Placement of an elastic, biohybrid patch in a model of right heart failure with pulmonary artery banding
IntroductionIn a model of right heart failure secondary to pulmonary artery banding (PAB), a mechanical approach using an elastic, biodegradable epicardial patch with integrated extracellular matrix digest was evaluated for its potential to inhibit disease progression.MethodsAdult male syngeneic Lew...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1485740/full |
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| author | Yasunari Hayashi Yasunari Hayashi Seungil Kim Seungil Kim Seungil Kim Taro Fujii Taro Fujii Drake Dalton Pedersen Drake Dalton Pedersen Takahiro Ozeki Takahiro Ozeki Hongbin Jiang Antonio D’Amore Antonio D’Amore Antonio D’Amore Antonio D’Amore Antonio D’Amore William R. Wagner William R. Wagner William R. Wagner |
| author_facet | Yasunari Hayashi Yasunari Hayashi Seungil Kim Seungil Kim Seungil Kim Taro Fujii Taro Fujii Drake Dalton Pedersen Drake Dalton Pedersen Takahiro Ozeki Takahiro Ozeki Hongbin Jiang Antonio D’Amore Antonio D’Amore Antonio D’Amore Antonio D’Amore Antonio D’Amore William R. Wagner William R. Wagner William R. Wagner |
| author_sort | Yasunari Hayashi |
| collection | DOAJ |
| description | IntroductionIn a model of right heart failure secondary to pulmonary artery banding (PAB), a mechanical approach using an elastic, biodegradable epicardial patch with integrated extracellular matrix digest was evaluated for its potential to inhibit disease progression.MethodsAdult male syngeneic Lewis rats aged 6–7 weeks old were used. Biohybrid cardiac patches were generated by co-processing biodegradable poly(ester carbonate urethane) urea (PECUU) and a digest of the porcine cardiac extracellular matrix. Three weeks after PAB, the cardiac patch was attached to the epicardium of the right ventricle (RV). Cardiac function was evaluated using echocardiography and catheterization for 9 weeks after PAB, comparing the patch (n = 7) and sham (n = 10) groups.ResultsNine weeks after PAB, the RV wall was thickened, the RV cavity was enlarged with a reduced left ventricular cavity, and RV wall interstitial fibrosis was increased. However, these effects were diminished in the patch group. Left ventricular ejection fraction in the patch group was higher than in the sham group (p < 0.001), right end-systolic pressure was lower (p = 0.045), and tricuspid annular plane systolic excursion improved in the patch group (p = 0.007). In addition, von Willebrand factor expression was significantly greater in the patch group (p = 0.007).ConclusionsThe placement of a degradable, biohybrid patch onto the RV in a right ventricular failure model with fixed afterload improved myocardial output, moderated pressure stress, and was associated with reduced right ventricular fibrosis. |
| format | Article |
| id | doaj-art-d4385e61d5d54c34acfa9db38805b3d7 |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-d4385e61d5d54c34acfa9db38805b3d72025-01-20T09:54:57ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-01-011210.3389/fbioe.2024.14857401485740Placement of an elastic, biohybrid patch in a model of right heart failure with pulmonary artery bandingYasunari Hayashi0Yasunari Hayashi1Seungil Kim2Seungil Kim3Seungil Kim4Taro Fujii5Taro Fujii6Drake Dalton Pedersen7Drake Dalton Pedersen8Takahiro Ozeki9Takahiro Ozeki10Hongbin Jiang11Antonio D’Amore12Antonio D’Amore13Antonio D’Amore14Antonio D’Amore15Antonio D’Amore16William R. Wagner17William R. Wagner18William R. Wagner19McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, United StatesMcGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Agricultural and Biological Engineering, Mississippi State University, Mississippi State, MS, United StatesMcGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, United StatesMcGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United StatesMcGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, United StatesMcGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United StatesMcGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United StatesFondazione RiMED, Palermo, ItalyMedicina di Precisione in Area Medica, Chirurgica e Critica, University of Palermo, Palermo, ItalyMcGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United StatesIntroductionIn a model of right heart failure secondary to pulmonary artery banding (PAB), a mechanical approach using an elastic, biodegradable epicardial patch with integrated extracellular matrix digest was evaluated for its potential to inhibit disease progression.MethodsAdult male syngeneic Lewis rats aged 6–7 weeks old were used. Biohybrid cardiac patches were generated by co-processing biodegradable poly(ester carbonate urethane) urea (PECUU) and a digest of the porcine cardiac extracellular matrix. Three weeks after PAB, the cardiac patch was attached to the epicardium of the right ventricle (RV). Cardiac function was evaluated using echocardiography and catheterization for 9 weeks after PAB, comparing the patch (n = 7) and sham (n = 10) groups.ResultsNine weeks after PAB, the RV wall was thickened, the RV cavity was enlarged with a reduced left ventricular cavity, and RV wall interstitial fibrosis was increased. However, these effects were diminished in the patch group. Left ventricular ejection fraction in the patch group was higher than in the sham group (p < 0.001), right end-systolic pressure was lower (p = 0.045), and tricuspid annular plane systolic excursion improved in the patch group (p = 0.007). In addition, von Willebrand factor expression was significantly greater in the patch group (p = 0.007).ConclusionsThe placement of a degradable, biohybrid patch onto the RV in a right ventricular failure model with fixed afterload improved myocardial output, moderated pressure stress, and was associated with reduced right ventricular fibrosis.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1485740/fullright heart failurepulmonary artery bandingright ventricular hypertrophycardiac extracellular matrixcardiac patch |
| spellingShingle | Yasunari Hayashi Yasunari Hayashi Seungil Kim Seungil Kim Seungil Kim Taro Fujii Taro Fujii Drake Dalton Pedersen Drake Dalton Pedersen Takahiro Ozeki Takahiro Ozeki Hongbin Jiang Antonio D’Amore Antonio D’Amore Antonio D’Amore Antonio D’Amore Antonio D’Amore William R. Wagner William R. Wagner William R. Wagner Placement of an elastic, biohybrid patch in a model of right heart failure with pulmonary artery banding Frontiers in Bioengineering and Biotechnology right heart failure pulmonary artery banding right ventricular hypertrophy cardiac extracellular matrix cardiac patch |
| title | Placement of an elastic, biohybrid patch in a model of right heart failure with pulmonary artery banding |
| title_full | Placement of an elastic, biohybrid patch in a model of right heart failure with pulmonary artery banding |
| title_fullStr | Placement of an elastic, biohybrid patch in a model of right heart failure with pulmonary artery banding |
| title_full_unstemmed | Placement of an elastic, biohybrid patch in a model of right heart failure with pulmonary artery banding |
| title_short | Placement of an elastic, biohybrid patch in a model of right heart failure with pulmonary artery banding |
| title_sort | placement of an elastic biohybrid patch in a model of right heart failure with pulmonary artery banding |
| topic | right heart failure pulmonary artery banding right ventricular hypertrophy cardiac extracellular matrix cardiac patch |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1485740/full |
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