Allogeneic bone marrow transplantation for children with myelodysplastic syndrome
Six children with myelodysplastic syndrome underwent allogeneic bone marrow transplantation (BMT) from their HLA-identical siblings. Ages ranged from six to 16 years. French-American British (FAB) diagnosis was refractory anemia with excess blasts (RAEB) in three, RAEB in transformation (RAEB...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2000-07-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/3132 |
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| _version_ | 1850033429607874560 |
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| author | D Uçkan M Cetin G Hiçsönmez I Tezcan A M Tuncer |
| author_facet | D Uçkan M Cetin G Hiçsönmez I Tezcan A M Tuncer |
| author_sort | D Uçkan |
| collection | DOAJ |
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Six children with myelodysplastic syndrome underwent allogeneic bone marrow transplantation (BMT) from their HLA-identical siblings. Ages ranged from six to 16 years. French-American British (FAB) diagnosis was refractory anemia with excess blasts (RAEB) in three, RAEB in transformation (RAEB-t) in one and chronic myelomonocytic leukemia (CMML) in two cases. Two patients had progressed to leukemia before BMT. All patients received busulfan and cyclophosphamide as a conditioning regimen. Antithymocyte globulin (ATG) was administered to two of them due to the multiple transfusion history. Graft versus host disease (GvHD) prophylaxis consisted of cyclosporine-methotrexate. Engraftment was documented in all patients except one who underwent a second infusion of bone marrow cells. She died in the early post-transplant period with pancytopenia and veno-occlusive disease of the liver. Two patients died from disease recurrence. Three patients are alive > 12 months post-transplant, two are in remission and one just relapsed at +16 months and is now being prepared for a second bone marrow transplant. The only significant factor for favorable outcome was short duration between diagnosis to transplant in the two patients in remission.
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| format | Article |
| id | doaj-art-d427fcaa2adc4be1adc33df996c1cb8b |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2000-07-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-d427fcaa2adc4be1adc33df996c1cb8b2025-08-20T02:58:14ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212000-07-01423Allogeneic bone marrow transplantation for children with myelodysplastic syndromeD Uçkan0M CetinG HiçsönmezI TezcanA M TuncerUnit of Bone Marrow Transplantation, Hacettepe University Faculty of Medicine, Ankara, Turkey. Six children with myelodysplastic syndrome underwent allogeneic bone marrow transplantation (BMT) from their HLA-identical siblings. Ages ranged from six to 16 years. French-American British (FAB) diagnosis was refractory anemia with excess blasts (RAEB) in three, RAEB in transformation (RAEB-t) in one and chronic myelomonocytic leukemia (CMML) in two cases. Two patients had progressed to leukemia before BMT. All patients received busulfan and cyclophosphamide as a conditioning regimen. Antithymocyte globulin (ATG) was administered to two of them due to the multiple transfusion history. Graft versus host disease (GvHD) prophylaxis consisted of cyclosporine-methotrexate. Engraftment was documented in all patients except one who underwent a second infusion of bone marrow cells. She died in the early post-transplant period with pancytopenia and veno-occlusive disease of the liver. Two patients died from disease recurrence. Three patients are alive > 12 months post-transplant, two are in remission and one just relapsed at +16 months and is now being prepared for a second bone marrow transplant. The only significant factor for favorable outcome was short duration between diagnosis to transplant in the two patients in remission. https://turkjpediatr.org/article/view/3132 |
| spellingShingle | D Uçkan M Cetin G Hiçsönmez I Tezcan A M Tuncer Allogeneic bone marrow transplantation for children with myelodysplastic syndrome The Turkish Journal of Pediatrics |
| title | Allogeneic bone marrow transplantation for children with myelodysplastic syndrome |
| title_full | Allogeneic bone marrow transplantation for children with myelodysplastic syndrome |
| title_fullStr | Allogeneic bone marrow transplantation for children with myelodysplastic syndrome |
| title_full_unstemmed | Allogeneic bone marrow transplantation for children with myelodysplastic syndrome |
| title_short | Allogeneic bone marrow transplantation for children with myelodysplastic syndrome |
| title_sort | allogeneic bone marrow transplantation for children with myelodysplastic syndrome |
| url | https://turkjpediatr.org/article/view/3132 |
| work_keys_str_mv | AT duckan allogeneicbonemarrowtransplantationforchildrenwithmyelodysplasticsyndrome AT mcetin allogeneicbonemarrowtransplantationforchildrenwithmyelodysplasticsyndrome AT ghicsonmez allogeneicbonemarrowtransplantationforchildrenwithmyelodysplasticsyndrome AT itezcan allogeneicbonemarrowtransplantationforchildrenwithmyelodysplasticsyndrome AT amtuncer allogeneicbonemarrowtransplantationforchildrenwithmyelodysplasticsyndrome |