Piperine and piperine-loaded albumin nanoparticles ameliorate adjuvant-induced arthritis and reduce IL-17 in rats
Aim: Rheumatoid arthritis (RA) is one of the most common chronic, inflammatory, autoimmune diseases affecting mainly the joints. Piperine (PIP), an alkaloid found in black pepper, has anti-inflammatory properties and its use in drug delivery systems such as nanoparticles might be a treatment for RA....
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| Language: | English |
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Elsevier
2024-12-01
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| Series: | Experimental and Molecular Pathology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S001448002400056X |
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| author | Nasser Gholijani Negar Azarpira Samira-Sadat Abolmaali Nader Tanideh Mohammad-Hadi Ravanrooy Farzane Taki Gholamreza Daryabor |
| author_facet | Nasser Gholijani Negar Azarpira Samira-Sadat Abolmaali Nader Tanideh Mohammad-Hadi Ravanrooy Farzane Taki Gholamreza Daryabor |
| author_sort | Nasser Gholijani |
| collection | DOAJ |
| description | Aim: Rheumatoid arthritis (RA) is one of the most common chronic, inflammatory, autoimmune diseases affecting mainly the joints. Piperine (PIP), an alkaloid found in black pepper, has anti-inflammatory properties and its use in drug delivery systems such as nanoparticles might be a treatment for RA. This study aims to evaluate the possible anti-inflammatory and anti-arthritic effects of PIP and its use in albumin nanoparticles as a possible approach for the treatment of Adjuvant-induced arthritis (AIA) rats. Methods: PIP-loaded Bovine Serum Albumin nanoparticles (PIP-BSA NPs) were prepared using a desolvation method. AIA rats were given intraperitoneal injections of either 40 mg PIP or 131 mg PIP-BSA NPs every two days until day 28 when animals were sacrificed. Clinical score, histopathology, X-ray radiography, and serum levels of pro-inflammatory cytokines such as IL-1β, IL-17, and TNF-α were evaluated. Results: PIP and PIP-BSA NPs significantly reduced clinical scores, and alleviated inflammation within the joints. PIP was superior to PIP-BSA NPs for the alleviation of fibrin deposition and periosteal reactions while bone inflammation and erosion were less severe in the case of PIP-BSA NPs. Besides, both of the treatments suppressed serum levels of IL-17 in AIA rats (p = 0.003 and p = 0.02; respectively). Conclusions: PIP and PIP-BSA NPs effectively alleviate the severity of AIA and suppress inflammation. Due to the superiority of PIP in improving fibrin deposition and periosteal reactions and the efficacy of PIP-BSA NPs in suppressing bone inflammation and erosion, their simultaneous use might be investigated. |
| format | Article |
| id | doaj-art-d41e9ec1a6274ba5aa501800b41d066d |
| institution | OA Journals |
| issn | 1096-0945 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental and Molecular Pathology |
| spelling | doaj-art-d41e9ec1a6274ba5aa501800b41d066d2025-08-20T01:57:55ZengElsevierExperimental and Molecular Pathology1096-09452024-12-0114010493710.1016/j.yexmp.2024.104937Piperine and piperine-loaded albumin nanoparticles ameliorate adjuvant-induced arthritis and reduce IL-17 in ratsNasser Gholijani0Negar Azarpira1Samira-Sadat Abolmaali2Nader Tanideh3Mohammad-Hadi Ravanrooy4Farzane Taki5Gholamreza Daryabor6Autoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, IranTransplant Research Center, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pharmaceutical Nanotechnology and Nanotechnology in Drug Delivery Research Center, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranStem Cells Technology Research Center, Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranFatak Chemie Pars Pharmaceutical Co, Semnan, IranAutoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, IranAutoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Corresponding author at: Autoimmune Diseases Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Aim: Rheumatoid arthritis (RA) is one of the most common chronic, inflammatory, autoimmune diseases affecting mainly the joints. Piperine (PIP), an alkaloid found in black pepper, has anti-inflammatory properties and its use in drug delivery systems such as nanoparticles might be a treatment for RA. This study aims to evaluate the possible anti-inflammatory and anti-arthritic effects of PIP and its use in albumin nanoparticles as a possible approach for the treatment of Adjuvant-induced arthritis (AIA) rats. Methods: PIP-loaded Bovine Serum Albumin nanoparticles (PIP-BSA NPs) were prepared using a desolvation method. AIA rats were given intraperitoneal injections of either 40 mg PIP or 131 mg PIP-BSA NPs every two days until day 28 when animals were sacrificed. Clinical score, histopathology, X-ray radiography, and serum levels of pro-inflammatory cytokines such as IL-1β, IL-17, and TNF-α were evaluated. Results: PIP and PIP-BSA NPs significantly reduced clinical scores, and alleviated inflammation within the joints. PIP was superior to PIP-BSA NPs for the alleviation of fibrin deposition and periosteal reactions while bone inflammation and erosion were less severe in the case of PIP-BSA NPs. Besides, both of the treatments suppressed serum levels of IL-17 in AIA rats (p = 0.003 and p = 0.02; respectively). Conclusions: PIP and PIP-BSA NPs effectively alleviate the severity of AIA and suppress inflammation. Due to the superiority of PIP in improving fibrin deposition and periosteal reactions and the efficacy of PIP-BSA NPs in suppressing bone inflammation and erosion, their simultaneous use might be investigated.http://www.sciencedirect.com/science/article/pii/S001448002400056XAdjuvant-induced arthritis (AIA)InflammationIL-17PiperineAlbumin nanoparticles |
| spellingShingle | Nasser Gholijani Negar Azarpira Samira-Sadat Abolmaali Nader Tanideh Mohammad-Hadi Ravanrooy Farzane Taki Gholamreza Daryabor Piperine and piperine-loaded albumin nanoparticles ameliorate adjuvant-induced arthritis and reduce IL-17 in rats Experimental and Molecular Pathology Adjuvant-induced arthritis (AIA) Inflammation IL-17 Piperine Albumin nanoparticles |
| title | Piperine and piperine-loaded albumin nanoparticles ameliorate adjuvant-induced arthritis and reduce IL-17 in rats |
| title_full | Piperine and piperine-loaded albumin nanoparticles ameliorate adjuvant-induced arthritis and reduce IL-17 in rats |
| title_fullStr | Piperine and piperine-loaded albumin nanoparticles ameliorate adjuvant-induced arthritis and reduce IL-17 in rats |
| title_full_unstemmed | Piperine and piperine-loaded albumin nanoparticles ameliorate adjuvant-induced arthritis and reduce IL-17 in rats |
| title_short | Piperine and piperine-loaded albumin nanoparticles ameliorate adjuvant-induced arthritis and reduce IL-17 in rats |
| title_sort | piperine and piperine loaded albumin nanoparticles ameliorate adjuvant induced arthritis and reduce il 17 in rats |
| topic | Adjuvant-induced arthritis (AIA) Inflammation IL-17 Piperine Albumin nanoparticles |
| url | http://www.sciencedirect.com/science/article/pii/S001448002400056X |
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