Commercial chip-based tunneling magnetoresistance sensor for green-synthesized magnetic nanoparticles assay
Owing to their significant roles in multiple sectors, the demand for high-performance, rapid, user-friendly, and low-cost sensors is crucial for biosensing. This paper reports the performance of a commercial chip-based tunneling magnetoresistance (TMR) sensor for detecting green-synthesized magnetic...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-01-01
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| Series: | Sensors International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266635112400010X |
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| author | Pinaka Elda Swastika Harlina Ardiyanti Zurnansyah Deska Lismawenning Puspitarum Nurul Imani Istiqomah Nur Aji Wibowo Edi Suharyadi |
| author_facet | Pinaka Elda Swastika Harlina Ardiyanti Zurnansyah Deska Lismawenning Puspitarum Nurul Imani Istiqomah Nur Aji Wibowo Edi Suharyadi |
| author_sort | Pinaka Elda Swastika |
| collection | DOAJ |
| description | Owing to their significant roles in multiple sectors, the demand for high-performance, rapid, user-friendly, and low-cost sensors is crucial for biosensing. This paper reports the performance of a commercial chip-based tunneling magnetoresistance (TMR) sensor for detecting green-synthesized magnetic nanoparticles (MNP) as potential magnetic labels. A Simple and low-cost design consisting of a TMR chip ALT-025 integrated with an Arduino microcontroller and a basic differential amplifier was developed to provide real-time and measurable digital readouts. Three kinds of ferrite MNPs (Fe3O4, CoFe2O4 and MnFe2O4) was synthesized by the coprecipitation method on the green synthesis approach utilizing Moringa Oleifera extracts. All sample have a face-centered cubic inverse spinel structure with average grain size of 10.3 nm, 9.2 nm and 6.1 nm for Fe3O4, CoFe2O4 and MnFe2O4, respectively. Furthermore, soft ferromagnetic behavior is identified for all sample with magnetization saturation of 55.3 emu/g, 37.6 emu/g, 19.3 emu/g for Fe3O4, CoFe2O4 and MnFe2O4, respectively. The sensor showed a promising performance in the detection of MNPs. For the three particles, the sensitivity exhibited a linear function of the MNPs concentration. The sensitivity is related not only to the particle size but also to the magnetization of the nanoparticles in the bias field. The change in the output voltage was proportional to the bias magnetization (MBias), indicating that particles with a higher bias magnetization can produce a stronger magnetic stray field on the TMR sensor surface. The sensor system successfully detected MNPs at different stray field intensities. Furthermore, a low limit of detection was achieved using these methods. Moreover, the remarkable stability and repeatability of the sensor is further validated by the steady signal acquired for 30s with an RSD of 0.5–28.5 %. Therefore, the integration of commercial chip-based TMR sensors and green-synthesized MNPs has great potential for advancing the detection of various biomolecules. |
| format | Article |
| id | doaj-art-d4322810f6f64a318719e8c02f150db1 |
| institution | DOAJ |
| issn | 2666-3511 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Sensors International |
| spelling | doaj-art-d4322810f6f64a318719e8c02f150db12025-08-20T02:46:04ZengKeAi Communications Co., Ltd.Sensors International2666-35112024-01-01510028810.1016/j.sintl.2024.100288Commercial chip-based tunneling magnetoresistance sensor for green-synthesized magnetic nanoparticles assayPinaka Elda Swastika0Harlina Ardiyanti1 Zurnansyah2Deska Lismawenning Puspitarum3Nurul Imani Istiqomah4Nur Aji Wibowo5Edi Suharyadi6Department of Physics, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Physics Education, Universitas Negeri Yogyakarta, Yogyakarta, IndonesiaDepartment of Physics, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Physics, Institut Teknologi Sumatera, Lampung, IndonesiaDepartment of Physics, Universitas Gadjah Mada, Yogyakarta, IndonesiaDepartment of Physics, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Physics, Institut Teknologi Sumatera, Lampung, IndonesiaDepartment of Physics, Universitas Gadjah Mada, Yogyakarta, IndonesiaDepartment of Physics, Universitas Kristen Satya Wacana, Salatiga, IndonesiaDepartment of Physics, Universitas Gadjah Mada, Yogyakarta, Indonesia; Corresponding author.Owing to their significant roles in multiple sectors, the demand for high-performance, rapid, user-friendly, and low-cost sensors is crucial for biosensing. This paper reports the performance of a commercial chip-based tunneling magnetoresistance (TMR) sensor for detecting green-synthesized magnetic nanoparticles (MNP) as potential magnetic labels. A Simple and low-cost design consisting of a TMR chip ALT-025 integrated with an Arduino microcontroller and a basic differential amplifier was developed to provide real-time and measurable digital readouts. Three kinds of ferrite MNPs (Fe3O4, CoFe2O4 and MnFe2O4) was synthesized by the coprecipitation method on the green synthesis approach utilizing Moringa Oleifera extracts. All sample have a face-centered cubic inverse spinel structure with average grain size of 10.3 nm, 9.2 nm and 6.1 nm for Fe3O4, CoFe2O4 and MnFe2O4, respectively. Furthermore, soft ferromagnetic behavior is identified for all sample with magnetization saturation of 55.3 emu/g, 37.6 emu/g, 19.3 emu/g for Fe3O4, CoFe2O4 and MnFe2O4, respectively. The sensor showed a promising performance in the detection of MNPs. For the three particles, the sensitivity exhibited a linear function of the MNPs concentration. The sensitivity is related not only to the particle size but also to the magnetization of the nanoparticles in the bias field. The change in the output voltage was proportional to the bias magnetization (MBias), indicating that particles with a higher bias magnetization can produce a stronger magnetic stray field on the TMR sensor surface. The sensor system successfully detected MNPs at different stray field intensities. Furthermore, a low limit of detection was achieved using these methods. Moreover, the remarkable stability and repeatability of the sensor is further validated by the steady signal acquired for 30s with an RSD of 0.5–28.5 %. Therefore, the integration of commercial chip-based TMR sensors and green-synthesized MNPs has great potential for advancing the detection of various biomolecules.http://www.sciencedirect.com/science/article/pii/S266635112400010XSensorTunneling magnetoresistanceCommercial chipGreen synthesisFerrite nanoparticles |
| spellingShingle | Pinaka Elda Swastika Harlina Ardiyanti Zurnansyah Deska Lismawenning Puspitarum Nurul Imani Istiqomah Nur Aji Wibowo Edi Suharyadi Commercial chip-based tunneling magnetoresistance sensor for green-synthesized magnetic nanoparticles assay Sensors International Sensor Tunneling magnetoresistance Commercial chip Green synthesis Ferrite nanoparticles |
| title | Commercial chip-based tunneling magnetoresistance sensor for green-synthesized magnetic nanoparticles assay |
| title_full | Commercial chip-based tunneling magnetoresistance sensor for green-synthesized magnetic nanoparticles assay |
| title_fullStr | Commercial chip-based tunneling magnetoresistance sensor for green-synthesized magnetic nanoparticles assay |
| title_full_unstemmed | Commercial chip-based tunneling magnetoresistance sensor for green-synthesized magnetic nanoparticles assay |
| title_short | Commercial chip-based tunneling magnetoresistance sensor for green-synthesized magnetic nanoparticles assay |
| title_sort | commercial chip based tunneling magnetoresistance sensor for green synthesized magnetic nanoparticles assay |
| topic | Sensor Tunneling magnetoresistance Commercial chip Green synthesis Ferrite nanoparticles |
| url | http://www.sciencedirect.com/science/article/pii/S266635112400010X |
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