Synthesis, confirmations and biological evaluation of acid substituted Schiff base Derivatives: Unraveling insight through SAR, DFT, ADMET and molecular docking

Synthesis, confirmations and biological evaluation of acid substituted Schiff base Derivatives: Unraveling insight through SAR, DFT, ADMET and molecular docking

In this study we have adopted a new synthetic route for different substituted Schiff base derivatives (1–10) and examined their anti-diabetic potential. All these compounds exhibited a varied range against α-amylase and α-glucosidase with antidiabetic potential. Analog (6) with triflouro methyl subs...

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Bibliographic Details
Main Authors: Zaineb Amjid, Shoaib Khan, Tayyiaba Iqbal, Rafaqat Hussain, Hafeeza Zafar Ali, Khurram Shoaib, Yousaf Khan, Hayat Ullah, Sabeen Arshad, Rashid Iqbal, Riaz Ullah, Essam A. Ali
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Results in Chemistry
Subjects:
ADME
Diabetes
Molecular Docking
Schiff Base
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715624004405
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