Fatty acid addition strategy redirected the metabolic flux towards an ultra-high monensin productivity of Streptomyces cinnamonensis

Fatty acid addition strategy redirected the metabolic flux towards an ultra-high monensin productivity of Streptomyces cinnamonensis

Monensin, a polyether ionophore antibiotic produced by Streptomyces cinnamonensis, exhibits notable anticoccidial and antitumor properties. In this study, a fatty acid addition (FAA) strategy significantly enhanced the monensin production capability of S. cinnamonensis, resulting in an unprecedented...

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Bibliographic Details
Main Authors: Shanfei Zhang, Qingming Hou, Zhenhua Wang, Dandan Tian, Xianyuan Zhang, Yan Zhang, Qun Wu, Fubao Sun
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-06-01
Series:Synthetic and Systems Biotechnology
Subjects:
Carbon flux redirection
Fatty acid
Secondary metabolites
Polyketide
Streptomyces cinnamonensis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X25000171
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