Advanced screen-printed electrode functionalized ZnO/CNTs for the electrochemical analysis of opioid drug pethidine co administered with paracetamol: application in dosage form and human plasma sample
Abstract Synthetic opioids such as pethidine (PTD) have a high potential for addiction but are widely used in clinical settings to manage pain before and after surgical procedures. Combinations of pethidine (PTD) with paracetamol (PCM) are frequently prescribed for the treatment of severe and chroni...
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| Format: | Article |
| Language: | English |
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BMC
2025-08-01
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| Series: | BMC Chemistry |
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| Online Access: | https://doi.org/10.1186/s13065-025-01599-8 |
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| author | Shimaa A. Atty Ahmed M. Abdelzaher Sona Barghash Mona A. Abdel Rahman |
| author_facet | Shimaa A. Atty Ahmed M. Abdelzaher Sona Barghash Mona A. Abdel Rahman |
| author_sort | Shimaa A. Atty |
| collection | DOAJ |
| description | Abstract Synthetic opioids such as pethidine (PTD) have a high potential for addiction but are widely used in clinical settings to manage pain before and after surgical procedures. Combinations of pethidine (PTD) with paracetamol (PCM) are frequently prescribed for the treatment of severe and chronic pain. In this study, an eco-friendly voltammetric sensor based on a screen-printed electrode (SPE) modified with zinc oxide nanoparticles functionalized with carbon nanotubes (ZnO/CNTs) was developed and employed. For the first time, the proposed sensor was successfully applied for the determination of pethidine in pharmaceutical formulations, demonstrating excellent recovery. Furthermore, it enabled the simultaneous detection of pethidine and paracetamol in biological samples, with low detection limits of 980 pmol L⁻1 and 977 pmol L⁻1 for PTD and PCM, respectively. The sensor offers a promising tool for point of care diagnostics and routine analysis due to its sensitivity, simplicity, and cost-effectiveness. |
| format | Article |
| id | doaj-art-d4458eebbaf746b0a86541f53db302ac |
| institution | Kabale University |
| issn | 2661-801X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Chemistry |
| spelling | doaj-art-d4458eebbaf746b0a86541f53db302ac2025-08-20T03:42:29ZengBMCBMC Chemistry2661-801X2025-08-0119111410.1186/s13065-025-01599-8Advanced screen-printed electrode functionalized ZnO/CNTs for the electrochemical analysis of opioid drug pethidine co administered with paracetamol: application in dosage form and human plasma sampleShimaa A. Atty0Ahmed M. Abdelzaher1Sona Barghash2Mona A. Abdel Rahman3Pharmaceutical Chemistry Department, Egyptian Drug AuthorityDepartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al-Azhar UniversityDepartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al-Azhar UniversityAnalytical Chemistry Department, Faculty of Pharmacy, October 6 UniversityAbstract Synthetic opioids such as pethidine (PTD) have a high potential for addiction but are widely used in clinical settings to manage pain before and after surgical procedures. Combinations of pethidine (PTD) with paracetamol (PCM) are frequently prescribed for the treatment of severe and chronic pain. In this study, an eco-friendly voltammetric sensor based on a screen-printed electrode (SPE) modified with zinc oxide nanoparticles functionalized with carbon nanotubes (ZnO/CNTs) was developed and employed. For the first time, the proposed sensor was successfully applied for the determination of pethidine in pharmaceutical formulations, demonstrating excellent recovery. Furthermore, it enabled the simultaneous detection of pethidine and paracetamol in biological samples, with low detection limits of 980 pmol L⁻1 and 977 pmol L⁻1 for PTD and PCM, respectively. The sensor offers a promising tool for point of care diagnostics and routine analysis due to its sensitivity, simplicity, and cost-effectiveness.https://doi.org/10.1186/s13065-025-01599-8Screen printed electrodeZnOMulti-walled carbon nanotubePethidineParacetamolPlasma |
| spellingShingle | Shimaa A. Atty Ahmed M. Abdelzaher Sona Barghash Mona A. Abdel Rahman Advanced screen-printed electrode functionalized ZnO/CNTs for the electrochemical analysis of opioid drug pethidine co administered with paracetamol: application in dosage form and human plasma sample BMC Chemistry Screen printed electrode ZnO Multi-walled carbon nanotube Pethidine Paracetamol Plasma |
| title | Advanced screen-printed electrode functionalized ZnO/CNTs for the electrochemical analysis of opioid drug pethidine co administered with paracetamol: application in dosage form and human plasma sample |
| title_full | Advanced screen-printed electrode functionalized ZnO/CNTs for the electrochemical analysis of opioid drug pethidine co administered with paracetamol: application in dosage form and human plasma sample |
| title_fullStr | Advanced screen-printed electrode functionalized ZnO/CNTs for the electrochemical analysis of opioid drug pethidine co administered with paracetamol: application in dosage form and human plasma sample |
| title_full_unstemmed | Advanced screen-printed electrode functionalized ZnO/CNTs for the electrochemical analysis of opioid drug pethidine co administered with paracetamol: application in dosage form and human plasma sample |
| title_short | Advanced screen-printed electrode functionalized ZnO/CNTs for the electrochemical analysis of opioid drug pethidine co administered with paracetamol: application in dosage form and human plasma sample |
| title_sort | advanced screen printed electrode functionalized zno cnts for the electrochemical analysis of opioid drug pethidine co administered with paracetamol application in dosage form and human plasma sample |
| topic | Screen printed electrode ZnO Multi-walled carbon nanotube Pethidine Paracetamol Plasma |
| url | https://doi.org/10.1186/s13065-025-01599-8 |
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