Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1.

Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1.

Loss of the tumor suppressor Pdcd4 was reported for various tumor entities and proposed as a prognostic marker in tumorigenesis. We previously characterized decreased Pdcd4 protein stability in response to mitogenic stimuli, which resulted from p70(S6K1)-dependent protein phosphorylation, β-TrCP1-me...

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Main Authors: Johanna S Blees, Heidi R Bokesch, Daniela Rübsamen, Kathrin Schulz, Larissa Milke, Magdalena M Bajer, Kirk R Gustafson, Curtis J Henrich, James B McMahon, Nancy H Colburn, Tobias Schmid, Bernhard Brüne
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0046567&type=printable
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