Glutathione system participation on neutrophils functional status during acute inflammation
There was conducted the study of glutathione system status (the content of reduced, oxidized, protein-bound glutathione, SHgroups of proteins and glutathionperoxydase activity) and functional properties (the production of hydroxyl radical, IL-8, TNF-α and myeloperoxidase activity) of neutrophils rec...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Siberian State Medical University (Tomsk)
2010-10-01
|
| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/1654 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | There was conducted the study of glutathione system status (the content of reduced, oxidized, protein-bound glutathione, SHgroups of proteins and glutathionperoxydase activity) and functional properties (the production of hydroxyl radical, IL-8, TNF-α and myeloperoxidase activity) of neutrophils received from people with community-acquired pneumonia. There was revealed the role of reduced and protein-bound glutathione in the regulation of myeloperoxidase activity and production of hydroxyl radical by blood neutrophils when incubating cells with glutathione synthesis blocker de novo (buthioninesulfoximine). and catalase inhibitor (3-amino-1,2,4-triazole). It was ascertained that glutathione synthesis de novo is more important than catalase activity (inhibition by 3-amino 1,2,4-triasole) to support neutrophil functional condition. |
|---|---|
| ISSN: | 1682-0363 1819-3684 |