostility, and aggression. Individuals with dysregulated emotional control have a greater lifetime burden of psychiatric morbidity, severe impairment in role...
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0087257&type=printable |
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| author | Eric Mick James McGough Curtis K Deutsch Jean A Frazier David Kennedy Robert J Goldberg |
| author_facet | Eric Mick James McGough Curtis K Deutsch Jean A Frazier David Kennedy Robert J Goldberg |
| author_sort | Eric Mick |
| collection | DOAJ |
| description | <h4>Background</h4>Community samples suggest that approximately 1 in 20 children and adults exhibit clinically significant anger, hostility, and aggression. Individuals with dysregulated emotional control have a greater lifetime burden of psychiatric morbidity, severe impairment in role functioning, and premature mortality due to cardiovascular disease.<h4>Methods</h4>With publically available data secured from dbGaP, we conducted a genome-wide association study of proneness to anger using the Spielberger State-Trait Anger Scale in the Atherosclerosis Risk in Communities (ARIC) study (n = 8,747).<h4>Results</h4>Subjects were, on average, 54 (range 45-64) years old at baseline enrollment, 47% (n = 4,117) were male, and all were of European descent by self-report. The mean Angry Temperament and Angry Reaction scores were 5.8 ± 1.8 and 7.6 ± 2.2. We observed a nominally significant finding (p = 2.9E-08, λ = 1.027 - corrected pgc = 2.2E-07, λ = 1.0015) on chromosome 6q21 in the gene coding for the non-receptor protein-tyrosine kinase, Fyn.<h4>Conclusions</h4>Fyn interacts with NDMA receptors and inositol-1,4,5-trisphosphate (IP3)-gated channels to regulate calcium influx and intracellular release in the post-synaptic density. These results suggest that signaling pathways regulating intracellular calcium homeostasis, which are relevant to memory, learning, and neuronal survival, may in part underlie the expression of Angry Temperament. |
| format | Article |
| id | doaj-art-d44a210f9a2f4107ae5b96ad39e37f72 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-d44a210f9a2f4107ae5b96ad39e37f722025-08-20T02:22:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0191e8725710.1371/journal.pone.0087257Genome-wide association study of proneness to anger.Eric MickJames McGoughCurtis K DeutschJean A FrazierDavid KennedyRobert J Goldberg<h4>Background</h4>Community samples suggest that approximately 1 in 20 children and adults exhibit clinically significant anger, hostility, and aggression. Individuals with dysregulated emotional control have a greater lifetime burden of psychiatric morbidity, severe impairment in role functioning, and premature mortality due to cardiovascular disease.<h4>Methods</h4>With publically available data secured from dbGaP, we conducted a genome-wide association study of proneness to anger using the Spielberger State-Trait Anger Scale in the Atherosclerosis Risk in Communities (ARIC) study (n = 8,747).<h4>Results</h4>Subjects were, on average, 54 (range 45-64) years old at baseline enrollment, 47% (n = 4,117) were male, and all were of European descent by self-report. The mean Angry Temperament and Angry Reaction scores were 5.8 ± 1.8 and 7.6 ± 2.2. We observed a nominally significant finding (p = 2.9E-08, λ = 1.027 - corrected pgc = 2.2E-07, λ = 1.0015) on chromosome 6q21 in the gene coding for the non-receptor protein-tyrosine kinase, Fyn.<h4>Conclusions</h4>Fyn interacts with NDMA receptors and inositol-1,4,5-trisphosphate (IP3)-gated channels to regulate calcium influx and intracellular release in the post-synaptic density. These results suggest that signaling pathways regulating intracellular calcium homeostasis, which are relevant to memory, learning, and neuronal survival, may in part underlie the expression of Angry Temperament.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0087257&type=printable |
| spellingShingle | Eric Mick James McGough Curtis K Deutsch Jean A Frazier David Kennedy Robert J Goldberg Genome-wide association study of proneness to anger. PLoS ONE |
| title | Genome-wide association study of proneness to anger. |
| title_full | Genome-wide association study of proneness to anger. |
| title_fullStr | Genome-wide association study of proneness to anger. |
| title_full_unstemmed | Genome-wide association study of proneness to anger. |
| title_short | Genome-wide association study of proneness to anger. |
| title_sort | genome wide association study of proneness to anger |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0087257&type=printable |
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