Berberine: a comprehensive Approach to combat human maladies
Berberine is a metabolite of many medicinal plants. Chemically, berberine belongs to the isoquinoline alkaloids family. The roots of plants grown at lower elevations have a higher concentration of berberine as compared to plants grown at higher elevations. Berberine is a natural substance, which is...
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Taylor & Francis Group
2023-09-01
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| Series: | International Journal of Food Properties |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10942912.2023.2184300 |
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| author | Zarina Mushtaq Muhammad Imran Farhan Saeed Ali Imran Shinawar Waseem Ali Muhammad Shahbaz Suliman A. Alsagaby Yolanda Guerrero Sánchez Maryam Umar Muzzamal Hussain Waleed Al Abdulmonem Entessar Al Jbawi Mahwish Ahmed H. El-Ghorab Mohamed A. Abdelgawad |
| author_facet | Zarina Mushtaq Muhammad Imran Farhan Saeed Ali Imran Shinawar Waseem Ali Muhammad Shahbaz Suliman A. Alsagaby Yolanda Guerrero Sánchez Maryam Umar Muzzamal Hussain Waleed Al Abdulmonem Entessar Al Jbawi Mahwish Ahmed H. El-Ghorab Mohamed A. Abdelgawad |
| author_sort | Zarina Mushtaq |
| collection | DOAJ |
| description | Berberine is a metabolite of many medicinal plants. Chemically, berberine belongs to the isoquinoline alkaloids family. The roots of plants grown at lower elevations have a higher concentration of berberine as compared to plants grown at higher elevations. Berberine is a natural substance, which is now among the patent pharmaceuticals for reducing chronic disorders and malignancies. Berberine is also classified as a nutraceutical. Nutraceuticals have been associated with various health benefits via modifying microRNA (miR) expression systems, apoptosis, gene activity, chemical signals/pathways and activation of transcription factors thus aiding in the prevention from various ailments. The pharmacokinetic studies revealed that berberine is poorly absorbed via intestinal walls therefore, its concentration level is extremely low in body fluid. However, the quantity of berberine and its active derivatives in organs is higher as compared to blood as it stably present in tissues. Berberine has an effective role in the body as an anticancer, antidiabetic, antiobesity, antioxidant, antiinflammatory, neuroprotective, hepatoprotective, antiaging and cardioprotective agent. In this review, the therapeutic potentials of berberine are discussed to understand its nutraceutical importance. |
| format | Article |
| id | doaj-art-d420daead2f94460b7b2f3de932f4f96 |
| institution | Kabale University |
| issn | 1094-2912 1532-2386 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Food Properties |
| spelling | doaj-art-d420daead2f94460b7b2f3de932f4f962025-01-02T10:41:34ZengTaylor & Francis GroupInternational Journal of Food Properties1094-29121532-23862023-09-0126178780710.1080/10942912.2023.2184300Berberine: a comprehensive Approach to combat human maladiesZarina Mushtaq0Muhammad Imran1Farhan Saeed2Ali Imran3Shinawar Waseem Ali4Muhammad Shahbaz5Suliman A. Alsagaby6Yolanda Guerrero Sánchez7Maryam Umar8Muzzamal Hussain9Waleed Al Abdulmonem10Entessar Al Jbawi11Mahwish12Ahmed H. El-Ghorab13Mohamed A. Abdelgawad14Department of Food Sciences, Government College University Faisalabad, PakistanDepartment of Food Science and Technology, University of Narowal-Pakistan, PakistanDepartment of Food Sciences, Government College University Faisalabad, PakistanDepartment of Food Sciences, Government College University Faisalabad, PakistanInstitute of Agricultural Sciences, University of the Punjab, Quid-i-Azam Campus, Lahore, PakistanDepartment of Food Science and Technology, MNS-University Multan, PakistanDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al-Majmaah, Saudi ArabiaDepartment of Human Anatomy and Psychobiology, University of Murcia, Murcia, SpainDepartment of Food Sciences, Government College University Faisalabad, PakistanDepartment of Food Sciences, Government College University Faisalabad, PakistanDepartment of Pathology, College of Medicine, Qassim University, Buraidah, Saudi ArabiaAgricultural Extension Directorate, MAAR, Damascus, SyriaDepartment of Nutritional Sciences, Government College Women University Faisalabad, PakistanDepartment of Chemistry, College of Science, Jouf University, Sakaka, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi ArabiaBerberine is a metabolite of many medicinal plants. Chemically, berberine belongs to the isoquinoline alkaloids family. The roots of plants grown at lower elevations have a higher concentration of berberine as compared to plants grown at higher elevations. Berberine is a natural substance, which is now among the patent pharmaceuticals for reducing chronic disorders and malignancies. Berberine is also classified as a nutraceutical. Nutraceuticals have been associated with various health benefits via modifying microRNA (miR) expression systems, apoptosis, gene activity, chemical signals/pathways and activation of transcription factors thus aiding in the prevention from various ailments. The pharmacokinetic studies revealed that berberine is poorly absorbed via intestinal walls therefore, its concentration level is extremely low in body fluid. However, the quantity of berberine and its active derivatives in organs is higher as compared to blood as it stably present in tissues. Berberine has an effective role in the body as an anticancer, antidiabetic, antiobesity, antioxidant, antiinflammatory, neuroprotective, hepatoprotective, antiaging and cardioprotective agent. In this review, the therapeutic potentials of berberine are discussed to understand its nutraceutical importance.https://www.tandfonline.com/doi/10.1080/10942912.2023.2184300BerberinePhytochemicalsCancer insurgenceMolecular pathwayDiabetes |
| spellingShingle | Zarina Mushtaq Muhammad Imran Farhan Saeed Ali Imran Shinawar Waseem Ali Muhammad Shahbaz Suliman A. Alsagaby Yolanda Guerrero Sánchez Maryam Umar Muzzamal Hussain Waleed Al Abdulmonem Entessar Al Jbawi Mahwish Ahmed H. El-Ghorab Mohamed A. Abdelgawad Berberine: a comprehensive Approach to combat human maladies International Journal of Food Properties Berberine Phytochemicals Cancer insurgence Molecular pathway Diabetes |
| title | Berberine: a comprehensive Approach to combat human maladies |
| title_full | Berberine: a comprehensive Approach to combat human maladies |
| title_fullStr | Berberine: a comprehensive Approach to combat human maladies |
| title_full_unstemmed | Berberine: a comprehensive Approach to combat human maladies |
| title_short | Berberine: a comprehensive Approach to combat human maladies |
| title_sort | berberine a comprehensive approach to combat human maladies |
| topic | Berberine Phytochemicals Cancer insurgence Molecular pathway Diabetes |
| url | https://www.tandfonline.com/doi/10.1080/10942912.2023.2184300 |
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