Retrospective and Prospective Surveillance and Clinical Presentation of Parvovirus B19 in Veneto, Italy, 2024
The recent increase in parvovirus B19 (B19V) infections across Europe has underscored the need for enhanced surveillance. In Italy, B19V surveillance is not mandated nationally. This ambispective (retrospective and prospective) study aimed to assess the epidemiological and clinical characteristics o...
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MDPI AG
2025-02-01
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| Online Access: | https://www.mdpi.com/2076-2607/13/2/430 |
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| author | Michele Tonon Stefan-Alexandru Panaite Davide Gentili Anna Ferraresso Filippo Da Re Debora Ballarin Francesca Zanella Maria Teresa Padovan Michela Pascarella Sara Mondino Flavia Riccardo Anna Teresa Palamara Nicola Cogo Marco Milani Michele Nicoletti Gloria Pagin Maria Silvia Varalta Andrea Cozza Romina Cazzaro Francesca Russo Vincenzo Baldo |
| author_facet | Michele Tonon Stefan-Alexandru Panaite Davide Gentili Anna Ferraresso Filippo Da Re Debora Ballarin Francesca Zanella Maria Teresa Padovan Michela Pascarella Sara Mondino Flavia Riccardo Anna Teresa Palamara Nicola Cogo Marco Milani Michele Nicoletti Gloria Pagin Maria Silvia Varalta Andrea Cozza Romina Cazzaro Francesca Russo Vincenzo Baldo |
| author_sort | Michele Tonon |
| collection | DOAJ |
| description | The recent increase in parvovirus B19 (B19V) infections across Europe has underscored the need for enhanced surveillance. In Italy, B19V surveillance is not mandated nationally. This ambispective (retrospective and prospective) study aimed to assess the epidemiological and clinical characteristics of the 2024 apparent surge in the Veneto Region by implementing mandatory disease notification starting in May 2024 and collecting clinical data on confirmed cases. During the surveillance period, 3156 B19V cases were reported, with 2.9% (93/3156) requiring hospitalisation (95% CI 2.4–3.5%). Children under 1 year of age exhibited the highest hospitalisation rate (29.0%), followed by adults aged 18–40 (17.5%). Infections disproportionately affected children aged 1–5 and 6–11, and the Granger causality test showed that an increase in cases among the 1–5-year-olds was predictive of subsequent rises in other age groups (<i>p</i> = 0.0086). Severe complications, including myocarditis, pericarditis, and miscarriage, were observed, and one death occurred following cardiac and neurological complications in a patient without prior risk factors. The presence of concurrent pathologies, particularly haematological disorders, was associated with increased disease severity. These findings highlight the importance of early warning when cases begin rising among preschool-aged children and underscore the need for improved B19V awareness, particularly in high-risk populations. Future efforts should evaluate the feasibility of implementing a systematic, potentially EU-wide, surveillance for B19V. |
| format | Article |
| id | doaj-art-d442e1c0453145e18edf89e6cfaaca7a |
| institution | DOAJ |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-d442e1c0453145e18edf89e6cfaaca7a2025-08-20T02:44:47ZengMDPI AGMicroorganisms2076-26072025-02-0113243010.3390/microorganisms13020430Retrospective and Prospective Surveillance and Clinical Presentation of Parvovirus B19 in Veneto, Italy, 2024Michele Tonon0Stefan-Alexandru Panaite1Davide Gentili2Anna Ferraresso3Filippo Da Re4Debora Ballarin5Francesca Zanella6Maria Teresa Padovan7Michela Pascarella8Sara Mondino9Flavia Riccardo10Anna Teresa Palamara11Nicola Cogo12Marco Milani13Michele Nicoletti14Gloria Pagin15Maria Silvia Varalta16Andrea Cozza17Romina Cazzaro18Francesca Russo19Vincenzo Baldo20Regional Directorate of Prevention, Food Safety, Veterinary Public Health, Regione del Veneto, 30123 Venice, ItalyDepartment of Cardiac Thoracic and Vascular Sciences, and Public Health, University of Padua, 35128 Padua, ItalyRegional Directorate of Prevention, Food Safety, Veterinary Public Health, Regione del Veneto, 30123 Venice, ItalyLocal Health Authority ULSS 8 Berica, 36100 Vicenza, ItalyRegional Directorate of Prevention, Food Safety, Veterinary Public Health, Regione del Veneto, 30123 Venice, ItalyRegional Directorate of Prevention, Food Safety, Veterinary Public Health, Regione del Veneto, 30123 Venice, ItalyRegional Directorate of Prevention, Food Safety, Veterinary Public Health, Regione del Veneto, 30123 Venice, ItalyLocal Health Authority ULSS 8 Berica, 36100 Vicenza, ItalyLocal Health Authority ULSS 8 Berica, 36100 Vicenza, ItalyLocal Health Authority ULSS 8 Berica, 36100 Vicenza, ItalyDepartment of Infectious Diseases, National Health Institute (Istituto Superiore di Sanità), 00161 Rome, ItalyDepartment of Infectious Diseases, National Health Institute (Istituto Superiore di Sanità), 00161 Rome, ItalyDepartment of Cardiac Thoracic and Vascular Sciences, and Public Health, University of Padua, 35128 Padua, ItalyDepartment of Cardiac Thoracic and Vascular Sciences, and Public Health, University of Padua, 35128 Padua, ItalyDepartment of Cardiac Thoracic and Vascular Sciences, and Public Health, University of Padua, 35128 Padua, ItalyRegional Directorate of Prevention, Food Safety, Veterinary Public Health, Regione del Veneto, 30123 Venice, ItalyRegional Directorate for Health Planning, Regione del Veneto, 30125 Venice, ItalyDepartment of Cardiac Thoracic and Vascular Sciences, and Public Health, University of Padua, 35128 Padua, ItalyRegional Directorate for Health Planning, Regione del Veneto, 30125 Venice, ItalyRegional Directorate of Prevention, Food Safety, Veterinary Public Health, Regione del Veneto, 30123 Venice, ItalyDepartment of Cardiac Thoracic and Vascular Sciences, and Public Health, University of Padua, 35128 Padua, ItalyThe recent increase in parvovirus B19 (B19V) infections across Europe has underscored the need for enhanced surveillance. In Italy, B19V surveillance is not mandated nationally. This ambispective (retrospective and prospective) study aimed to assess the epidemiological and clinical characteristics of the 2024 apparent surge in the Veneto Region by implementing mandatory disease notification starting in May 2024 and collecting clinical data on confirmed cases. During the surveillance period, 3156 B19V cases were reported, with 2.9% (93/3156) requiring hospitalisation (95% CI 2.4–3.5%). Children under 1 year of age exhibited the highest hospitalisation rate (29.0%), followed by adults aged 18–40 (17.5%). Infections disproportionately affected children aged 1–5 and 6–11, and the Granger causality test showed that an increase in cases among the 1–5-year-olds was predictive of subsequent rises in other age groups (<i>p</i> = 0.0086). Severe complications, including myocarditis, pericarditis, and miscarriage, were observed, and one death occurred following cardiac and neurological complications in a patient without prior risk factors. The presence of concurrent pathologies, particularly haematological disorders, was associated with increased disease severity. These findings highlight the importance of early warning when cases begin rising among preschool-aged children and underscore the need for improved B19V awareness, particularly in high-risk populations. Future efforts should evaluate the feasibility of implementing a systematic, potentially EU-wide, surveillance for B19V.https://www.mdpi.com/2076-2607/13/2/430parvovirus B19myocarditisinfectious disease surveillanceclinical presentationepidemiologycomorbidities |
| spellingShingle | Michele Tonon Stefan-Alexandru Panaite Davide Gentili Anna Ferraresso Filippo Da Re Debora Ballarin Francesca Zanella Maria Teresa Padovan Michela Pascarella Sara Mondino Flavia Riccardo Anna Teresa Palamara Nicola Cogo Marco Milani Michele Nicoletti Gloria Pagin Maria Silvia Varalta Andrea Cozza Romina Cazzaro Francesca Russo Vincenzo Baldo Retrospective and Prospective Surveillance and Clinical Presentation of Parvovirus B19 in Veneto, Italy, 2024 Microorganisms parvovirus B19 myocarditis infectious disease surveillance clinical presentation epidemiology comorbidities |
| title | Retrospective and Prospective Surveillance and Clinical Presentation of Parvovirus B19 in Veneto, Italy, 2024 |
| title_full | Retrospective and Prospective Surveillance and Clinical Presentation of Parvovirus B19 in Veneto, Italy, 2024 |
| title_fullStr | Retrospective and Prospective Surveillance and Clinical Presentation of Parvovirus B19 in Veneto, Italy, 2024 |
| title_full_unstemmed | Retrospective and Prospective Surveillance and Clinical Presentation of Parvovirus B19 in Veneto, Italy, 2024 |
| title_short | Retrospective and Prospective Surveillance and Clinical Presentation of Parvovirus B19 in Veneto, Italy, 2024 |
| title_sort | retrospective and prospective surveillance and clinical presentation of parvovirus b19 in veneto italy 2024 |
| topic | parvovirus B19 myocarditis infectious disease surveillance clinical presentation epidemiology comorbidities |
| url | https://www.mdpi.com/2076-2607/13/2/430 |
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