A Case of Severe Seronegative Inflammatory Arthritis due to Nivolumab and Review of the Literature
Immune-checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer, yet therapy is often hampered by immune-related adverse events (irAEs) which range from mild to severe life-threatening events. Musculoskeletal (MSK) irAEs leading to discontinuation of ICIs are uncommon but increasingl...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2019/1326734 |
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| _version_ | 1850173874535137280 |
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| author | Bicky Thapa Asad Ali Raunak Nair Rishik Vashisht Cassandra Calabrese |
| author_facet | Bicky Thapa Asad Ali Raunak Nair Rishik Vashisht Cassandra Calabrese |
| author_sort | Bicky Thapa |
| collection | DOAJ |
| description | Immune-checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer, yet therapy is often hampered by immune-related adverse events (irAEs) which range from mild to severe life-threatening events. Musculoskeletal (MSK) irAEs leading to discontinuation of ICIs are uncommon but increasingly recognized. We report a challenging case of severe immune-related seronegative inflammatory arthritis due to nivolumab in a patient with stage IV metastatic adenocarcinoma. |
| format | Article |
| id | doaj-art-d43795176f1b4ca18283291c7014bb13 |
| institution | OA Journals |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-d43795176f1b4ca18283291c7014bb132025-08-20T02:19:45ZengWileyCase Reports in Rheumatology2090-68892090-68972019-01-01201910.1155/2019/13267341326734A Case of Severe Seronegative Inflammatory Arthritis due to Nivolumab and Review of the LiteratureBicky Thapa0Asad Ali1Raunak Nair2Rishik Vashisht3Cassandra Calabrese4Department of Internal Medicine, Cleveland Clinic Fairview Hospital, Cleveland, Ohio, USANeurological Institute, Taussig Center Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USADepartment of Internal Medicine, Cleveland Clinic Fairview Hospital, Cleveland, Ohio, USARespiratory Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USADepartment of Rheumatic & Immunologic Disease, Cleveland Clinic Foundation, Cleveland, Ohio, USAImmune-checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer, yet therapy is often hampered by immune-related adverse events (irAEs) which range from mild to severe life-threatening events. Musculoskeletal (MSK) irAEs leading to discontinuation of ICIs are uncommon but increasingly recognized. We report a challenging case of severe immune-related seronegative inflammatory arthritis due to nivolumab in a patient with stage IV metastatic adenocarcinoma.http://dx.doi.org/10.1155/2019/1326734 |
| spellingShingle | Bicky Thapa Asad Ali Raunak Nair Rishik Vashisht Cassandra Calabrese A Case of Severe Seronegative Inflammatory Arthritis due to Nivolumab and Review of the Literature Case Reports in Rheumatology |
| title | A Case of Severe Seronegative Inflammatory Arthritis due to Nivolumab and Review of the Literature |
| title_full | A Case of Severe Seronegative Inflammatory Arthritis due to Nivolumab and Review of the Literature |
| title_fullStr | A Case of Severe Seronegative Inflammatory Arthritis due to Nivolumab and Review of the Literature |
| title_full_unstemmed | A Case of Severe Seronegative Inflammatory Arthritis due to Nivolumab and Review of the Literature |
| title_short | A Case of Severe Seronegative Inflammatory Arthritis due to Nivolumab and Review of the Literature |
| title_sort | case of severe seronegative inflammatory arthritis due to nivolumab and review of the literature |
| url | http://dx.doi.org/10.1155/2019/1326734 |
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